Abstract：
:The effect of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was investigated. The elastic properties of five pharmaceutical products were characterized by their total elastic recovery. To test the interfacial strength of the bilayer tablets a new flexural test was proposed. Thanks to the test configuration, the experimental breaking force is directly correlated with the interfacial layer strength. Depending on the materials, the fracture occurred over the interface or in one of the two layers. In most cases, the highest breaking forces were obtained when the materials had close elastic recovery. On the contrary, for materials with different elastic recovery, the breaking forces were reduced. The observed changes in the interfacial mechanical strength were statistically analyzed. Such an approach has an importance in the growing interest in the Quality by Design (QbD) concept in pharmaceutical industry.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Busignies V,Mazel V,Diarra H,Tchoreloff Pdoi
10.1016/j.ijpharm.2013.09.009subject
Has Abstractpub_date
2013-11-30 00:00:00pages
260-7issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(13)00844-2journal_volume
457pub_type
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