Abstract：
:The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral absorption study, and compared with a commercial product (slow-K). The results indicating that the release rates of potassium from experimental formulations were dependent on the type of semi-solid matrices (Gelucires). The higher the melting point of the Gelucires was incorporated, the slower release rate of the active substance was observed. Moreover, the values of similarity factor of Formulae F05 and F09 versus the reference in three kinds of dissolution medium (f(2)) were higher than 50, indicating that these experimental formulations had similar sustained release effects to the reference (slow-K) in dissolution test. In vivo study, the cumulative amount (mEq) of potassium excreted curve and the excretion rate curve of F05 and F09 were found to be similar to that of slow-K, and there were no significant differences (P > 0.05) in the maximum excretion rate and the mean time to reach the maximum rate between formulations and slow-K, indicating that the potassium chloride sustained release dosage form could be prepared using the Gelucires as lipid excipients.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Wu PC,Tsai MJ,Huang YB,Chang JS,Tsai YHdoi
10.1016/s0378-5173(02)00264-8keywords:
subject
Has Abstractpub_date
2002-08-28 00:00:00pages
119-24issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517302002648journal_volume
243pub_type
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