Abstract：
:Recently, we synthesized novel amphiphilic gelatin-oleic acid (GO) conjugate to prepare self-assembled nanoparticles for drug delivery. The aim of this study was to investigate pharmaceutical potentialities of self-assembled GO nanoparticles for solubility enhancement and modified release of poorly water-soluble drugs. Three poorly water-soluble model drugs with different pH-dependent solubility (valsartan and aceclofenac, insoluble at pH 1.2; telmisartan, insoluble at pH 6.8) were chosen to investigate the potential contributions of self-assembled GO nanoparticles to solubility enhancement and controlled release. The particle size of the drug-loaded nanoparticles was 200-250 nm. Zeta potential was calculated, and instrumental analysis such as powder X-ray diffraction (PXRD) and Fourier transform infrared (FT-IR) spectroscopy were used to investigate the physicochemical properties of the drug-loaded nanoparticles. Compared to the drug alone, the drug-loaded nanoparticles showed enhanced solubility. Furthermore, the release profiles of the model drugs were modified in a controlled manner. The current self-assembled GO nanoparticles can provide a versatile potential in drug delivery and tumor targeting.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tran PH,Tran TT,Lee BJdoi
10.1016/j.ijpharm.2013.07.025subject
Has Abstractpub_date
2013-10-15 00:00:00pages
235-40issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(13)00630-3journal_volume
455pub_type
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journal_title：International journal of pharmaceutics
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2014-03-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2016-11-30 00:00:00
