Abstract：
:The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their physicochemical properties, flow properties, particle friability and compaction properties, and to compare them to commercially available types of lactose for direct compression (spray-dried, granulated and anhydrous β-lactose). Porous spherical agglomerates of α-lactose monohydrate with radially arranged prism-like primary particles were prepared exhibiting a high specific surface area. All types of lactose analysed had passable or better flow properties, except for anhydrous β-lactose, which had poor flowability. Particle friability was more pronounced in larger granulated lactose particles; however, particle structure was retained in all samples analysed. The mechanical properties of spherical agglomerates of lactose, in terms of compressibility, established with Walker analysis, and compactibility, established with a compactibility profile, were found to be superior to any commercially available types of lactose. Higher compactibility of spherical agglomerates of lactose is ascribed to significantly higher particle surface area due to a unique internal structure with higher susceptibility to fragmentation.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Lamešić D,Planinšek O,Lavrič Z,Ilić Idoi
10.1016/j.ijpharm.2016.11.040subject
Has Abstractpub_date
2017-01-10 00:00:00pages
247-257issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(16)31103-6journal_volume
516pub_type
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