Abstract：
:Once introduced into physiological environment, nanoparticles (NPs) are immediately coated with proteins, resulting in formation of what is known as protein corona. The formation of protein corona can be affected by many factors. Likewise, the addition of protein corona can alter the physicochemical properties and biodistribution of NPs. NPs with the coating protein corona can be considered as a biological identity that recognized by cells in biological system. Thus, to understand and regulate the effect of protein corona on targeting capability of NPs in vivo, it is necessary to elucidate the interaction between the NPs and the biological fluid. In this review, we first elucidate the factors influencing the formation of protein corona, including NPs physicochemical factors, such as NPs composition, size, shape, surface chemistry, etc., and environmental factors, such as environmental temperature, protein origins, etc. Then, we focus on the effect of protein corona on the passive targeting and active targeting, and discuss the probable reasons that causing the discrepant results. Finally, we review the strategies for tuning the protein corona to promote targeting, including reducing protein adsorption and recruiting specific proteins.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Xiao W,Gao Hdoi
10.1016/j.ijpharm.2018.10.011subject
Has Abstractpub_date
2018-12-01 00:00:00pages
328-339issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(18)30747-6journal_volume
552pub_type
杂志文章,评审abstract：:Directly compressed theophylline tablets, containing commercial xanthan (X) (Keltrol) and a highly hydrophilic galactomannan (G) from the seeds of Mimosa scabrella (a brazilian leguminous tree called bracatinga) as release-controlling agents, were obtained. Gums were used at 4, 8, 12.5 and 25% (w/w), either alone or i...
journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2012.05.050
更新日期：2012-09-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2002-02-21 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2009-08-13 00:00:00
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journal_title：International journal of pharmaceutics
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更新日期：2009-01-21 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2008.06.027
更新日期：2008-11-03 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2016-09-10 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2014-04-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
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更新日期：2014-11-20 00:00:00
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pub_type： 杂志文章
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更新日期：2013-11-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2020-05-30 00:00:00
