Effect of divalent anions on photodegradation kinetics and pathways of riboflavin in aqueous solution.

Abstract:

:The present investigation is based on a study of the effect of buffer and non-buffer divalent anions (phosphate, sulphate, tartrate, succinate, malonate) on the kinetics, product distribution and photodegradation pathways of riboflavin (RF) at pH 6.0-8.0. RF solutions (5x10(-5)M) were photodegraded in the presence of divalent anions (0.2-1.0M) using a visible light source and the photoproducts, cyclodehydroriboflavin (CDRF), formylmethylflavin (FMF), lumichrome (LC) and lumiflavin (LF) were assayed by a specific multicomponent spectrophotometric method. RF degradation in the presence of divalent anions follows parallel first-order kinetics to give CDRF and LC as the final products through photoaddition and photoreduction reactions, respectively. The divalent anion-catalysed CDRF formation is affected in the order: phosphate>sulphate>tartrate>succinate>malonate, showing maximum activity of the anions around pH 7. The divalent anions cause deviation of the photoreduction pathway in favour of the photoaddition pathway to form CDRF. The first- and second-order rate constants for the reactions involved in the photodegradation of RF have been determined and the rate-pH profiles and pathway relationships discussed. The catalytic activity of the divalent anions appears to be a function of the relative strength and chemical reactivity of the RF-divalent anion complex acting as a mediator in the photoaddition reaction.

journal_name

Int J Pharm

authors

Ahmad I,Ahmed S,Sheraz MA,Vaid FH,Ansari IA

doi

10.1016/j.ijpharm.2010.01.042

subject

Has Abstract

pub_date

2010-05-10 00:00:00

pages

174-82

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(10)00095-5

journal_volume

390

pub_type

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