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Preparation and characterization of n-dodecyl-ferulate-loaded solid lipid nanoparticles (SLN).

Abstract：

:Solid lipid nanoparticles (SLN) containing a novel potential sunscreen n-dodecyl-ferulate (ester of ferulic acid) were developed. The preparation and stability parameters of n-dodecyl-ferulate-loaded SLN have been investigated concerning particle size, surface electrical charge (zeta potential) and matrix crystallinity. The chemical stability of n-dodecyl-ferulate at high temperatures was also assessed by thermal gravimetry analysis. For the selection of the appropriated lipid matrix, chemically different lipids were melted with 4% (m/m) of active and lipid nanoparticles were prepared by the so-called high pressure homogenization technique. n-Dodecyl-ferulate-loaded SLN prepared with cetyl palmitate showed the lowest mean particle size and polydispersity index, as well as the highest physical stability during storage time of 21 days at 4, 20 and 40 degrees C. These colloidal dispersions containing the sunscreen also exhibited the common melting behaviour of aqueous SLN dispersions.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Souto EB,Anselmi C,Centini M,Müller RH

doi

10.1016/j.ijpharm.2005.02.005

keywords:

subject

Has Abstract

pub_date

2005-05-13 00:00:00

pages

261-8

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(05)00112-2

journal_volume

295

pub_type

杂志文章

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