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Double barrier as an effective method for slower delivery rate of ibuprofen.

Abstract：

:Ibuprofen (IBU) was chosen as a model drug to investigate the drug delivery rate. Mesoporous MCM-41 has been charged with ibuprofen (MCM-41_IBU). Calcium alginate was applied to encapsulate free drug and the mesoporous material. The system with double barrier demonstrated a slower release of IBU than free ibuprofen-loaded alginate beads and MCM-41_IBU. The IBU release from alginate matrix can be controlled by adjusting the free IBU/MCM-41_IBU ratio.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Kurczewska J,Lewandowski D,Olejnik A,Schroeder G,Nowak I

doi

10.1016/j.ijpharm.2014.06.037

subject

Has Abstract

pub_date

2014-09-10 00:00:00

pages

248-50

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(14)00466-9

journal_volume

472

pub_type

杂志文章

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