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Effects of conditions for preparing nanoparticles composed of aminoethylcarbamoyl-beta-cyclodextrin and ethylene glycol diglycidyl ether on trap efficiency of a guest molecule.

Abstract：

:Nanoparticles comprising copolymers of aminoethylcarbamoyl-beta-cyclodextrin (AEC-beta-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25-10.0% (w/w) water and 5.0% (w/w) surfactant (MO-3S, tetraglycerin monoester, HLB 8.8), where simple particles are predominantly obtained when the water content is 1.0% and 5.0%. Notably, nano-size small particles (diameter: 0.3 microm) are formed under the condition of 5.0% water and 5.0% surfactant, which have the highest beta-CD contents (75.5 wt.%) and the most positive zeta-potential (53.6 mV). The zeta-potential measurement indicates that the obtained particles have positive charge due to protonation of their amino groups below around pH 10. Actually, uptake of 8-anilino-1-naphthalenesulfonic acid (ANS) bearing negative charge (SO(3)(-)) and moderate hydrophobicity depends on the magnitude of zeta-potential of the particles; viz., the particles with zeta-potential of 53.6 mV show the highest efficiency of uptake. The diameter and the beta-CD contents are closely related with the water/surfactant ratio, and the zeta-potentials are dependent on both the diameter and the beta-CD contents. Inclusion of ANS into the CD cavity of EGDGE/AEC-beta-CD particles can be controlled by electrostatic interaction between ANS (negatively charged) and the particle (positively charged). Namely, synergistic effect of cavity-inclusion and electrostatic interaction can dominate the uptake of guest molecules by the particles.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Eguchi M,Du YZ,Ogawa Y,Okada T,Yumoto N,Kodaka M

doi

10.1016/j.ijpharm.2005.12.015

keywords:

subject

Has Abstract

pub_date

2006-03-27 00:00:00

pages

215-22

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(05)00849-5

journal_volume

311

pub_type

杂志文章

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