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Thermoresponsive mesoporous silica nanoparticles as a carrier for skin delivery of quercetin.

Abstract：

:Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising drug delivery systems able to preserve the integrity of the carried substance and/or to selectively reach a target site; however, they have rarely been explored for skin application. In this study, thermoresponsive MSNs, designed to work at physiologic cutaneous temperature, are proposed as innovative topical carriers for quercetin (Q), a well-known antioxidant. The thermosensitive nanoparticles were prepared by functionalizing two different types of matrices, with pore size of 3.5nm (MSNsmall) and 5.0nm (MSNbig), carrying out a free radical copolymerization of N-isopropylacrylamide (NIPAM) and 3-(methacryloxypropyl)trimethoxysilane (MPS) inside the mesopores. The obtained copolymer-grafted MSNs (copoly-MSNs) were physico-chemically characterized and their biocompatibility was attested on a human keratinocyte cell line (HaCaT). The release profiles were assessed and the functional activity of Q, free or loaded, was evaluated in terms of antiradical and metal chelating activities. Ex vivo accumulation and permeation through porcine skin were also investigated. The characterization confirmed the copolymer functionalization of the MSNs. In addition, both the bare and functionalized silica matrices were found to be biocompatible. Among the copolymer-grafted complexes, Q/copoly-MSNbig exhibited more evident thermoresponsive behavior proving the potential of these thermosensitive systems for advanced dermal delivery.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Ugazio E,Gastaldi L,Brunella V,Scalarone D,Jadhav SA,Oliaro-Bosso S,Zonari D,Berlier G,Miletto I,Sapino S

doi

10.1016/j.ijpharm.2016.07.024

subject

Has Abstract

pub_date

2016-09-10 00:00:00

pages

446-454

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(16)30654-8

journal_volume

511

pub_type

杂志文章

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