Abstract：
:Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most widely prescribed drugs. Debilitating diseases such as rheumatoid arthritis and osteoarthritis are commonly managed by NSAIDs. However, NSAIDs pharmacological mechanism is often associated with the presence of gastrointestinal side effects. NSAIDs encapsulation is performed in order to overcome some of the drawbacks linked to their clinical use. To fulfill this purpose, various vectors like polymer-based nanoparticles, liposomes and solid lipid nanoparticles have been proposed. Such vehicles could have advantages but some limitations as well. This manuscript highlights current NSAIDs encapsulation approaches based on either preformed polymers or lipids. Moreover, properties of the prepared carriers and their applications are also discussed. Many factors are taken into account for selecting carrier type and encapsulation method. It was concluded that different vehicles and preparation methods have been employed for NSAIDs encapsulation. Mostly, vehicles sizes ranged within the nanoscale. Main advantages that have been confirmed by in vitro and in vivo studies include promoted stability, sustained release and bioavailability enhancement.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Badri W,Miladi K,Nazari QA,Greige-Gerges H,Fessi H,Elaissari Adoi
10.1016/j.ijpharm.2016.11.002subject
Has Abstractpub_date
2016-12-30 00:00:00pages
757-773issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(16)31053-5journal_volume
515pub_type
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