Abstract：
:Local anaesthetics may be added to intravenous o/w emulsions of propofol to reduce the initial pain of injection. Due to incompatibility problems of the emulsion on the addition of a local anaesthetic solution, prior encapsulation of the drug within liposomes is suggested. The liposomes were prepared with the sonication method and loaded with either lidocaine hydrochloride (LiHCl) or prilocaine hydrochloride (PrHCl). The liposomal systems were characterised with photon correlation spectroscopy (PCS) in terms of mean particle size and polydispersity. Lamellarity and lamellar thickness were determined by small angle X-ray scattering (SAXS). Visualisation of drug-loaded liposomes was performed with transmission electron microscopy (TEM) after freeze fracture replication of the samples. Depending on the manufacturing procedure mean particle sizes of the drug-free liposomes varied from 150 +/- 9 nm to 102 +/- 2 nm. Drug-loaded liposomes manufactured the same way showed reduced particle sizes of 125 +/- 1 nm and 85 +/- 7 nm, respectively. Determination of bilayer thickness by SAXS yielded 6.2 +/- 0.2 nm in the case of full hydration whereas the bilayer thickness without the hydration shell was just 4.4 +/- 0.2 nm. The small particle sizes achieved are appropriate for intravenous administration.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Müller M,Mackeben S,Müller-Goymann CCdoi
10.1016/j.ijpharm.2004.01.015keywords:
subject
Has Abstractpub_date
2004-04-15 00:00:00pages
139-48issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517304000304journal_volume
274pub_type
杂志文章abstract：:The compaction of powder beds into solid bodies occurs by virtue of the formation of inter-particle bonds. The mechanical strength of the compact depends on the type of bonding interaction, as well as, the inter-particle contact area created in the compression process. A hybrid quasi-continuum computational approach h...
journal_title：International journal of pharmaceutics
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abstract：:This research describes a rapid solubility classification approach that could be used in the discovery and development of new molecular entities. Compounds (N=635) were divided into two groups based on information available in the literature: high solubility (BDDCS/BCS 1/3) and low solubility (BDDCS/BCS 2/4). We estab...
journal_title：International journal of pharmaceutics
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abstract：:The aim of this study was to establish a correlation between carrier characteristics and the dispersibility of drug from the blend. The influence of the roughness of a commonly used carrier material, lactose monohydrate, on the adhesion, dose uniformity, and aerodynamic properties of a model drug, terbutaline sulphate...
journal_title：International journal of pharmaceutics
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abstract：:Aerosolization behavior of carrier-free l-leucine coated salbutamol sulphate inhalable powders has been studied. L-Leucine coatings were formed by physical vapour deposition (PVD) on the surface of the spherical particles in the gas phase. While depositing L-leucine formed pointy crystalline asperities whose size and ...
journal_title：International journal of pharmaceutics
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abstract：:Microemulsions show significant promise for enhancing the oral bioavailability of biopharmaceutics classification system (BCS) class II drugs, but how about class III drugs remains unclear. Here we employed metformin hydrochloride (MET) as the model drug and prepared drug-loaded water-in-oil (W/O) microemulsions selec...
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abstract：:Diatomite makes a promising candidate for a drug carrier because of its high porosity, large surface area, modifiable surface chemistry and biocompatibility. Herein, refined diatomite from Kolubara coal basin, which complied with the pharmacopoeial requirements for heavy metals content and microbiological quality, was...
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journal_title：International journal of pharmaceutics
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abstract：:Cationic liposomes spontaneously interact with negatively charged plasmid DNA to form a transfection competent complex capable of promoting the expression of a therapeutic gene. This work aims to improve the understanding of the poorly defined mechanisms and structural rearrangements associated with the lipid-DNA inte...
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journal_title：International journal of pharmaceutics
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更新日期：2013-11-30 00:00:00
abstract：:Genetic immunization through skin is highly desirable as skin has plenty of antigen presenting cells (APCs) and is easily accessible. The purpose of this study was to investigate the effects of electroporation pulse amplitude, pulse length and number of pulses on cutaneous plasmid DNA vaccine delivery and immune respo...
journal_title：International journal of pharmaceutics
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更新日期：2005-04-27 00:00:00
abstract：:For use in chronic oral chemotherapeutic regimens, the potent anticancer drug docetaxel needs a solid oral dosage form. Because docetaxel has a very low permeability and a very low aqueous solubility (biopharmaceutical classification system class IV), a pharmacokinetic booster was combined with a newly developed solid...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章,随机对照试验
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更新日期：2011-11-28 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2015-11-10 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2008.09.014
更新日期：2009-02-09 00:00:00
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更新日期：2017-03-15 00:00:00
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更新日期：2016-09-25 00:00:00
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abstract：:Infection still present as one of common complications after total hip replacement (∼2.5%), which may cause serious outcomes. For preventing such risk, loading antibiotics onto implants for increasing local drug concentration at targeted sites could be a solution. This study aims at modifying the surface of hydroxyapa...
journal_title：International journal of pharmaceutics
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更新日期：2014-12-30 00:00:00
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journal_title：International journal of pharmaceutics
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abstract：:The pharmacokinetics of NS-49, a newly developed phenethylamine class alpha(1A)-adrenoceptor agonist, was investigated in rats, rabbits, and dogs given intravenous and oral doses that have little effect on the renal blood flow rate (approximating the range of clinical doses). A three-compartment open model adequately ...
journal_title：International journal of pharmaceutics
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abstract：:Amphipathic partial dendrimers having three lipidic (C(14)) chains coupled to dendritic lysine head groups with eight, 16 or 32 free terminal amino groups have been synthesised by solid-phase peptide synthesis. Liposomes were prepared with positive, negative and neutral charge using the dehydration-rehydration method ...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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abstract：:A sensitive atmospheric pressure chemical ionization liquid chromatographic-mass spectrometric (APCI-LC-MS) assay with positive ion mode has been developed for the determination of nifedipine in human plasma. In this method, nifedipine was extracted from human plasma using diethyl ether with dimethoxanate as the inter...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章,随机对照试验
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更新日期：2007-08-16 00:00:00
