Abstract：
:The present work introduces a simple and robust in vitro method for enzymatic characterisation of surface properties of lipid dispersions in aqueous media. The initial lipolysis rate in biorelevant media, using pancreatic lipase and a self-microemulsifying formulation (SMEDDS) containing digestible lipids as substrate, was determined. The impact of incorporating two sparingly water soluble model drugs, probucol and halofantrine, into the SMEDDS was studied. It was found that both model drugs reduced the initial rate of lipolysis compared with the vehicle, probucol having a larger effect than halofantrine. The reduction of initial lipolysis rate indicates that probucol and halofantrine are bound in the water/emulsion interface limiting the substrate availability.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Ljusberg-Wahren H,Seier Nielsen F,Brogård M,Troedsson E,Müllertz Adoi
10.1016/j.ijpharm.2005.02.038keywords:
subject
Has Abstractpub_date
2005-07-25 00:00:00pages
328-32issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(05)00241-3journal_volume
298pub_type
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