Abstract:
:We report here the synthesis, in vitro and in vivo investigation of magnetic resonance imaging (MRI) active nanoparticles, which target folate receptor overexpressing tumor cells. Self-assembled nanoparticles with a hydrodynamic size of 50-200 nm were prepared from poly-γ-glutamic acid and chitosan biopolymers with Gd-ions. The nanoparticles are biocompatible, non-toxic and stable for several months in aqueous media. In vitro assays using confocal microscopy, flow cytometry and MR imaging on HeLa human cervix carcinoma tumor cells showed that folic acid targeted nanoparticles were internalized specifically in a folate receptor dependent manner. In vivo study confirmed, that, considerable accumulation of nanosystems was found compared with the control animal represented by the MR images. Relaxometry measurements demonstrated that the nanoparticle-Gd complexes drastically change the signal intensity of the tumor cells. Because of the contrast enhancement, they are attractive candidates as potential contrast agents for a variety of diagnostic applications including early diagnosis of tumors.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Hajdu I,Bodnár M,Trencsényi G,Márián T,Vámosi G,Kollár J,Borbély Jdoi
10.1016/j.ijpharm.2012.11.038subject
Has Abstractpub_date
2013-01-30 00:00:00pages
234-41issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(12)01045-9journal_volume
441pub_type
杂志文章abstract::Development of novel anticancer formulations is a priority challenge in biomedicine. However, in vitro models based on monolayer cultures (2D) which are currently used for cytotoxicity tests leave much to be desired. More and more attention is focusing on 3D in vitro systems which can better mimic solid tumors. The ai...
journal_title:International journal of pharmaceutics
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pub_type: 临床试验,杂志文章,随机对照试验
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