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Nanoincorporation of bioactive compounds from red grape pomaces: In vitro and ex vivo evaluation of antioxidant activity.

Abstract：

:In this study, the active components of grape pomaces were first extracted by maceration in ethanol and propylene glycol, then in extra virgin olive oil. The main components of the hydrophilic extractive solutions were flavonoids, while monounsaturated fatty acids were the most abundant constituents of the extractive oil, with high levels of oleic acid, which were identified by HPLC/DAD and GC/MS, respectively. The hydrophilic extractive solutions and the lipophilic extractive oil were used to prepare phospholipid vesicles, avoiding the energetically and economically expensive steps required to obtain solid matrixes or pure compounds. The obtained grape bioactive enriched penetration enhancer containing vesicles (PEVs) were multilamellar, around 200nm in size, and more viscous than the corresponding solutions. The antioxidant activity, evaluated by the Folin-Ciocalteu and DPPH assays, was potentiated when the extractive solutions were loaded in PEVs. Further, the grape enriched PEVs were able to ensure an optimal protection against oxidative stress in an ex vivo human erythrocytes-based model.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Manconi M,Marongiu F,Manca ML,Caddeo C,Sarais G,Cencetti C,Pucci L,Longo V,Bacchetta G,Fadda AM

doi

10.1016/j.ijpharm.2017.03.037

subject

Has Abstract

pub_date

2017-05-15 00:00:00

pages

159-166

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(17)30213-2

journal_volume

523

pub_type

杂志文章

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