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Evaluation of a water-soluble bioadhesive patch for photodynamic therapy of vulval lesions.

Abstract：

:An innovative bioadhesive patch intended primarily as a vulval drug delivery system and, specifically, as a means to deliver photosensitisers, or their prodrugs, for photodynamic purposes is described. The patch was formulated with a copolymer of methyl vinyl ether and maleic anhydride (PMVE/MA) as a bioadhesive matrix and poly(vinyl chloride) as a drug-impervious backing layer. Adhesive strength to neonate porcine skin, as a model substrate, was evaluated using peel and tensile testing measurements. Acceptabilities of non-drug loaded patches were appraised using human volunteers and visual-analogue scoring devices. An optimal formulation, with water uptake and peel strengths appropriate for vulval drug delivery, was cast from a 20% (w/w) PMVE/MA solution and adhered with a strength of approximately 1.7 Ncm(-2). Patient evaluation demonstrated comfort and firm attachment for up to 4h in mobile patients. Aminolevulinic acid, a commonly used photosensitiser, was formulated into the candidate formulation and applied to vulval intraepithelial neoplastic lesions. Fluorescence under ultraviolet illumination revealed protoporphyrin synthesis. The patch achieves the extended application times obligatory in topical photodynamic therapy of vulval lesions, thereby contributing to potential methods for the eradication of neoplastic lesions in the lower female reproductive tract.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

McCarron PA,Donnelly RF,Zawislak A,Woolfson AD,Price JH,McClelland R

doi

10.1016/j.ijpharm.2004.11.035

keywords:

subject

Has Abstract

pub_date

2005-04-11 00:00:00

pages

11-23

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(04)00729-X

journal_volume

293

pub_type

杂志文章

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