Novel drug delivery strategies for improving econazole antifungal action.

Abstract:

:Econazole is a commonly used azole antifungal in clinical treatment of superficial fungal infections. It is generally used as conventional cream and gel preparations under the brand names of Spectazole (United States), Ecostatin (Canada), Pevaryl (Western Europe). Treatment efficiency of antifungal drugs depends on their penetration through target layers of skin at effective concentrations. Econazole's poor water solubility limits its bioavailability and antifungal effects. Therefore, formulation strategies have been examined for delivering econazole through targeted skin sites. The present overview focuses on novel nano-based formulation approaches used to improve econazole penetration through skin for treatment of superficial fungal infections.

journal_name

Int J Pharm

authors

Firooz A,Nafisi S,Maibach HI

doi

10.1016/j.ijpharm.2015.09.015

subject

Has Abstract

pub_date

2015-11-10 00:00:00

pages

599-607

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)30213-1

journal_volume

495

pub_type

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