Preparation and optimization of fisetin loaded glycerol based soft nanovesicles by Box-Behnken design.


:The present study focused on the development and optimization of glycerosomes for dermal delivery of fisetin. The fisetin loaded glycerosomes formulation was optimized by Box-Behnken design. The independent variables were the lipoid S 100, glycerol, and sonication time, whereas the dependent variables were the vesicles size, entrapment efficiency, and flux. The mechanism of skin penetration of fisetin loaded glycerosomes formulation was determined by the DSC and FTIR studies. Confocal scanning microscopy was used to detect the penetration ability of glycerosomes. The optimized fisetin loaded glycerosomes formulation was converted into a Carbopol® gel matrix, and the latter was analyzed for various parameters. The optimized formulation of glycerosomes presented vesicles size, entrapment efficiency and flux of 138.8 ± 4.09 nm, 86.41 ± 2.95% and 5.04 ± 0.17 µg/cm2/h, respectively. The transmission electron microscopy of optimized fisetin loaded formulation revealed the spherical and sealed structure of glycerosomes vesicles. The confocal study confirmed that the Rhodamine B incorporated glycerosomes penetrated up to deeper layers of skin. The DSC and FTIR studies revealed that the hydration of skin layers and skin lipid fluidization could be the penetration mechanism of fisetin glycerosomes formulation. The optimized fisetin loaded glycerosomes gel formulation presented a flux of 4.24 ± 0.14 μg/cm2/h, and exhibited zero-order release kinetics. The texture analysis of fisetin glycerosomes gel displayed a sufficient hardness, consistency, cohesiveness, and index of viscosity. It was concluded that the prepared fisetin loaded glycerosomes gel was suitable for the dermal application.


Int J Pharm


Moolakkadath T,Aqil M,Ahad A,Imam SS,Praveen A,Sultana Y,Mujeeb M




Has Abstract


2020-03-30 00:00:00












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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Kuo YC,Cheng SJ

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


    authors: Korhonen M,Hellen L,Hirvonen J,Yliruusi J

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    authors: Li L,Leung SSY,Gengenbach T,Yu J,Gao GF,Tang P,Zhou QT,Chan HK

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    abstract::This review aims to give to the reader some new light on cyclodextrin (CD)-based theranostic agents in order to complete our recently published review dedicated to CD-particles conjugates in drug delivery systems (Zafar et al., 2014). CDs are biocompatible sugar-based macrocycles used in a wide range of biomedical app...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审


    authors: Zafar N,Fessi H,Elaissari A

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    pub_type: 杂志文章


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    authors: Wauthoz N,Hennia I,Ecenarro S,Amighi K

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    authors: Souihi N,Reynolds G,Tajarobi P,Wikström H,Haeffler G,Josefson M,Trygg J

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    authors: Hou J,Sun E,Sun C,Wang J,Yang L,Jia XB,Zhang ZH

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    abstract::The knowledge of the solubility of PEG 1500 as well as the swelling and melting point variation in supercritical CO(2) in a relatively high-pressure range is a necessary prerequisite to set-up pharmaceutical processes dealing with the polymer in the molten state. Experiments carried out in a pressurized view cell indi...

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    authors: Pasquali I,Comi L,Pucciarelli F,Bettini R

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  • Nanoparticle-based delivery of carbamazepine: A promising approach for the treatment of refractory epilepsy.

    abstract::Resistance to antiepileptic drugs (AEDs) is a major clinical problem. The overexpression of P-glycoprotein (Pgp), one of the main transporters limiting the entry of xenobiotics into the brain, is among the factors contributing to the AED resistance. Presently, there is no consensus on the interaction of carbamazepine ...

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    authors: Zybina A,Anshakova A,Malinovskaya J,Melnikov P,Baklaushev V,Chekhonin V,Maksimenko O,Titov S,Balabanyan V,Kreuter J,Gelperina S,Abbasova K

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    authors: Shaw LR,Irwin WJ,Grattan TJ,Conway BR

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  • Preparation of sustained-release nitrendipine microspheres with Eudragit RS and Aerosil using quasi-emulsion solvent diffusion method.

    abstract::Sustained-release nitrendipine microspheres were prepared in liquid system by quasi-emulsion solvent diffusion method, in which the Aerosil was employed as an inert dispersing carrier to improve the dissolution rate of nitrendipine, and Eudragit RS as a retarding agent to control the release rate. The resultant micros...

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  • Complexation of cationic-neutral block polyelectrolyte with insulin and in vitro release studies.

    abstract::Insulin (INS) was incorporated into complexes with the block polyelectrolyte quaternized poly[3,5-bis(dimethylaminomethylene)hydroxystyrene]-b-poly(ethylene oxide) (QNPHOSEO), which is a cationic-neutral block polyelectrolyte. Light scattering techniques are used in order to examine the size, the size distribution and...

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    authors: Pippa N,Karayianni M,Pispas S,Demetzos C

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  • Stabilization of gene delivery systems by freeze-drying.

    abstract::Freeze-drying of three different forms of gene delivery systems was performed using a controlled two-step drying process and 10% sucrose as lyoprotectant. Complexes of pCMVL plasmid with transferrin-conjugated polyethylenimine, adenovirus-enhanced transferrinfection consisting of pCMVL/transferrin-polylysine complexes...

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    authors: Talsma H,Cherng J,Lehrmann H,Kursa M,Ogris M,Hennink WE,Cotten M,Wagner E

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  • Understanding the structure and stability of paclitaxel nanocrystals.

    abstract::Previously, PTX/Pluronic F127 nanocrystals were prepared in our laboratory using the stabilization of nanocrystals (SNC) method. For PTX nanocrystals, dosages could be increased to yield improved antitumor activity over Taxol without incidence of acute toxicity. The objectives of this current study are to further unde...

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    authors: Merzlikine A,Abramov YA,Kowsz SJ,Thomas VH,Mano T

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    authors: Awwad S,Day RM,Khaw PT,Brocchini S,Fadda HM

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    authors: Makhlof A,Werle M,Tozuka Y,Takeuchi H

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Veiga F,Fernandes C,Teixeira F

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    pub_type: 杂志文章


    authors: Jannin V,Chevrier S,Michenaud M,Dumont C,Belotti S,Chavant Y,Demarne F

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    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Vaithiyalingam SR,Sayeed VA

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