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Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

Abstract：

:In this report, we investigated the combined effect of drug liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate (ISN) in rat abdominal skin in vitro. Occlusive application of both liposomal and aqueous ISN solution, with and without addition of 5% glycerol, showed that drug liposomalization and addition of glycerol has far-reaching implications for ISN permeation and accumulation in 4 and 8 weeks old rat abdominal skin. Using 8 weeks old rat abdominal skin, the optimal concentration of glycerol to be added to liposomal ISN was found to be 5%. The ISN mean values permeated through and accumulated in stripped 8 weeks old rat abdominal skin from those formulations described above were not significant different, which might indicate the combined effect of glycerol and liposomal ISN resides solely in the stratum corneum (SC). Based on previous reports, the enhancement effect of glycerol might be due to an increase in the SC hydration, and perhaps due to subtle changes in the lipid organization caused by penetration of liposomal lipids within the SC intercellular spaces. These data might provide evidence that glycerol action on SC is useful to facilitate skin permeation and accumulation of drugs formulated in liposome.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Barichello JM,Yamakawa N,Kisyuku M,Handa H,Shibata T,Ishida T,Kiwada H

doi

10.1016/j.ijpharm.2008.01.052

subject

Has Abstract

pub_date

2008-06-05 00:00:00

pages

199-205

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(08)00106-3

journal_volume

357

pub_type

杂志文章

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