Abstract：
:Dosage forms with fixed dose combinations of drugs is a frequent and advantageous mode of administration, but their production involves a number of technological problems. Numerous interactions in a homogeneous vehicle may be avoided through the use of layered tablets. The mechanical properties of these dosage forms depend on numerous process parameters and material characteristics. The aim of the present study was a detailed investigation of the relationships between the surface characteristics and deformation properties of tableting materials and the tendency of bilayer tablets to undergo lamination. Bilayer tablets were compressed from unlubricated materials with different plastic-elastic properties and surface free energies according to a mixed 2 and 3-level half-replicated factorial design. The results revealed that the surface characteristics play the main role in the lamination of layered tablets and the effect of the plastic-elastic behavior cannot be interpreted without a knowledge of these properties.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Papós K,Kása P Jr,Ilič I,Blatnik-Urek S,Regdon G Jr,Srčič S,Pintye-Hódi K,Sovány Tdoi
10.1016/j.ijpharm.2015.10.061subject
Has Abstractpub_date
2015-12-30 00:00:00pages
609-13issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(15)30331-8journal_volume
496pub_type
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