当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery.

Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery.

Abstract：

:The combined approach of cyclodextrin complexation and entrapment in liposomes was investigated in order to develop an effective topical formulation of ketoprofen. Equimolar complex of drug and hydroxypropyl-beta-cyclodextrin (HPbetaCyd) was added at different concentrations to the aqueous phase of liposomes consisting of phosphatidylcholine and cholesterol (60%/40%, w/w). Liposomes were prepared with different techniques, such as thin layer evaporation, freezing and thawing, extrusion through microporous membrane, and reverse phase evaporation method, obtaining, respectively, multi-lamellar vesicles (MLV), frozen and thawed MLV (FATMLV), small uni-lamellar vesicles (SUV) and large uni-lamellar vesicles (LUV). Size and morphology of the different types of liposomes were investigated by light scattering analysis, transmission electron microscopy, and confocal laser scanning microscopy, whereas drug entrapment efficiency was determined by dialysis experiments. Cyclodextrin complexation improved drug solubilization and allowed a strong improvement of its entrapment into the aqueous liposomal phase. Liposome preparation method and operating conditions clearly affected both liposome size and drug loading capacity. Encapsulation efficiency increased with increasing the complex concentration up to 10 mM, and was in the order MLV>LUV>SUV. An opposite behaviour was observed for FATMLV, probably due to the freezing phase required by such a preparation method, which reduced the complex solubility. Moreover, it was not possible to use higher complex concentrations, due to the destabilizing effect of cyclodextrins toward the liposomal membrane. Permeability studies of drug-HPbetaCyd complexes, directly in solution or incorporated in liposomes, performed across artificial membranes simulating the skin behaviour, highlighted, as expected, a prolonged release effect of liposomal formulations. Furthermore, the drug permeation rate depended on the vesicle characteristics and varied in the order: SUV>MLV=FATMLV>LUV. Therefore, the most suitable liposome preparation method can be suitably selected on the basis of drug encapsulation efficiency and/or desired drug release rate.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Maestrelli F,González-Rodríguez ML,Rabasco AM,Mura P

doi

10.1016/j.ijpharm.2005.12.047

keywords:

subject

Has Abstract

pub_date

2006-04-07 00:00:00

pages

53-60

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(06)00012-3

journal_volume

312

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model.

    abstract：:Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the perf...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.04.023

    authors： Frant M,Dayyoub E,Bakowsky U,Liefeith K

    更新日期：2018-07-30 00:00:00

  • Saturated fatty acids and fatty acid esters promote the polymorphic transition of clarithromycin metastable form I crystal.

    abstract：:The phase transition of active pharmaceutical ingredients should be taken into account during manufacturing, processing- and storage, because different crystal forms lead to different physical properties of formulations. The phase transition of clarithromycin (CAM) metastable form I to stable form II was investigated ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.08.041

    authors： Watanabe M,Mizoguchi M,Aoki H,Iwao Y,Noguchi S,Itai S

    更新日期：2016-10-15 00:00:00

  • Non-viral dried powders for respiratory gene delivery prepared by cationic and chitosan loaded liposomes.

    abstract：:The aim of this work was to investigate lipid-based dried powders as transfection competent carriers capable of promoting the expression of therapeutic genes. The lipid-based vectors were prepared by combining different cationic lipids 1,2-dioleoyl-3-trimethylammoniumpropane chloride (DOTAP), 1,2-dioleoyl-sn-glycero-3...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.07.034

    authors： Colonna C,Conti B,Genta I,Alpar OH

    更新日期：2008-11-19 00:00:00

  • Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture.

    abstract：:The purpose of this study was to investigate the formation mechanism of colloidal nanoparticles after dispersion of probucol/polyvinylpyrrolidone (PVP)/sodium dodecyl sulphate (SDS) ternary ground mixture (GM) into water. Probucol, PVP and SDS were mixed at a weight ratio of 1:3:1 and ground for 30 min with a vibratio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.10.052

    authors： Pongpeerapat A,Wanawongthai C,Tozuka Y,Moribe K,Yamamoto K

    更新日期：2008-03-20 00:00:00

  • Stabilisation and determination of the biological activity of L-asparaginase in poly(D,L-lactide-co-glycolide) nanospheres.

    abstract：:The preservation of biological activity of protein drugs in formulations is still a major challenge for successful drug delivery. The enzyme L-asparaginase, which exhibits a short in vivo half-life and is only active against leukaemia in its tetrameric form, was encapsulated in poly(D,L-lactide-co-glycolide) nanospher...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00071-1

    authors： Wolf M,Wirth M,Pittner F,Gabor F

    更新日期：2003-04-30 00:00:00

  • smartPearls - Novel physically stable amorphous delivery system for poorly soluble dermal actives.

    abstract：:Dermally applied poorly soluble actives whether in cosmetics or pharmaceuticals show insufficient skin penetration. Especially actives being insoluble in both phases of dermal vehicles, i.e. water and oil have no or less real effect. An approach to overcome this obstacle is the use of amorphous actives instead of the ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2018.11.018

    authors： Müller RH,Hespeler D,Jin N,Pyo SM

    更新日期：2019-01-30 00:00:00

  • Improvement of antischistosomal activity of praziquantel by incorporation into phosphatidylcholine-containing liposomes.

    abstract：:Praziquantel (PZQ) is effective against all known species of Schistosomes that infect humans. The failure of mass treatment of schistosomiasis has been attributed to the fact that therapy is not sufficiently long-lasting. This effect may be due to the low bioavailability of PZQ that has a low hydrosolubility and fast ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.02.009

    authors： Mourão SC,Costa PI,Salgado HR,Gremião MP

    更新日期：2005-05-13 00:00:00

  • Nanoparticle-based delivery of carbamazepine: A promising approach for the treatment of refractory epilepsy.

    abstract：:Resistance to antiepileptic drugs (AEDs) is a major clinical problem. The overexpression of P-glycoprotein (Pgp), one of the main transporters limiting the entry of xenobiotics into the brain, is among the factors contributing to the AED resistance. Presently, there is no consensus on the interaction of carbamazepine ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.05.023

    authors： Zybina A,Anshakova A,Malinovskaya J,Melnikov P,Baklaushev V,Chekhonin V,Maksimenko O,Titov S,Balabanyan V,Kreuter J,Gelperina S,Abbasova K

    更新日期：2018-08-25 00:00:00

  • Granule size control and targeting in pulsed spray fluid bed granulation.

    abstract：:The primary aim of the study was to investigate the effects of pulsed liquid feed on granule size. The secondary aim was to increase knowledge of this technique in granule size targeting. Pulsed liquid feed refers to the pump changing between on- and off-positions in sequences, called duty cycles. One duty cycle consi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.041

    authors： Ehlers H,Liu A,Räikkönen H,Hatara J,Antikainen O,Airaksinen S,Heinämäki J,Lou H,Yliruusi J

    更新日期：2009-07-30 00:00:00

  • Surface-dependent endocytosis of poly(isobutylcyanoacrylate) nanoparticles by Trichomonas vaginalis.

    abstract：:Previous data from our research group showed that chitosan-coated poly(isobutylcyanoacrylate) nanoparticles (NPs) (denoted PIBCA/Chito20) exhibited intrinsic anti-Trichomonas vaginalis activity, while PIBCA/pluronic® F68 without chitosan (PIBCA/F68) were inactive. However, the mechanism of anti-T. vaginalis activity o...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.07.006

    authors： Malli S,Bories C,Bourge M,Loiseau PM,Bouchemal K

    更新日期：2018-09-05 00:00:00

  • Poloxamer-based solid dispersions for oral delivery of docetaxel: Differential effects of F68 and P85 on oral docetaxel bioavailability.

    abstract：:Development of an oral docetaxel formulation has been hindered mainly due to its poor solubility and oral bioavailability. The aim of this study was to develop poloxamer F68/P85-based solid dispersions (SDs) for the oral delivery of docetaxel and investigate their in vivo pharmacokinetic impacts on the systemic absorp...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.002

    authors： Song CK,Yoon IS,Kim DD

    更新日期：2016-06-30 00:00:00

  • Thermosensitivity and release from poly N-isopropylacrylamide-polylactide copolymers.

    abstract：:A series of thermoresponsive-co-biodegradable polymers, containing varying molar ratios of N-isopropylacrylamide (NIPA) and poly-lactic acid diacrylate macromer (PLAM) were prepared and characterised. Chemical structures were confirmed by nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR). The hydr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.036

    authors： Chearúil FN,Corrigan OI

    更新日期：2009-01-21 00:00:00

  • Quaternary polymethacrylate-magnesium aluminum silicate films: molecular interactions, mechanical properties and tackiness.

    abstract：:The aim of this study was to investigate the impact of the addition of magnesium aluminum silicate (MAS), a natural clay, on the properties of polymeric films based on quaternary polymethacrylates (QPMs). Two commercially available aqueous QPM dispersions were studied: Eudragit(®) RS 30D and Eudragit(®) RL 30D (the dr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.10.016

    authors： Rongthong T,Sungthongjeen S,Siepmann J,Pongjanyakul T

    更新日期：2013-12-15 00:00:00

  • Solid-state compatibility studies using a high-throughput and automated forced degradation system.

    abstract：:As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is capable of handling more compounds in shorter times. In this paper, the establishment of a high-throughput automated powder compatibility testing system is reported. The integrated robotic system automatica...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.002

    authors： Wakasawa T,Sano K,Hirakura Y,Toyo'oka T,Kitamura S

    更新日期：2008-05-01 00:00:00

  • Structure-activity relationship of coordinated catecholamine in the [Ru(III)(NH3)4(catecholamine)]+ complex.

    abstract：:The redox chemistry and pharmacological studies of the novel blue ruthenium(III)-catecholamine complexes were investigated in aqueous medium and compared to the free catecholamines. The [Ru(III)(NH3)4(catecholamine)]+ can be oxidized or reduced reversibly in one electron redox couples in aqueous solution. This is in c...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.10.018

    authors： de Lima RG,Marchesi MS,de Godoy MA,Cassano AO,de Oliveira AM,da Silva RS

    更新日期：2004-03-01 00:00:00

  • In-line quantification of two active ingredients in a batch blending process by near-infrared spectroscopy: influence of physical presentation of the sample.

    abstract：:The aim of this study was to apply near-infrared (NIR) spectroscopy to the simultaneous in-line monitoring of two active pharmaceutical ingredients (APIs) in a pharmaceutical batch blending process. The formulation under study consisted of a high load API (A1), one polymer, a second API (A2) and one lubricant. Additio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.04.078

    authors： Martínez L,Peinado A,Liesum L

    更新日期：2013-07-15 00:00:00

  • Role of the elasticity of pharmaceutical materials on the interfacial mechanical strength of bilayer tablets.

    abstract：:The effect of the elasticity of various pharmaceutical materials on the interfacial adhesion in bilayer tablets was investigated. The elastic properties of five pharmaceutical products were characterized by their total elastic recovery. To test the interfacial strength of the bilayer tablets a new flexural test was pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.09.009

    authors： Busignies V,Mazel V,Diarra H,Tchoreloff P

    更新日期：2013-11-30 00:00:00

  • Microagglomeration of pulverized pharmaceutical powders using the Wurster process I. Preparation of highly drug-incorporated, subsieve-sized core particles for subsequent microencapsulation by film-coating.

    abstract：:A novel agglomeration process of pulverized pharmaceutical powders into subsieve-sized agglomerates (microagglomeration) was designed for manufacturing highly drug-incorporated core particles for subsequent microencapsulation by film-coating. The microagglomeration of pulverized phenacetin powder, whose mass median di...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00006-x

    authors： Ichikawa H,Fukumori Y

    更新日期：1999-04-15 00:00:00

  • Effect of aqueous solubility of grafted moiety on the physicochemical properties of poly(d,l-lactide) (PLA) based nanoparticles.

    abstract：:In order to evaluate the solubility effect of grafted moiety on the physicochemical properties of poly(d,l-lactide) (PLA) based nanoparticles (NPs), two materials of completely different aqueous solubility, polyethylene glycol (PEG) and palmitic acid were grafted on PLA backbone at nearly the same grafting density, 2....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.12.059

    authors： Essa S,Rabanel JM,Hildgen P

    更新日期：2010-03-30 00:00:00

  • Vesicles as antibiotic carrier: State of art.

    abstract：:Antimicrobial resistance (AMR) has become a global health problem. Bacteria are able to adapt to different environments, with the presence or absence of a host, forming colonies and biofilms. In fact, biofilm formation confers chemical protection to the microbial cells, thus making most of the conventional antibiotics...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2020.119478

    authors： Marchianò V,Matos M,Serrano-Pertierra E,Gutiérrez G,Blanco-López MC

    更新日期：2020-07-30 00:00:00

  • Development of co-solvent freeze-drying method for the encapsulation of water-insoluble thiostrepton in sterically stabilized micelles.

    abstract：:The purpose of this work was to develop a practical and scalable method to encapsulate the hydrophobic antibiotic thiostrepton (TST) in sterically stabilized micelles (SSM). Using the conventional method of thin-film hydration, we encapsulated up to 5 drug molecules per SSM (diameter ∼ 16 nm). However, since this meth...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.12.001

    authors： Esparza K,Onyuksel H

    更新日期：2019-02-10 00:00:00

  • Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer.

    abstract：:The effect of various surfactants (sodium cholate, sodium taurocholate, Tween 80 and Poloxamer F68) on enhancing the transepithelial permeability of fexofenadine.HCl was evaluated in a human nasal epithelial cell monolayer model. The cytotoxicity of the surfactants on the human nasal epithelial cells was evaluated by ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.043

    authors： Lin H,Gebhardt M,Bian S,Kwon KA,Shim CK,Chung SJ,Kim DD

    更新日期：2007-02-07 00:00:00

  • A liposomal delivery system that targets liver endothelial cells based on a new peptide motif present in the ApoB-100 sequence.

    abstract：:Liver dysfunction is associated with a variety of liver diseases, including viral or alcoholic hepatitis, fibrosis, cirrhosis, and portal hypertension. A targeted drug delivery system would be very useful in the treatment of these diseases. We herein describe the development of a system comprised of a new peptide-lipi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.07.068

    authors： Akhter A,Hayashi Y,Sakurai Y,Ohga N,Hida K,Harashima H

    更新日期：2013-11-01 00:00:00

  • Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: development, characterization and interaction with leuprolide.

    abstract：:Polysaccharide-coated liposomes have been studied for their potential use for peptide drug delivery by the oral route because they are able to minimize the disruptive influences on peptide drugs of gastrointestinal fluids. The aim of this work was to synthesize and characterize a modified polysaccharide, O-palmitoylsc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.06.040

    authors： Carafa M,Marianecci C,Annibaldi V,Di Stefano A,Sozio P,Santucci E

    更新日期：2006-11-15 00:00:00

  • Characterisation of recombinant factor IX before and after GlycoPEGylation.

    abstract：:The effect of the GlycoPEGylation process used for prolonging the half-life of recombinant factor IX (rFIX) has no impact on the primary and higher order structure of activated factor IX. Characterisation work performed on recombinant factor IX and on the GlycoPEGylated form of rFIX (N9-GP), confirm that the primary s...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119654

    authors： Nielsen FS,Schmidt AS,Kristensen AK,Nielsen AD,Kristensen BK,Palm L

    更新日期：2020-10-15 00:00:00

  • Preparation of surface modified protein nanoparticles by introduction of sulfhydryl groups.

    abstract：:The objective of the present study was to establish several methods for the introduction of thiol groups onto the surface of human serum albumin (HSA) nanoparticles. Besides the epsilon-amino groups of lysine, the carboxyl groups of asparaginic and glutaminic acid, and the carbonyl groups of the cross-linker glutarald...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00590-1

    authors： Weber C,Reiss S,Langer K

    更新日期：2000-12-15 00:00:00

  • Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions.

    abstract：:An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.11.035

    authors： McCarron PA,Donnelly RF,Zawislak A,Woolfson AD,Price JH,McClelland R

    更新日期：2005-04-11 00:00:00

  • Development of a cyclodextrin-based aqueous cyclosporin A eye drop formulations.

    abstract：:Cyclosporin A (CyA) is a lipophilic, cyclic polypeptide drug with anti-inflammatory properties. It is used in topical treatment of dry eyes and is now commercially available in oil based surfactant containing eye drops. Surfactants can irritate the eye surface causing burning, itching and irritation of the conjunctiva...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.040

    authors： Jóhannsdóttir S,Jansook P,Stefánsson E,Loftsson T

    更新日期：2015-09-30 00:00:00

  • Protein-loaded PLGA microparticles engineered by flow focusing: physicochemical characterization and protein detection by reversed-phase HPLC.

    abstract：:In the present study, a novel synthesis technique based on the flow focusing (FF) technology is investigated for the preparation of green fluorescent protein (GFP)-loaded poly(D,L-lactide-co-glycolide) (PLGA) microparticles. To our knowledge, this novel technique has never been applied to the formulation of proteins i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.07.017

    authors： Holgado MA,Cózar-Bernal MJ,Salas S,Arias JL,Alvarez-Fuentes J,Fernández-Arévalo M

    更新日期：2009-10-01 00:00:00

  • Spherical agglomerates of lactose with enhanced mechanical properties.

    abstract：:The aim of this study was to prepare spherical agglomerates of lactose and to evaluate their physicochemical properties, flow properties, particle friability and compaction properties, and to compare them to commercially available types of lactose for direct compression (spray-dried, granulated and anhydrous β-lactose...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.11.040

    authors： Lamešić D,Planinšek O,Lavrič Z,Ilić I

    更新日期：2017-01-10 00:00:00