当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Assessment of disorder in crystalline powders--a review of analytical techniques and their application.

Assessment of disorder in crystalline powders--a review of analytical techniques and their application.

Abstract：

:The need to be able to measure amorphous contents in crystalline powders is now recognised. In this review, calorimetric and gravimetric methods are reviewed in a way that should alert workers in the field to the theoretical, and practical considerations which are important to understanding how best to study crystalline samples which contain low levels of amorphous material. It is shown that vapour sorption techniques are very powerful as long as serious consideration is given to the choice of environmental conditions and the exact experimental methodology. As the amount of published work in this field grows, it becomes increasingly necessary to describe experimental and data manipulation methods in great detail.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Buckton G,Darcy P

doi

10.1016/s0378-5173(98)00335-4

keywords:

subject

Has Abstract

pub_date

1999-03-15 00:00:00

pages

141-58

issue

2

eissn

0378-5173

issn

1873-3476

pii

S0378517398003354

journal_volume

179

pub_type

杂志文章,评审

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • In vitro skin penetration enhancement techniques: A combined approach of ethosomes and microneedles.

    abstract：:Dermal administration of different macromolecules, such as nucleic acids, remains a real challenge because of the difficulty of crossing the main skin barrier, the stratum corneum (SC). To overcome this barrier, the use of deformable lipid-based nanovectors were developed to increase topical penetration through the SC...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118793

    authors： Bellefroid C,Lechanteur A,Evrard B,Mottet D,Debacq-Chainiaux F,Piel G

    更新日期：2019-12-15 00:00:00

  • Downstream drug product processing of itraconazole nanosuspension: Factors influencing drug particle size and dissolution from nanosuspension-layered beads.

    abstract：:There is more research required to broaden the knowledge on the downstream processing of nanosuspensions into solid oral dosage forms, especially for coated nanosuspensions onto beads as carriers. This study focuses on bead layering as one approach to solidify nanosuspensions. The aim was to systematically investigate...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.04.012

    authors： Parmentier J,Tan EH,Low A,Möschwitzer JP

    更新日期：2017-05-30 00:00:00

  • Determination of acetaminophen's solubility in poly(ethylene oxide) by rheological, thermal and microscopic methods.

    abstract：:A drug's solubility in a polymeric excipient is an important parameter that dictates the process window of hot-melt extrusion (HME) and product stability during storage. However, it is rather challenging to experimentally determine the solubility and there is very few published work in this field. In this study, the s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.10.026

    authors： Yang M,Wang P,Suwardie H,Gogos C

    更新日期：2011-01-17 00:00:00

  • Investigation of surfactants suitable for stabilizing of latanoprost.

    abstract：:The content of latanoprost, a therapeutic drug for glaucoma, is likely to decrease in solution. In a previous study, we confirmed that this was associated with latanoprost adsorption to the container and hydrolysis of latanoprost, and established a formulation of latanoprost eye drop solution that can be stored at roo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.027

    authors： Ochiai A,Ohkuma M,Danjo K

    更新日期：2012-10-15 00:00:00

  • Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system.

    abstract：:The aim of this study was to generate a new type of nanoparticles made of chitosan (CS) and carboxymethyl-beta-cyclodextrin (CM-beta-CD) and to evaluate their potential for the association and delivery of macromolecular drugs. CS and CM-beta-CD or mixtures of CM-beta-CD/tripolyphosphate (TPP) were processed to nanopar...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.03.005

    authors： Krauland AH,Alonso MJ

    更新日期：2007-08-01 00:00:00

  • Leaching of pectin from mixed films containing pectin, chitosan and HPMC intended for biphasic drug delivery.

    abstract：:Mixed films containing pectin, chitosan and HPMC, prepared by solvent casting from 0.1 M HCl (pH 1.5) and 0.1 M acetic acid (pH 2.9) were evaluated for their morphological and leaching properties. Films cast at pH 1.5 were uniform with smooth surfaces while films cast at pH 2.9 showed particle aggregation and had roug...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00546-x

    authors： Ofori-Kwakye K,Fell JT

    更新日期：2003-01-02 00:00:00

  • Herceptin-functionalized pure paclitaxel nanocrystals for enhanced delivery to HER2-postive breast cancer cells.

    abstract：:The objective of this study was to prepare Herceptin (HCT)-functionalized paclitaxel nanocrystals and evaluated their cell-specific interactions, cellular accumulation, and growth inhibition in HER2-positve breast cancer cells as a tumor-targeted delivery module. Paclitaxel (PTX) was fabricated in the form of nanocrys...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.09.067

    authors： Noh JK,Naeem M,Cao J,Lee EH,Kim MS,Jung Y,Yoo JW

    更新日期：2016-11-20 00:00:00

  • Preparation and evaluation of agglomerated crystals by crystallo-co-agglomeration: an integrated approach of principal component analysis and Box-Behnken experimental design.

    abstract：:Poor mechanical properties of crystalline drug particles require wet granulation technique for tablet production which is uneconomical, laborious, and tedious. The present investigation was aimed to improve flow and mechanical properties of racecadotril (RCD), a poorly water soluble antidiarrheal agent, by a crystallo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.04.073

    authors： Garala KC,Patel JM,Dhingani AP,Dharamsi AT

    更新日期：2013-08-16 00:00:00

  • A preliminary study for the development and optimization by experimental design of an in vitro method for prediction of drug buccal absorption.

    abstract：:The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp) through excised porci...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.06.032

    authors： Mura P,Orlandini S,Cirri M,Maestrelli F,Mennini N,Casella G,Furlanetto S

    更新日期：2018-08-25 00:00:00

  • Carrageenan-based physically crosslinked injectable hydrogel for wound healing and tissue repairing applications.

    abstract：:In this study, a novel injectable hydrogel based on iota and kappa carrageenan, locust bean gum and gelatin was prepared for wound healing and tissue repairing applications. This injectable hydrogel was obtained via physical crosslinking. FTIR analysis confirmed the physical interaction between the biopolymeric compon...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119828

    authors： Pettinelli N,Rodríguez-Llamazares S,Bouza R,Barral L,Feijoo-Bandín S,Lago F

    更新日期：2020-08-29 00:00:00

  • Advances of nanosystems containing cyclodextrins and their applications in pharmaceuticals.

    abstract：:For many years, researchers have worked with supramolecular structures involving inclusion complexes with cyclodextrins. These studies have resulted in new commercially available drugs which have been of great benefit. More recently, studies using nanoparticles, including nanosystems containing cyclodextrins, have bec...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2019.01.041

    authors： Menezes PDP,Andrade TA,Frank LA,de Souza EPBSS,Trindade GDGG,Trindade IAS,Serafini MR,Guterres SS,Araújo AAS

    更新日期：2019-03-25 00:00:00

  • Novel drug delivery systems for natural extracts: The case study of Vitis Vinifera extract-SiO2 nanocomposites.

    abstract：:Ball Milling technique has been used to prepare for the first time Vitis Vinifera extract-silica nanocomposites (VV-SiO2 NCs), which combine the pharmacological effects of the extract with the effectiveness of silica as drug delivery system and active component in the treatment of wound healing. Different contents (1....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.057

    authors： Scano A,Ebau F,Manca ML,Cabras V,Cesare Marincola F,Manconi M,Pilloni M,Fadda AM,Ennas G

    更新日期：2018-11-15 00:00:00

  • Formulation and in-vitro evaluation of directly compressed controlled release matrices of Losartan Potassium using Ethocel Grade 100 as rate retarding agent.

    abstract：:Current study was aimed to develop 200mg controlled release matrix tablets of Losartan Potassium using Ethocel 100 Premium and Ethocel 100 FP Premium as rate controlling polymer. In-vitro studies were performed according to USP Method-I in phosphate buffer (PH 6.8) using pharma test dissolution apparatus. The temperat...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.10.051

    authors： Khan KA,Khan GM,Zeeshan Danish M,Akhlaq,Khan H,Rehman F,Mehsud S

    更新日期：2015-12-30 00:00:00

  • Enhanced preclinical efficacy of tamoxifen developed as alginate-cysteine/disulfide bond reduced albumin nanoparticles.

    abstract：:Tamoxifen (TMX) is the most common clinical choice for the treatment of advanced or metastatic estrogen-dependent breast cancer. However, research on new challenging therapies is necessary due to its undesirable side effects and the limitation of the treatment only to the oral route. In this study, the antitumor activ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.045

    authors： Martínez A,Muñiz E,Iglesias I,Teijón JM,Blanco MD

    更新日期：2012-10-15 00:00:00

  • Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.

    abstract：:The purpose of this study was to construct microemulsion-base hydrogel formulation for topical delivery of ibuprofen. Ethyl oleate (EO) was screened as the oil phase of microemulsions, due to a good solubilizing capacity of the microemulison systems and excellent skin permeation rate of ibuprofen. The pseudo-ternary p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.02.015

    authors： Chen H,Chang X,Du D,Li J,Xu H,Yang X

    更新日期：2006-06-06 00:00:00

  • MALDI mass spectrometry imaging as a complementary analytical method for improved skin distribution analysis of drug molecule and excipients.

    abstract：:In cutaneous drug delivery, it is widely accepted that the choice of excipients affects the delivery of a drug molecule to the skin. MALDI mass spectrometry imaging (MALDI-MSI) is an imaging technique which enables the simultaneous detection of multiple compounds. MALDI-MSI was applied to study the penetration of tofa...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119949

    authors： Handler AM,Fallah M,Just Pedersen A,Pommergaard Pedersen G,Troensegaard Nielsen K,Janfelt C

    更新日期：2020-11-30 00:00:00

  • Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions.

    abstract：:Changes in the rheological properties of four o/w cream formulations differing in the combination of surfactants were studied. The non-ionic surfactants used were soybean derivatives, polyethylene glycol 10 and 25 soya sterol, and sorbitol derivatives, sorbitan monooleate and trioleate. Combinations of the soybean and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(01)00675-5

    authors： Korhonen M,Hellen L,Hirvonen J,Yliruusi J

    更新日期：2001-06-19 00:00:00

  • Development of Ussing model coupled with artificial membrane for predicting intestinal absorption mechanisms of drugs.

    abstract：:The absorption mechanisms of drugs play an important role on development and various application of drugs. However, the present methods of absorption mechanisms are not perfect enough. Hence, exploring a novel method to accurately predict the absorption mechanisms is necessary. In this study, we developed an Ussing mo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119170

    authors： Huang S,Huang Y,Yin X,Wang D,Xiang W,Wang M,Xia Z

    更新日期：2020-04-15 00:00:00

  • Combination of PLGA nanoparticles with mucoadhesive guar-gum films for buccal delivery of antihypertensive peptide.

    abstract：:Oral administration of proteins and peptides still is a challenging task to overcome due to low permeability through absorptive epithelia, degradation and metabolism that lead to poor bioavailability. Attempting to overcome such limitations, an antihypertensive peptide derived from whey protein, with KGYGGVSLPEW seque...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.05.051

    authors： Castro PM,Baptista P,Madureira AR,Sarmento B,Pintado ME

    更新日期：2018-08-25 00:00:00

  • Roll compaction process modeling: transfer between equipment and impact of process parameters.

    abstract：:In this study, the roll compaction of an intermediate drug load formulation was performed using horizontally and vertically force fed roll compactors. The horizontally fed roll compactor was equipped with an instrumented roll technology allowing the direct measurement of normal stress at the roll surface, while the ve...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.02.042

    authors： Souihi N,Reynolds G,Tajarobi P,Wikström H,Haeffler G,Josefson M,Trygg J

    更新日期：2015-04-30 00:00:00

  • Gastro-floating tablets of cephalexin: preparation and in vitro/in vivo evaluation.

    abstract：:Gastro-floating tablets of cephalexin were developed to prolong the residence time in major absorption sites. Gastro-floating tablets were prepared and optimized using hydroxypropyl methylcellulose (HPMC K100M) as matrix and sodium bicarbonate as a gas-forming agent. The properties of the tablets in terms of floating ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.05.011

    authors： Yin L,Qin C,Chen K,Zhu C,Cao H,Zhou J,He W,Zhang Q

    更新日期：2013-08-16 00:00:00

  • In vitro and in vivo release of dinalbuphine sebacate extended release formulation: Effect of the oil ratio on drug release.

    abstract：:Nalbuphine is a semi-synthetic opioid indicated for the relief of moderate to severe pain. Dinalbuphine sebacate (DNS) is a prodrug of nalbuphine for which we have developed long-acting lipophilic formulations in a benzyl benzoate/sesame oil mixture for intramuscular (IM) injection. In this study, we found that the in...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.08.083

    authors： Li CJ,Ku MY,Lu CY,Tien YE,Chern WH,Huang JD

    更新日期：2017-10-05 00:00:00

  • In vitro and in vivo evaluation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matrices.

    abstract：:The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral absorption study, and compared with a commercial product (slow-K). The results indicating ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00264-8

    authors： Wu PC,Tsai MJ,Huang YB,Chang JS,Tsai YH

    更新日期：2002-08-28 00:00:00

  • Dual-responsive lidocaine in situ gel reduces pain of intrauterine device insertion.

    abstract：:The most effective and safe contraceptive method, intrauterine devices (IUDs), is still underutilized due to the pain barrier during IUD insertion. Lidocaine, a well-known local anesthetic, can be used to relieve IUD insertion pain. This study aimed at formulation, in vitro, in vivo and clinical evaluation of a novel ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2018.01.033

    authors： Abd Ellah NH,Abouelmagd SA,Abbas AM,Shaaban OM,Hassanein KMA

    更新日期：2018-03-01 00:00:00

  • Swelling, melting point reduction and solubility of PEG 1500 in supercritical CO2.

    abstract：:The knowledge of the solubility of PEG 1500 as well as the swelling and melting point variation in supercritical CO(2) in a relatively high-pressure range is a necessary prerequisite to set-up pharmaceutical processes dealing with the polymer in the molten state. Experiments carried out in a pressurized view cell indi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.048

    authors： Pasquali I,Comi L,Pucciarelli F,Bettini R

    更新日期：2008-05-22 00:00:00

  • Relating the tableting behavior of piroxicam polytypes to their crystal structures using energy-vector models.

    abstract：:Piroxicam crystallises into two polytypes, α1 and α2, with crystal structures that contain identical molecular layers but differ in the way that these layers are stacked. In spite of having close structural similarity, the polytypes have significantly different powder tabletting behaviour: α2 forms only weak tablets a...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.040

    authors： Upadhyay PP,Sun CC,Bond AD

    更新日期：2018-05-30 00:00:00

  • The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system.

    abstract：:Once introduced into physiological environment, nanoparticles (NPs) are immediately coated with proteins, resulting in formation of what is known as protein corona. The formation of protein corona can be affected by many factors. Likewise, the addition of protein corona can alter the physicochemical properties and bio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2018.10.011

    authors： Xiao W,Gao H

    更新日期：2018-12-01 00:00:00

  • Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure.

    abstract：:The two polyhydroxy surfactants polyglycerol 6-distearate (Plurol(®)Stearique WL1009 - (PS)) and caprylyl/capryl glucoside (Plantacare(®) 810 - (PL)) are a class of PEG-free stabilizers, made from renewable resources. They were investigated for stabilization of aqueous solid lipid nanoparticle (SLN) and nanostructured...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.12.036

    authors： Kovacevic A,Savic S,Vuleta G,Müller RH,Keck CM

    更新日期：2011-03-15 00:00:00

  • Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice.

    abstract：:Despite the great advances accomplished in the treatment of pediatric cancers, recurrences and metastases still exacerbate prognosis in some aggressive solid tumors such as neuroblastoma and osteosarcoma. In view of the poor efficacy and toxicity of current chemotherapeutic treatments, we propose a single multitherape...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119345

    authors： Rodríguez-Nogales C,Mura S,Couvreur P,Blanco-Prieto MJ

    更新日期：2020-05-30 00:00:00

  • Non-viral gene delivery carrier and its three-dimensional transfection system.

    abstract：:An increasing number of non-viral vectors are being developed for the use of gene delivery nowadays, among which cationic polymers and lipoplexes receive most attention. Most of these researches are focused on how to increase the transfection efficiency of non-viral vectors as well as the reduction of toxicity. In thi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2009.11.006

    authors： He CX,Tabata Y,Gao JQ

    更新日期：2010-02-15 00:00:00