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Recent advances in TPGS-based nanoparticles of docetaxel for improved chemotherapy.

Abstract：

:Docetaxel (DTX) is one of the important antitumor drugs, being used in several common chemotherapies to control leading cancer types. Severe toxicities of the DTX are prominent due to sudden parenteral exposure of desired loading dose to maintain the therapeutic concentration. Field of nanotechnology is leading to resist sudden systemic exposure of DTX with more specific delivery to the site of cancer. Further nanometric size range of the formulation aid for prolonged circulation, thereby extensive exposure results better efficacy. In this article, we extensively reviewed the therapeutic benefit of incorporating d-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS, or simply TPGS) in the nanoparticle (NP) formulation of DTX for improved delivery, tumor control and tolerability. TPGS is well accepted nonionic-ampiphilic polymer which has been identified in the role of emulsifier, stabilizer, penetration enhancer, solubilizer and in protection in micelle. Simultaneously, P-glycoprotein inhibitory activity of TPGS in the multidrug resistant (MDR) cancer cells along with its apoptotic potential are the added advantage of TPGS to be incorporated in nano-chemotherapeutics. Thus, it could be concluded that TPGS based nanoparticulate application is an advanced approach to improve therapeutic efficacy of chemotherapeutic agents by better internalization and sustained retention of the NPs.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Choudhury H,Gorain B,Pandey M,Kumbhar SA,Tekade RK,Iyer AK,Kesharwani P

doi

10.1016/j.ijpharm.2017.07.018

subject

Has Abstract

pub_date

2017-08-30 00:00:00

pages

506-522

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(17)30617-8

journal_volume

529

pub_type

杂志文章,评审

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