Abstract:
:The role of curcumin (diferuloylmethane), for cancer treatment has been an area of growing interest. However, due to its low absorption, the poor bioavailability of curcumin limits its clinical use. In this study, we reported an approach of encapsulation a curcumin by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound. We demonstrated that liposomal preparations to deliver curcumin increase its bioavailability. Liposomes composed of salmon's lecithin also improved curcumin bioavailability compared to those constituted of rapeseed and soya lecithins. A real-time label-free cell analysis system based on real-time cell impedance monitoring was used to investigate the in vitro cytotoxicity of liposomal preparations.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Hasan M,Belhaj N,Benachour H,Barberi-Heyob M,Kahn CJ,Jabbari E,Linder M,Arab-Tehrany Edoi
10.1016/j.ijpharm.2013.12.007subject
Has Abstractpub_date
2014-01-30 00:00:00pages
519-28issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(13)01075-2journal_volume
461pub_type
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