Pharmacokinetic study of a carbamazepine nanoemulsion in beagle dogs.

abstract：:The pharmacokinetic parameters of nitrendipine were determined in 40 healthy male volunteers and a very high degree of intersubject variability was observed (CV = 39-71%). Since the distribution of nitrendipine to erythrocytes could influence the overall pharmacokinetic variability the correlation between hematocrit a...

journal_title：International journal of pharmaceutics

authors： Antolic G,Kozjek F,Primozic S

更新日期：2001-03-14 00:00:00

abstract：:The simultaneous skin permeation of drug and penetration enhancer have been studied in vitro. Simple formulations of mefenamic acid in PEG400 incorporating various proportions of ethanol or 1,8-cineole were prepared and applied to porcine ear skin in diffusion cells under infinite conditions. Receptor phases were assa...

journal_title：International journal of pharmaceutics

authors： Heard CM,Kung D,Thomas CP

更新日期：2006-09-14 00:00:00

abstract：:Different types of Carbopols are frequently applied excipients of various dosage forms. Depending on the supramolecular structure, their water sorption behaviour could significantly differ. The purpose of the present study was to track the supramolecular changes of two types of Carbopol polymers (Carbopol 71G and Ultr...

journal_title：International journal of pharmaceutics

authors： Szabó B,Süvegh K,Zelkó R

更新日期：2011-09-15 00:00:00

abstract：:Matrix metalloproteinases (MMPs) overexpression plays a critical role in cancer invasion and metastasis. We utilized this key feature of tumor microenvironment to develop a disease-stimuli triggered drug delivery system. Poly(acrylic acid) hydrogels were synthesized by UV polymerization and pendant MMP-2 sensitive pep...

journal_title：International journal of pharmaceutics

authors： Zhang Y,Gemeinhart RA

更新日期：2012-06-15 00:00:00

abstract：:The purpose of this study was to investigate the effect of heparin conjugation to the surface of doxorubicin (DOX)-loaded liposomes on the circulation time, biodistribution and antitumor activity after intravenous injection in murine B16F10 melanoma tumor-bearing mice. The heparin-conjugated liposomes (heparin-liposom...

journal_title：International journal of pharmaceutics

authors： Han HD,Lee A,Song CK,Hwang T,Seong H,Lee CO,Shin BC

更新日期：2006-04-26 00:00:00

abstract：:Rifampicin is a first-line, highly effective drug currently used orally as a part of a lengthy multi-drug regimen against tuberculosis (TB). Despite the potential of inhaled therapy as an effective approach for TB treatment, an inhalable formulation of rifampicin has not yet been developed for clinical use. In order t...

journal_title：International journal of pharmaceutics

authors： Khadka P,Hill PC,Zhang B,Katare R,Dummer J,Das SC

更新日期：2020-09-25 00:00:00

abstract：:The mechanical properties of casted Eudragit E-100 films were tested for the combined effect of two cohesion promoters (succinic or citric acid) and triacetin as a plasticizer. The prepared films were elastic, self-adhesive, transparent and pale yellow in colour. Films containing either of the tested cohesion promoter...

journal_title：International journal of pharmaceutics

authors： Elgindy N,Samy W

更新日期：2009-07-06 00:00:00

abstract：:Selective relaxation rate measurements effectively proved the affinity of dexamethasone 21-phosphate disodium salt for quaternary ammonium-chitosan conjugates, their thiolated derivatives and the corresponding nanostructured aggregates. Affinity was also probed by dynamic dialysis. The release profile of dexamethasone...

journal_title：International journal of pharmaceutics

authors： Uccello-Barretta G,Balzano F,Aiello F,Senatore A,Fabiano A,Zambito Y

更新日期：2014-01-30 00:00:00

abstract：:Despite that in solution we cannot detect the interaction between Ni(2+) and mitoxantrone (MIT), Ni(2+) could mediate effective and stable MIT loading into large unilamellar vesicles (LUVs). The presence of nigericin had almost no influences on MIT encapsulation. However, in the presence of NH(3), the drug loading kin...

journal_title：International journal of pharmaceutics

authors： Cui J,Li C,Wang L,Wang C,Yang H,Li Y,Zhang L,Zhang L,Guo W,Liang M

更新日期：2009-02-23 00:00:00

abstract：:The static electricity generated by triggering a piezo gas igniter is shown to cause electroporation of the skin to deliver antigen. Mice were immunized with chicken albumin by electroporation using a piezo gas igniter and in another experiment, the gas igniter was replaced by a power supply. In both the groups identi...

journal_title：International journal of pharmaceutics

authors： Upadhyay P

更新日期：2001-04-17 00:00:00

abstract：:Amphotericin B (AmB) has a broad antifungal and leishmanicidal activity with low incidence of clinical resistance. Its parenteral administration has high risk of nephrotoxicity that limits its use. In order to treat cutaneous infections, AmB topical administration is a safer therapy because of the low systemic absorpt...

journal_title：International journal of pharmaceutics

authors： Ruiz HK,Serrano DR,Dea-Ayuela MA,Bilbao-Ramos PE,Bolás-Fernández F,Torrado JJ,Molero G

更新日期：2014-10-01 00:00:00

abstract：:Docetaxel (DTX) is one of the important antitumor drugs, being used in several common chemotherapies to control leading cancer types. Severe toxicities of the DTX are prominent due to sudden parenteral exposure of desired loading dose to maintain the therapeutic concentration. Field of nanotechnology is leading to res...

journal_title：International journal of pharmaceutics

authors： Choudhury H,Gorain B,Pandey M,Kumbhar SA,Tekade RK,Iyer AK,Kesharwani P

更新日期：2017-08-30 00:00:00

abstract：:Plastic bags and tubes are increasingly used for the storage and application of pharmaceutical formulations. The most common polymer material for drug application sets is plasticized poly(vinylchloride) (PVC). During application of pharmaceutical drug solution through PVC tubes, the polymer and the contact media inter...

journal_title：International journal of pharmaceutics

authors： Treleano A,Wolz G,Brandsch R,Welle F

更新日期：2009-03-18 00:00:00

abstract：:Insulin has been encapsulated in poly(lactic-co-glycolic acid) (PLGA) microspheres by solid-in-oil-in-oil (S/O/O) emulsion technique using DMF/corn oil as new solvent pairs. To get better encapsulation efficiency, insulin nanoparticles were prepared by the modified isoelectric point precipitation method so that it had...

journal_title：International journal of pharmaceutics

authors： Han Y,Tian H,He P,Chen X,Jing X

更新日期：2009-08-13 00:00:00

abstract：:To reduce systemic bleeding risks during anticoagulant treatment, a new concept named "precise anticoagulation" was proposed to localize the effects of anticoagulants via the targeted delivery of prodrugs to the coagulation site. In this study, the fusion protein Annexin V-hirudin 3-ABD (hAvHA) was constructed to achi...

journal_title：International journal of pharmaceutics

authors： Han HH,Zhang HT,Wang R,Yan Y,Liu X,Wang Y,Zhu Y,Wang JC

更新日期：2020-09-10 00:00:00

abstract：:Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for...

journal_title：International journal of pharmaceutics

authors： Alama T,Katayama H,Hirai S,Ono S,Kajiyama A,Kusamori K,Katsumi H,Sakane T,Yamamoto A

更新日期：2016-12-30 00:00:00

abstract：:Poorly water-soluble drug substances that exhibit high melting points are difficult to process by melt extrusion due to chemical instability at high temperatures required for processing. The purpose of this study was to extrude meloxicam (melting point 255°C) by optimizing processing parameters and formulation composi...

journal_title：International journal of pharmaceutics

authors： Haser A,Huang S,Listro T,White D,Zhang F

更新日期：2017-05-30 00:00:00

abstract：:The effects of addition of divalent cations and phosphate buffer on the degree of beta-carotene encapsulation in a mannitol matrix during freeze-drying were analyzed. The degradation rate of encapsulated beta-carotene as a function of % RH and its relationship with the physical state of the matrix during storage at 25...

journal_title：International journal of pharmaceutics

authors： Sutter SC,Buera MP,Elizalde BE

更新日期：2007-03-06 00:00:00

abstract：:The objective was to quantify drug loss due to cold flow (CF) in marketed estradiol transdermal drug delivery systems (TDDS), and study its influence on the in vitro flux and drug transfer across contacting skin. TDDS samples (products-A and B) were induced with CF at 25 and 32°C/60% RH by applying 1-kg force for 72h....

journal_title：International journal of pharmaceutics

authors： Krishnaiah YS,Yang Y,Hunt RL,Khan MA

更新日期：2014-12-30 00:00:00

abstract：:This review article is focused on the sterilization techniques used for polymer-based implantable medical devices as well as the regulatory aspects governing sterile medical devices. Polymeric materials are increasingly used in implantable devices due to their biodegradable and biocompatible nature. Patients and medic...

journal_title：International journal of pharmaceutics

authors： Tipnis NP,Burgess DJ

更新日期：2018-06-15 00:00:00

abstract：:A physiologically pertinent in vitro model is urgently needed for probing interactions between inhaled drugs and the organic cation transporters (OCT) in the bronchial epithelium. This study evaluated OCT expression, functionality, inhibition by common inhaled drugs and impact on formoterol transepithelial transport i...

journal_title：International journal of pharmaceutics

authors： Mukherjee M,Pritchard DI,Bosquillon C

更新日期：2012-04-15 00:00:00

abstract：:Subcutaneous vaccination of C57bl/6 mice with irradiated B16 melanoma cells supplemented with liposomal interleukin-2 (IL2) or murine interferon-gamma (mIFNgamma), resulted in systemic protection in 50% of the animals, against a subsequent tumor cell challenge in a dose dependent manner. The protective efficacy was co...

journal_title：International journal of pharmaceutics

authors： van Slooten ML,Kircheis R,Koppenhagen FJ,Wagner E,Storm G

更新日期：1999-06-10 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a fungal disease of the lung associated with high mortality rates in immunosuppressed patients despite treatment. Targeted drug delivery of aqueous voriconazole solutions has been shown in previous studies to produce high tissue and plasma drug concentrations as well as improv...

journal_title：International journal of pharmaceutics

authors： Tolman JA,Nelson NA,Bosselmann S,Peters JI,Coalson JJ,Wiederhold NP,Williams RO 3rd

更新日期：2009-09-08 00:00:00

abstract：:Econazole is a commonly used azole antifungal in clinical treatment of superficial fungal infections. It is generally used as conventional cream and gel preparations under the brand names of Spectazole (United States), Ecostatin (Canada), Pevaryl (Western Europe). Treatment efficiency of antifungal drugs depends on th...

journal_title：International journal of pharmaceutics

authors： Firooz A,Nafisi S,Maibach HI

更新日期：2015-11-10 00:00:00

abstract：:Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective again...

journal_title：International journal of pharmaceutics

authors： Gaubert A,Kauss T,Marchivie M,Ba BB,Lembege M,Fawaz F,Boiron JM,Lafarge X,Lindegardh N,Fabre JL,White NJ,Olliaro PL,Millet P,Grislain L,Gaudin K

更新日期：2014-07-01 00:00:00

abstract：:Over the last few decades, hot melt extrusion (HME) has emerged as a successful technology for a broad spectrum of applications in the pharmaceutical industry. As indicated by multiple publications and patents, HME is mainly used for the enhancement of solubility and bioavailability of poorly soluble drugs. This revie...

journal_title：International journal of pharmaceutics

authors： Repka MA,Bandari S,Kallakunta VR,Vo AQ,McFall H,Pimparade MB,Bhagurkar AM

更新日期：2018-01-15 00:00:00

abstract：:The Higuchi model for the rate of drug release from matrix devices where the drug loading exceeds the solubility in the matrix medium, whose 50-year anniversary is celebrated in this issue, has proven to be a robust framework and an invaluable tool in developing a significant part of the modern controlled drug deliver...

journal_title：International journal of pharmaceutics

authors： Paul DR

更新日期：2011-10-10 00:00:00

abstract：:The development of a single-dose tetanus vaccine based on Poly(Lactic acid) (PLA) or Poly(Lactide-co-Glycolide) (PLGA) microspheres has been complicated due to the instability of tetanus toxoid (TT) inside these systems. Herein we report an attempt to re-design PLGA microspheres by co-encapsulating TT in the dry solid...

journal_title：International journal of pharmaceutics

authors： Sánchez A,Villamayor B,Guo Y,McIver J,Alonso MJ

更新日期：1999-08-20 00:00:00

abstract：:Oxidative stress has been implicated in the progression of age-related macular degeneration (AMD). Treatment with antioxidants seems to delay progression of AMD. In this study, we suggested an antioxidant delivery system based on redox-sensitive liposome composed of phospholipids and a diselenide centered alkyl chain....

journal_title：International journal of pharmaceutics

authors： Behroozi F,Abdkhodaie MJ,Abandansari HS,Satarian L,Ashtiani MK,Jaafari MR,Baharvand H

更新日期：2018-09-05 00:00:00

abstract：:In attempts to avoid the systemic side effects of piroxicam (PC) (e.g. gastrotoxicity), several buccal gel formulations containing PC were prepared and their effects on the characteristics of the drug permeation through rabbit buccal mucosa in-vitro were evaluated using a Franz-type diffusion cell. The general rank or...

journal_title：International journal of pharmaceutics

authors： Attia MA,El-Gibaly I,Shaltout SE,Fetih GN

更新日期：2004-05-19 00:00:00