Abstract：
:Polysaccharides-based delivery systems and interpolyelectrolyte complexes (IPECs) are interesting alternatives to control the release of drugs, thereby improving therapies. Benznidazole (BZ) is the selected drug for Chagas disease pharmacotherapy. However, its side effects limit its efficacy and safety. We developed novel multiparticulated BZ-loaded IPECs based on chitosan and alginic acid, and investigated their physicochemical and pharmacotechnical properties. IPECs were obtained using the casting solvent method, followed by wet granulation. They presented ionic interaction between the biopolymers, revealed that free BZ was uniformly distributed and showed adequate flow properties for hard gelatin-capsule formulation. The multiparticles exhibited mucoadhesion properties and revealed modulation of BZ release, depending on the release media, in accordance with the fluid uptake. The IPECs developed possess interesting properties that are promising for the design of novel alternatives to improve Chagas disease pharmacotherapy, which would diminish BZ's adverse effects and/or allow a reduction in the frequency of BZ administration.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
García MC,Manzo RH,Jimenez-Kairuz Adoi
10.1016/j.ijpharm.2018.05.017subject
Has Abstractpub_date
2018-07-10 00:00:00pages
366-377issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(18)30309-0journal_volume
545pub_type
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