abstract：:Aim of the study was to reduce the dose and dosing frequency of duloxetine HCl (DXT) by complexation with sulfobutylether-β-cyclodextrin (SBEβCD), an anionic cyclodextrin through permeation enhancement for more effective management of depression. Spray dried inclusion complexes of drug with SBEβCD were prepared and in...

journal_title：International journal of pharmaceutics

authors： Kumar R,Sinha VR,Dahiya L,Sarwal A

更新日期：2021-02-01 00:00:00

abstract：:Oral delivery of macromolecular drugs is the most patient-preferred route of administration because it is painless and convenient. Over the past 30 years, significant attention has been paid to oral protein delivery in adults. Unfortunately, there is an outstanding need for similar efforts in infants, a patient popula...

journal_title：International journal of pharmaceutics

authors： Gleeson JP,Fein KC,Chaudhary N,Doerfler R,Newby AN,Whitehead KA

更新日期：2021-01-25 00:00:00

abstract：:Tramadol (TRA) is a weak opioid analgesic, prescribed to relieve mild to moderately severe pain. However, side effects of TRA overdoses, including vomiting, depression, tachycardia, convulsions, morbidity and mortality are often reported. In this study, an electrochemical sensor based on molecularly imprinted conducti...

journal_title：International journal of pharmaceutics

authors： Diouf A,Aghoutane Y,Burhan H,Sen F,Bouchikhi B,El Bari N

更新日期：2021-01-25 00:00:00

abstract：:Osteoporosis therapy consists of inhibiting the osteoclasts' activity and promoting osteoblasts' osteogenesis. Salmon calcitonin (sCT) could realize both requirements, however, it is limited by the low bioavailability caused by fibrillation. Supramolecular assembly of sCT and biocompatible agents into nanoassemblies p...

journal_title：International journal of pharmaceutics

authors： Yu P,Xu Z,Zhai X,Liu Y,Sun H,Xu X,Xie J,Li J

更新日期：2021-01-25 00:00:00

abstract：:The breast cancer resistance protein (BCRP) is an efflux transporter expressed at the apical surface of human brain endothelial cells of the blood-brain barrier (BBB). It was proposed as one of the transporters responsible for the development of drug resistance to several central nervous system (CNS) drugs, including ...

journal_title：International journal of pharmaceutics

authors： Gonçalves J,Silva S,Gouveia F,Bicker J,Falcão A,Alves G,Fortuna A

更新日期：2021-01-25 00:00:00

abstract：:Current treatment for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) involves transvaginal implantation of surgical mesh, conventionally made of polypropylene (PP). However, it has recently become apparent that the mechanical properties of PP are unsuitable, resulting in serious complications such a...

journal_title：International journal of pharmaceutics

authors： Farmer ZL,Utomo E,Domínguez-Robles J,Mancinelli C,Mathew E,Larrañeta E,Lamprou DA

更新日期：2021-01-25 00:00:00

abstract：:Felodipine is a calcium channel blocker, which shows low oral bioavailability (<15%) owing to poor water solubility and high first pass metabolism. The aim of the present investigation was to study the surface science (dynamic surface tension) and characteristics of microemulsion (Capmul MCM, Tween 20 and polyethylene...

journal_title：International journal of pharmaceutics

authors： Koli AR,Ranch KM,Patel HP,Parikh RK,Shah DO,Maulvi FA

更新日期：2021-01-23 00:00:00

abstract：:Minimizing variability in the feeding process is important for continuous manufacturing since materials are fed individually and can impact the final product. This study demonstrates the importance of measuring powder properties and highlights the need to characterize the feeding performance both offline with multiple...

journal_title：International journal of pharmaceutics

authors： Allenspach C,Timmins P,Lumay G,Holman J,Minko T

更新日期：2021-01-21 00:00:00

abstract：:Chronic non-healing wounds tender a great challenge to patients, physicians, and wound care professionals. In view of the increasing prevalence of chronic wounds due to ischemia, diabetic foot, venous, and pressure ulcers, their appropriate management requires significant attention. Along with the basic techniques of ...

journal_title：International journal of pharmaceutics

authors： Maaz Arif M,Maqsood Khan S,Gull N,Tabish TA,Zia S,Ullah Khan R,Muhammad Awais S,Arif Butt M

更新日期：2021-01-21 00:00:00

abstract：:Glioblastoma (GBM) is a difficult-to-treat cancer, likely attributed to the blood brain barrier and drug resistance. Nose-to-brain drug delivery is a direct and non-invasive pathway for brain targeting with low systemic toxicity. Disulfiram (DSF) has shown its effectiveness against GBM, especially with copper ion (Cu)...

journal_title：International journal of pharmaceutics

authors： Qu Y,Li A,Ma L,Iqbal S,Sun X,Ma W,Li C,Zheng D,Xu Z,Zhao Z,Ma D

更新日期：2021-01-21 00:00:00

abstract：:Inadequate flowability of powders in industries during handling can cause many problems. For example, lack of flow from hoppers, poor tablet weight consistency, and low production rate in tableting. Many factors are known to commonly affect flow properties of powders, such as temperature, humidity and conditioning dur...

journal_title：International journal of pharmaceutics

authors： Salehi H,Karde V,Hajmohammadi H,Dissanayake S,Larsson SH,Y Y Heng J,Bradley M

更新日期：2021-01-20 00:00:00

abstract：:Surface functionalisation of polymeric electrospun scaffolds with therapeutic biomolecules is often explored in regenerative medicine and tissue engineering. However, the bioconjugation method must be carefully selected to prevent partial or full loss of activity of the biomolecule following chemical manipulation. Per...

journal_title：International journal of pharmaceutics

authors： Dziemidowicz K,Brocchini S,Williams GR

更新日期：2021-01-20 00:00:00

abstract：:The ability to predict mechanical properties of compacted powder blends of Active Pharmaceutical Ingredients (API) and excipients solely from component properties can reduce the amount of 'trial-and-error' involved in formulation design. Machine Learning (ML) can reduce model development time and effort with the imper...

journal_title：International journal of pharmaceutics

authors： Thomas S,Palahnuk H,Amini H,Akseli I

更新日期：2021-01-05 00:00:00

abstract：:The concept of skin-specific drug delivery with a spatio-temporal control has just recently received concerns in dermatology. Inspired by the progress in smart materials and their perspective application in medicine science, development of stimuli responsive drug delivery systems with skin-specificity has become possi...

journal_title：International journal of pharmaceutics

authors： Chen Y,Chen N,Feng X

更新日期：2021-01-05 00:00:00

abstract：:Inhalation drug delivery has seen a swift rise in the use of dry powder inhalers (DPIs) to treat chronic respiratory conditions. However, universal adoption of DPIs has been restrained due to their low efficiencies and significant drug losses in the mouth-throat region. Aerosol efficiency of DPIs is closely related to...

journal_title：International journal of pharmaceutics

authors： Dos Reis LG,Chaugule V,Fletcher DF,Young PM,Traini D,Soria J

更新日期：2021-01-05 00:00:00

abstract：:The concepts of mucoadhesion and mucoadhesive polymers were introduced in the 20th century, leading to several advantages. These included enhanced drug absorption and extended residence at specific site of action. Polymeric excipients underwent chemical modification with sulfhydryl groups on the polymeric backbone so ...

journal_title：International journal of pharmaceutics

authors： Sanchez Armengol E,Laffleur F

更新日期：2021-01-05 00:00:00

abstract：:The infection of bone and bone marrow is called osteomyelitis. Treatment is difficult since antibiotics can not reach with enough concentration to the infected area. For the first time in this study, we have developed gentamicin-loaded magnetic gelatin nanoparticles (GMGNPs) for nanocarrier-mediated and magnetically t...

journal_title：International journal of pharmaceutics

authors： Ak G,Bozkaya ÜF,Yılmaz H,Sarı Turgut Ö,Bilgin İ,Tomruk C,Uyanıkgil Y,Hamarat Şanlıer Ş

更新日期：2021-01-05 00:00:00

abstract：:The clinical efficacy of the PEGylated doxorubicin liposomes (PLD) is limited by low tumor accumulation and limited intra-tumoral disposition. Decoration with the cell penetration enhancers (CPEs) can increase the PLD permeability via the biological barriers, however at the expense of enhanced distribution to the non-...

journal_title：International journal of pharmaceutics

authors： Popilski H,Feinshtein V,Kleiman S,Mattarei A,Garofalo M,Salmaso S,Stepensky D

更新日期：2021-01-05 00:00:00

abstract：:Low-frequency Raman (LFR) spectroscopy probes vibrational modes related to long-range order (i.e., crystallinity) that can provide unique information on the solid-state/structural characteristics among other properties. Furthermore, the recent advancements in instrumentation (most notably, narrow wavelength band filte...

journal_title：International journal of pharmaceutics

authors： Bērziņš K,Fraser-Miller SJ,Gordon KC

更新日期：2021-01-05 00:00:00

abstract：:Metformin has several problems such as low bioavailability, short half-life, and narrow absorption window, sustained and site-specific drug delivery system is required. Floating drug delivery systems are very useful to achieve these purposes. However, conventional floating systems have several limitations; lag time, a...

journal_title：International journal of pharmaceutics

authors： Wook Huh H,Na YG,Kang H,Kim M,Han M,Mai Anh Pham T,Lee H,Baek JS,Lee HK,Cho CW

更新日期：2021-01-05 00:00:00

abstract：:An extrusion based 3D printer was used to prepare the semi-solid tablets with different drug loading dosages (75, 100, 125 mg) under ambient temperature. The active pharmaceutical ingredient, theophylline, was uploaded within the hydrogels prepared of hydroxypropyl methylcellulose (HPMC) K4M or E4M. The HPMC concentra...

journal_title：International journal of pharmaceutics

authors： Cheng Y,Qin H,Acevedo NC,Jiang X,Shi X

更新日期：2020-12-15 00:00:00

abstract：:Spray drying can be utilized to produce highly dispersible powder aerosol formulations. However, these formulations are known to be hygroscopic, leading to potential solid-state stability and aerosol performance issues. This study aims to investigate if control of the spray drying particle formation conditions could b...

journal_title：International journal of pharmaceutics

authors： Hassan A,Farkas D,Longest W,Hindle M

更新日期：2020-12-15 00:00:00

abstract：:We studied optimized conditions for preparing ternary hot extrudates (HEs) of glibenclamide (GLB)/polyvinylpyrrolidone (PVP)/sodium dodecyl sulfate to generate stable nanocrystal suspensions following aqueous dispersion. Raman and solid-state NMR measurements of ternary HEs prepared by altering HE conditions revealed ...

journal_title：International journal of pharmaceutics

authors： Omagari K,Ueda K,Zhijing Z,Higashi K,Inoue M,Fukami T,Moribe K

更新日期：2020-12-15 00:00:00

abstract：:Intake of probiotics is associated with many health benefits, which has generated an interest in formulating viable probiotic supplements. The present study had two aims. The first aim was to achieve gastrointestinal protection and delayed release of viable probiotics by pelletizing and coating freeze-dried probiotic ...

journal_title：International journal of pharmaceutics

authors： Jacobsen NMY,Caglayan I,Caglayan A,Bar-Shalom D,Müllertz A

更新日期：2020-12-15 00:00:00

abstract：:In cutaneous drug delivery, it is widely accepted that the choice of excipients affects the delivery of a drug molecule to the skin. MALDI mass spectrometry imaging (MALDI-MSI) is an imaging technique which enables the simultaneous detection of multiple compounds. MALDI-MSI was applied to study the penetration of tofa...

journal_title：International journal of pharmaceutics

authors： Handler AM,Fallah M,Just Pedersen A,Pommergaard Pedersen G,Troensegaard Nielsen K,Janfelt C

更新日期：2020-11-30 00:00:00

abstract：:Diabetic ulcers are prone to bacterial contamination and can severely affect patient's quality of life. This study is first report to explore copper-grafted graphene oxide-crosslinked zein scaffolds (Cu-GZS) for promoting cutaneous excision wounds healing as a promising therapeutic modality in diabetic male-rats. Cu-G...

journal_title：International journal of pharmaceutics

authors： El-Lakany SA,Kamoun EA,Abd-Elhamid AI,Aly RG,Samy WM,Elgindy NA

更新日期：2020-11-30 00:00:00

abstract：:Freeze-drying is the preferred method to manufacture proteins in their solid state thus the understanding of the relationship between cycle parameters and cake properties remains of great interest. The present study aims to investigate the influence of the freezing conditions in the material properties at different la...

journal_title：International journal of pharmaceutics

authors： Badal Tejedor M,Fransson J,Millqvist-Fureby A

更新日期：2020-11-30 00:00:00

abstract：:This preclinical study compared plasma concentrations and distribution of ruxolitinib in the skin of Göttingen minipigs following twice a day oral (40 mg/kg) versus topical administration (1.5% w/w cream applied to 10% of body surface area). Following oral administration, the plasma area-under-the-curve was approximat...

journal_title：International journal of pharmaceutics

authors： Persaud I,Diamond S,Pan R,Burke K,Harris J,Conlin M,Yeleswaram S

更新日期：2020-11-30 00:00:00

abstract：:The current investigation was carried out to identify appropriate parameters for measuring the in vitro release of tobramycin (TOB) ophthalmic ointments and to evaluate the feasibility of in vitro release testing methods to assess the product performance. Drug release was assessed using USP dissolution apparatus IV an...

journal_title：International journal of pharmaceutics

authors： Patere S,Newman B,Wang Y,Choi S,Mekjaruskul C,Jay M,Lu X

更新日期：2020-11-30 00:00:00

abstract：:Viscous liquid degradable polymers have advantages as drug depots for sustained protein delivery. We have created a new aliphatic polycarbonate for this purpose, poly(trimethylene carbonate-co-5-hydroxy trimethylene carbonate), which upon degradation retains a near neutral micro-environmental pH. As such, this copolym...

journal_title：International journal of pharmaceutics

authors： Mohajeri S,Burke-Kleinman J,Maurice DH,Amsden BG

更新日期：2020-11-30 00:00:00

abstract：:In this paper, we present a kinetic investigation of the polymorphic transformation γ → α of sorbitol under milling in the objective to identify the microscopic mechanisms that govern this type of solid-state transformation. The milling was performed with a high energy planetary mill and the milled material was analys...

journal_title：International journal of pharmaceutics

authors： Dupont A,Guerain M,Danède F,Paccou L,Guinet Y,Hédoux A,Willart JF

更新日期：2020-11-30 00:00:00

abstract：:The human body harbours a large variety of microbial communities. It is already well-known that these communities play an important role in human health. Therefore, microbial imbalances can be responsible for several health disorders by different mechanisms. In recent years, probiotic bacteria have been increasingly a...

journal_title：International journal of pharmaceutics

authors： Byl E,Jokicevic K,Kiekens S,Lebeer S,Kiekens F

更新日期：2020-10-15 00:00:00

abstract：:The effect of the GlycoPEGylation process used for prolonging the half-life of recombinant factor IX (rFIX) has no impact on the primary and higher order structure of activated factor IX. Characterisation work performed on recombinant factor IX and on the GlycoPEGylated form of rFIX (N9-GP), confirm that the primary s...

journal_title：International journal of pharmaceutics

authors： Nielsen FS,Schmidt AS,Kristensen AK,Nielsen AD,Kristensen BK,Palm L

更新日期：2020-10-15 00:00:00

abstract：:The short half-life and bitter taste of carbinoxamine maleate2 (CAM) lead to poor compliance by pediatric patients who are being treated for allergic rhinitis. To address these issues, carbinoxamine-resin complexes3 (CRCs) were prepared by ion exchange and then coated with Kollicoat SR 30D. The resultant microencapsul...

journal_title：International journal of pharmaceutics

authors： Deng Y,Wang T,Li J,Sun W,He H,Gou J,Wang Y,Yin T,Zhang Y,Tang X

更新日期：2020-10-15 00:00:00

abstract：:Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregna...

journal_title：International journal of pharmaceutics

authors： Cam ME,Hazar-Yavuz AN,Cesur S,Ozkan O,Alenezi H,Turkoglu Sasmazel H,Sayip Eroglu M,Brako F,Ahmed J,Kabasakal L,Ren G,Gunduz O,Edirisinghe M

更新日期：2020-10-15 00:00:00

abstract：:In recent years, core-shell nanofibrous drug delivery systems have received increasing attention due to their ability to incorporate two or more active pharmaceutical ingredients (APIs) individually into the desired layer (either core or sheath) and thereby finely tune the release profiles of even incompatible drugs i...

journal_title：International journal of pharmaceutics

authors： Kazsoki A,Farkas A,Balogh-Weiser D,Mancuso E,Sharma PK,Lamprou DA,Zelkó R

更新日期：2020-09-25 00:00:00

abstract：:Rifampicin is a first-line, highly effective drug currently used orally as a part of a lengthy multi-drug regimen against tuberculosis (TB). Despite the potential of inhaled therapy as an effective approach for TB treatment, an inhalable formulation of rifampicin has not yet been developed for clinical use. In order t...

journal_title：International journal of pharmaceutics

authors： Khadka P,Hill PC,Zhang B,Katare R,Dummer J,Das SC

更新日期：2020-09-25 00:00:00

abstract：:Symprove, a multi-strain probiotic, has been shown to exert a mild anti-inflammatory effect in patients with ulcerative colitis (UC). We examined stool samples from 3 patients with UC in order to create microbiotas in an in-vitro gut model. The effects of Symprove on bacterial diversity and metabolic activity in the m...

journal_title：International journal of pharmaceutics

authors： Ghyselinck J,Verstrepen L,Moens F,Van den Abbeele P,Said J,Smith B,Bjarnason I,Basit AW,Gaisford S

更新日期：2020-09-25 00:00:00

abstract：:Furosemide (FSM) is a biopharmaceutical classification system (BCS) class IV drug, being a potent loop diuretic used in the treatment of congestive heart failure and edema. Due to its low solubility and permeability, FSM is known for exhibiting poor oral bioavailability. In order to overcome or even minimize these und...

journal_title：International journal of pharmaceutics

authors： Diniz LF,Carvalho PS Jr,Pena SAC,Gonçalves JE,Souza MAC,de Souza Filho JD,Bomfim Filho LFO,Franco CHJ,Diniz R,Fernandes C

更新日期：2020-09-25 00:00:00

abstract：:Along with the malignant proliferation of tumor requiring nutrients, the expression of L-type amino acid transporter 1(LAT1) and amino acid transporter B0,+ (ATB0,+) in cancer cells is up-regulated that can be used as new targets for active targeting of tumor. However, since normal cells also express amino acid transp...

journal_title：International journal of pharmaceutics

authors： Wang Z,Lin X,Chi D,Xu Z,Lin G,Liu H,Sun J,He Z,Wang Y

更新日期：2020-09-25 00:00:00