Abstract:
:A series of mesocellular foams (MCFs)-based mesoporous silica nanospheres (DH-MCF-P123-n, (n=12, 2, 0.5)) were synthesized as controlled-release deliveries for a typical antidepressant drug, venlafaxine. The foams were 3-(2,3-dihydroxypropoxyl)propyl-grafted and the P123 template partially preserved. We studied the release profiles of venlafaxine-loaded DH-MCF-P123-n in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), respectively, as well as their corresponding venlafaxine loading capacities. Appropriate amounts of P123 template preserved in mesopores showed an efficient synergetic effect on increasing venlafaxine loading capacity and controlled-release property. Up to 90.87% (mass fraction) of venlafaxine could be loaded into DH-MCF-P123-2. For this carrier, 36% of venlafaxine was released after 1h of incubation in SGF and 53% of venlafaxine was released after 12h in SIF. The mechanisms of the loading and releasing processes were tentatively described based on the release behaviors.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tang J,Bian Z,Hu J,Xu S,Liu Hdoi
10.1016/j.ijpharm.2011.12.048subject
Has Abstractpub_date
2012-03-15 00:00:00pages
89-97issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)01178-1journal_volume
424pub_type
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