Abstract：
:The development of vaccine delivery systems that will remove or reduce the need for repeated dosing has led to the investigation of sustained release systems. In this context, the duration of antigen release is of great importance as is the requirement for concomitant adjuvant release. In this work, lipid implants consisting of cholesterol (CHOL), soybean lecithin, Dynasan 114 (D114), the model antigen ovalbumin (OVA) and the adjuvant Quil-A (QA) were produced by twin-screw extrusion. The release of antigen and adjuvant was investigated in vitro and we observed complete OVA release over a period of 7 days while QA was released in a linear fashion over a period of up to 12 days. In order to extend OVA release, lipid implants were subjected to post-extrusion curing at 45-55°C. The OVA release could be extended to up to 14 days. Furthermore the influence of the implant composition on the release of the model antigen was investigated. It was shown that the percentage of cholesterol in particular plays an important role in modulating release.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Even MP,Bobbala S,Kooi KL,Hook S,Winter G,Engert Jdoi
10.1016/j.ijpharm.2015.06.052subject
Has Abstractpub_date
2015-09-30 00:00:00pages
102-10issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30016-8journal_volume
493pub_type
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journal_title：International journal of pharmaceutics
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