当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: solubilization, in vitro release and biological evaluation.

Amino acid based amphiphilic copolymer micelles as carriers of non-steroidal anti-inflammatory drugs: solubilization, in vitro release and biological evaluation.

Abstract：

:Three novel amino acid based anionic amphiphilic copolymers poly(sodium N-acryloyl-l-valinate-co-alkylacrylamide) (where, alkyl=octyl and dodecyl) with either 9 or 16 mol% hydrophobic substitution were synthesized. These hydrophobically modified polyelectrolytes (HMPs), above a critical concentration, self-assemble in aqueous solution through inter-chain hydrophobic aggregation, forming micelle-like aggregates having hydrodynamic diameter in the range of 50-200 nm. The HMPs were found to undergo conformational changes with the change in solution pH, electrolyte and additive concentration, and temperature. The polymeric micelles were observed to be stable under biological conditions (pH 7.4, [NaCl]=150 mM and temperature (37°C)). The solubilization capacity of the polymeric micelles for six important non-steroidal anti-inflammatory drugs of different hydrophobicity was evaluated. Depending upon the hydrophobicity the solubilities of the drugs were observed to increase ca. 2-10 times in the presence of 1.0 g/L copolymers. The in vitro release kinetics of the loaded drug was studied under physiological pH. To explore their potential application in pharmaceutical industries hemocompatibility and cytotoxicity studies were carried out using hemolytic and MTT assay, respectively. The anionic HMPs were found to be not directly toxic to mammalian cells.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Dutta P,Dey J,Perumal V,Mandal M

doi

10.1016/j.ijpharm.2011.01.041

subject

Has Abstract

pub_date

2011-04-04 00:00:00

pages

207-16

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(11)00072-X

journal_volume

407

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Preparation and characterization of two-phase melt systems of lidocaine.

    abstract：:The melting point of lidocaine was significantly lowered when mixed with thymol and/or aqueous ethanol. Mixtures of lidocaine and thymol at ratios within the range of 30:70-70:30 (w:w) became homogeneous oils at 25 degrees C. In a pH 9.2 carbonate buffer containing 25% ethanol, lidocaine (5%, w:w) also liquefied at 25...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00689-5

    authors： Kang L,Jun HW,Mani N

    更新日期：2001-07-03 00:00:00

  • Characterization and monitoring of pseudo-polymorphs in manufacturing process by NIR.

    abstract：:Moisture-sensitive pseudo-polymorphs with different stabilities were characterized, and their polymorphisms were monitored in the process of tableting and film coating by near-infrared (NIR) spectroscopy. In this study, we proved that we could successfully maintain the crystal form ratio in the tablet by controlling t...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.10.010

    authors： Kamada K,Yoshimura S,Murata M,Murata H,Nagai H,Ushio H,Terada K

    更新日期：2009-02-23 00:00:00

  • Enhanced solubility and modified release of poorly water-soluble drugs via self-assembled gelatin-oleic acid nanoparticles.

    abstract：:Recently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.025

    authors： Tran PH,Tran TT,Lee BJ

    更新日期：2013-10-15 00:00:00

  • Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel.

    abstract：:The main objective of the study was to evaluate if the liquid crystalline cubic phase gel of glyceryl monooleate (GMO) protects insulin from agitation induced aggregation. The aggregation of Humulin(R), Regular Iletin I(R) and Regular Iletin II(R), in cubic phase GMO gels at 30 U/g of gel was compared with that in PBS...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00288-4

    authors： Sadhale Y,Shah JC

    更新日期：1999-11-25 00:00:00

  • Mucoadhesivity and release properties of quaternary ammonium-chitosan conjugates and their nanoparticulate supramolecular aggregates: an NMR investigation.

    abstract：:Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium-chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.018

    authors： Uccello-Barretta G,Balzano F,Aiello F,Senatore A,Fabiano A,Zambito Y

    更新日期：2014-01-30 00:00:00

  • A century of dissolution research: from Noyes and Whitney to the biopharmaceutics classification system.

    abstract：:Dissolution research started to develop about 100 years ago as a field of physical chemistry and since then important progress has been made. However, explicit interest in drug related dissolution has grown only since the realisation that dissolution is an important factor of drug bioavailability in the 1950s. This re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.07.011

    authors： Dokoumetzidis A,Macheras P

    更新日期：2006-09-14 00:00:00

  • Search for technological reasons to develop a capsule or a tablet formulation with respect to wettability and dissolution.

    abstract：:Proquazone, a poorly wettable compound, was used as a model drug in the search for reasons to develop a capsule or tablet formulation. The capsules were filled with proquazone as active ingredient, with lactose monohydrate (200 mesh) as filler and with magnesium stearate as lubricant. The tablet was made out of a gran...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.09.006

    authors： von Orelli J,Leuenberger H

    更新日期：2004-12-09 00:00:00

  • An insight into powder entrainment and drug delivery mechanisms from a modified Rotahaler®.

    abstract：:This study aims to improve understanding of the powder fluidisation and aerosolisation processes unique to a split capsule dry powder inhaler. It uses a combination of dynamic real-time methods and a suite of powder material physicochemical characterisation methods. The study focused on examining the effect of differe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.08.038

    authors： Sim S,Margo K,Parks J,Howell R,Hebbink GA,Orlando L,Larson I,Leslie P,Ho L,Morton DA

    更新日期：2014-12-30 00:00:00

  • Formation of the dispersed particles composed of retinol and phosphatidylchiline.

    abstract：:The purpose of this study was to investigate the dispersal mechanism of retinol (Vitamin A, VA) into phospholipid. VA was dispersed with soybean phosphatidylcholine (PC) using sonication and the dispersal mechanism was evaluated by characterizing the dispersed particles using dynamic light scattering, fluorescence spe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00677-4

    authors： Asai Y

    更新日期：2003-03-06 00:00:00

  • GSH responsive nanomedicines self-assembled from small molecule prodrug alleviate the toxicity of cardiac glycosides as potent cancer drugs.

    abstract：:Cardiac glycosides (CGs) have been used to treat cancer for hundreds of years. However, the narrow therapeutic window and system toxicity have hindered their wide clinical applications. Herein, the small molecule prodrug strategy and nanotechnology were integrated into one drug delivery system with enhanced therapeuti...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118980

    authors： Zhang H,Zhu Y,Sun C,Xie Y,Adu-Frimpong M,Deng W,Yu J,Xu X,Han Z,Qi G

    更新日期：2020-02-15 00:00:00

  • Poly(ε-caprolactone)/triclosan loaded polylactic acid nanoparticles composite: A long-term antibacterial bionanocomposite with sustained release.

    abstract：:In this study, the antibacterial bionanocomposites of poly(ε-caprolactone) (PCL) with different concentrations of triclosan (TC) loaded polylactic acid (PLA) nanoparticles (30wt% triclosan) (LATC30) were fabricated via a melt mixing process in order to lower the burst release of PCL and to extend the antibacterial act...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.009

    authors： Kaffashi B,Davoodi S,Oliaei E

    更新日期：2016-07-11 00:00:00

  • Water solubilization capacity of pharmaceutical microemulsions based on Peceol®, lecithin and ethanol.

    abstract：:Biocompatible microemulsions composed of Peceol(®), lecithin, ethanol and water developed for encapsulation of hydrophilic drugs were investigated. The binary mixture Peceol(®)/ethanol was studied first. It was shown that the addition of ethanol to pure Peceol(®) has a significant fluidifying and disordering effect on...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.07.018

    authors： Mouri A,Diat O,Lerner DA,El Ghzaoui A,Ajovalasit A,Dorandeu C,Maurel JC,Devoisselle JM,Legrand P

    更新日期：2014-11-20 00:00:00

  • Green fabricated reduced graphene oxide: evaluation of its application as nano-carrier for pH-sensitive drug delivery.

    abstract：:A green and mild approach for the preparation of reduced graphene oxide (rGO) was proposed by using riboflavin-5'-phosphate sodium salt dihydrate as a reducing reagent and stabilizer without any other reagent. The fabricated nano-rGO was systematically evaluated for its application as nano-carrier for pH-sensitive dru...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.081

    authors： Ma N,Zhang B,Liu J,Zhang P,Li Z,Luan Y

    更新日期：2015-12-30 00:00:00

  • Preparation, characterization and drug release behavior of polyion complex micelles.

    abstract：:Double-hydrophilic block copolymer composed of poly(N-vinylpyrrolidone) (PVP) and poly(styrene-alter-maleic anhydride) (PSMA) has been synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. Poly(N-vinylpyrrolidone)-block-poly(styrene-alter-maleic anhydride) (PVP-b-PSMA) thus formed was ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.03.019

    authors： Luo Y,Wang A,Yuan J,Gao Q

    更新日期：2009-06-05 00:00:00

  • Hydrodynamics-induced variability in the USP apparatus II dissolution test.

    abstract：:The USP tablet dissolution test is an analytical tool used for the verification of drug release processes and formulation selection within the pharmaceutical industry. Given the strong impact of this test, it is surprising that operating conditions and testing devices have been selected empirically. In fact, the flow ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.08.003

    authors： Baxter JL,Kukura J,Muzzio FJ

    更新日期：2005-03-23 00:00:00

  • Transdermal delivery of flurbiprofen from surfactant-based vesicles: particle characterization and the effect of water on in vitro transport.

    abstract：:Flurbiprofen loaded rigid and elastic vesicles comprising the bilayer-forming surfactant sucrose-ester laurate were prepared by the film rehydration and extrusion method. The charge-inducing agent sodium dodecyl sulfate, and the micelle-forming surfactants, sorbitan monolaurate, polyethylene glycol monolaurate, and po...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.051

    authors： Uchino T,Matsumoto Y,Murata A,Oka T,Miyazaki Y,Kagawa Y

    更新日期：2014-04-10 00:00:00

  • Surface decorated nanoparticles as surrogate carriers for improved transport and absorption of epirubicin across the gastrointestinal tract: Pharmacokinetic and pharmacodynamic investigations.

    abstract：:Epirubicin (EPI) is a P-gp substrate antracycline analogue which elicits poor oral bioavailability. In the present work, EPI loaded poly-lactide-co-glycolic acid nanoparticles (PLGA-NPs) were prepared by double emulsion approach and superficially decorated with polyethylene glycol (EPI-PNPs) and mannosamine (EPI-MNPs)...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.01.054

    authors： Tariq M,Alam MA,Singh AT,Panda AK,Talegaonkar S

    更新日期：2016-03-30 00:00:00

  • Fabrication of inhalable spore like pharmaceutical particles for deep lung deposition.

    abstract：:An innovative strategy of fabricating uniform spore like drug particles to improve pulmonary drug delivery efficiency was disclosed in the present study. Spore like particles were prepared through combination of high gravity controlled precipitation and spray drying process with insulin as model drug first, showing ro...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.044

    authors： Shen ZG,Chen WH,Jugade N,Gao LY,Glover W,Shen JY,Yun J,Chen JF

    更新日期：2012-07-01 00:00:00

  • Effect of the surface free energy of materials on the lamination tendency of bilayer tablets.

    abstract：:Dosage forms with fixed dose combinations of drugs is a frequent and advantageous mode of administration, but their production involves a number of technological problems. Numerous interactions in a homogeneous vehicle may be avoided through the use of layered tablets. The mechanical properties of these dosage forms d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.061

    authors： Papós K,Kása P Jr,Ilič I,Blatnik-Urek S,Regdon G Jr,Srčič S,Pintye-Hódi K,Sovány T

    更新日期：2015-12-30 00:00:00

  • Partially hydrolyzed polyvinyl alcohol for fusion-based pharmaceutical formulation processes: Evaluation of suitable plasticizers.

    abstract：:The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes. Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anh...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119121

    authors： Katopodis K,Kapourani A,Vardaka E,Karagianni A,Chorianopoulou C,Kontogiannopoulos KN,Bikiaris DN,Kachrimanis K,Barmpalexis P

    更新日期：2020-03-30 00:00:00

  • Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas.

    abstract：:Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective again...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.023

    authors： Gaubert A,Kauss T,Marchivie M,Ba BB,Lembege M,Fawaz F,Boiron JM,Lafarge X,Lindegardh N,Fabre JL,White NJ,Olliaro PL,Millet P,Grislain L,Gaudin K

    更新日期：2014-07-01 00:00:00

  • Dynamic behavior of a spring-powered micronozzle needle-free injector.

    abstract：:Conventional injection is still the leading method to deliver macromolecular therapeutics. Needle injection is considered a low compliance administration strategy, principally due to pain and needle phobia. This has fostered the research on the development of alternative strategies to circumvent the skin barrier. Amon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.067

    authors： Schoubben A,Cavicchi A,Barberini L,Faraon A,Berti M,Ricci M,Blasi P,Postrioti L

    更新日期：2015-08-01 00:00:00

  • Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets.

    abstract：:Metoprolol succinate extended release tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. Despite the flexibility that control...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.09.004

    authors： Zhao N,Zidan A,Tawakkul M,Sayeed VA,Khan M

    更新日期：2010-11-30 00:00:00

  • Effect of binders on the release rates of direct molded verapamil tablets using twin-screw extruder in melt granulation.

    abstract：:Conventional manufacturing of pharmaceutical tablets often involves single processes such as blending, granulation, milling and direct compression. A process that minimizes and incorporates all these in a single continuous step is desirable. The concept of omitting milling step followed by direct-molding of tablets ut...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.12.053

    authors： Tan DC,Chin WW,Tan EH,Hong S,Gu W,Gokhale R

    更新日期：2014-03-10 00:00:00

  • Photodynamic ultradeformable liposomes: Design and characterization.

    abstract：:Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.11.015

    authors： Montanari J,Perez AP,Di Salvo F,Diz V,Barnadas R,Dicelio L,Doctorovich F,Morilla MJ,Romero EL

    更新日期：2007-02-07 00:00:00

  • The stimulated acoustic relaxation emission of maize starch tablets.

    abstract：:Stimulated acoustic relaxation emissions from maize starch tablets after compression were detected and recorded in the audible region. Stimulation was found to enhance the detected acoustic emission and to maintain recordable acoustic emission level longer. Based on the fact, that the stimulation by a halogen lamp and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00648-2

    authors： Mellin V,Salonen J,Laine E

    更新日期：2001-06-04 00:00:00

  • Release behavior of salicylic acid in supramolecular hydrogels formed by l-phenylalanine derivatives as hydrogelator.

    abstract：:Supramolecular hydrogels were prepared from l-phenylalanine derivatives as novel hydrogelators. Salicylic acid (SA), acting as a model drug, was entrapped in the supramolecular hydrogels. The release behavior of SA molecules in the supramolecular hydrogels was investigated by using UV-vis spectroscopy. The influence o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.01.054

    authors： Cao S,Fu X,Wang N,Wang H,Yang Y

    更新日期：2008-06-05 00:00:00

  • Development of Ussing model coupled with artificial membrane for predicting intestinal absorption mechanisms of drugs.

    abstract：:The absorption mechanisms of drugs play an important role on development and various application of drugs. However, the present methods of absorption mechanisms are not perfect enough. Hence, exploring a novel method to accurately predict the absorption mechanisms is necessary. In this study, we developed an Ussing mo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119170

    authors： Huang S,Huang Y,Yin X,Wang D,Xiang W,Wang M,Xia Z

    更新日期：2020-04-15 00:00:00

  • Paclitaxel isomerisation in polymeric micelles based on hydrophobized hyaluronic acid.

    abstract：:Physical and chemical structure of paclitaxel (PTX) was studied after its incorporation into polymeric micelles made of hyaluronic acid (HA) (Mw=15 kDa) grafted with C6 or C18:1 acyl chains. PTX was physically incorporated into the micellar core by solvent evaporation technique. Maximum loading capacity for HAC6 and H...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.03.024

    authors： Smejkalová D,Nešporová K,Hermannová M,Huerta-Angeles G,Cožíková D,Vištejnová L,Safránková B,Novotný J,Kučerík J,Velebný V

    更新日期：2014-05-15 00:00:00

  • A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.

    abstract：:Liver dysfunction is associated with a variety of liver diseases, including viral or alcoholic hepatitis, fibrosis, cirrhosis, and portal hypertension. A targeted drug delivery system would be very useful in the treatment of these diseases. We herein describe the development of a system comprised of a new peptide-lipi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.068

    authors： Akhter A,Hayashi Y,Sakurai Y,Ohga N,Hida K,Harashima H

    更新日期：2013-11-01 00:00:00