A novel treatment strategy for preterm birth: Intra-vaginal progesterone-loaded fibrous patches.

Abstract:

:Progesterone-loaded poly(lactic) acid fibrous polymeric patches were produced using electrospinning and pressurized gyration for intra-vaginal application to prevent preterm birth. The patches were intravaginally inserted into rats in the final week of their pregnancy, equivalent to the third trimester of human pregnancy. Maintenance tocolysis with progesterone-loaded patches was elucidated by recording the contractile response of uterine smooth muscle to noradrenaline in pregnant rats. Both progesterone-loaded patches indicated similar results from release and thermal studies, however, patches obtained by electrospinning had smaller average diameters and more uniform dispersion compared to pressurized gyration. Patches obtained by pressurized gyration had better results in production yield and tensile strength than electrospinning; thereby pressurized gyration is better suited for scaled-up production. The patches did not affect cell attachment, viability, and proliferation on Vero cells negatively. Consequently, progesterone-loaded patches are a novel and successful treatment strategy for preventing preterm birth.

journal_name

Int J Pharm

authors

Cam ME,Hazar-Yavuz AN,Cesur S,Ozkan O,Alenezi H,Turkoglu Sasmazel H,Sayip Eroglu M,Brako F,Ahmed J,Kabasakal L,Ren G,Gunduz O,Edirisinghe M

doi

10.1016/j.ijpharm.2020.119782

subject

Has Abstract

pub_date

2020-10-15 00:00:00

pages

119782

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)30766-3

journal_volume

588

pub_type

杂志文章
  • In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS.

    abstract::The novel anticancer agent BIBX1382BS is a representative of the human epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. BIBX1382BS, for parenteral use, is formulated pharmaceutically as a lyophilized product containing 100 mg BIBX1382BS per dosage unit. This in vitro study was performed to establish...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(99)00389-0

    authors: Nuijen B,Bouma M,Henrar RE,Brauns U,Bette P,Bult A,Beijnen JH

    更新日期:2000-01-25 00:00:00

  • Ultra-deformable liposomes containing bleomycin: in vitro stability and toxicity on human cutaneous keratinocyte cell lines.

    abstract::Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2005.04.019

    authors: Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

    更新日期:2005-08-26 00:00:00

  • Compressed xanthan and karaya gum matrices: hydration, erosion and drug release mechanisms.

    abstract::Directly compressed matrices were produced containing either xanthan gum or karaya gum as a release-controlling agent. These swellable hydrophilic natural gums were used to control the release of varying proportions of two model drugs, caffeine and diclofenac sodium, which have different solubilities in aqueous medium...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(00)00444-0

    authors: Munday DL,Cox PJ

    更新日期:2000-08-10 00:00:00

  • Transferosomes as nanocarriers for drugs across the skin: Quality by design from lab to industrial scale.

    abstract::Transferosomes, also known as transfersomes, are ultradeformable vesicles for transdermal applications consisting of a lipid bilayer with phospholipids and an edge activator and an ethanol/aqueous core. Depending on the lipophilicity of the active substance, it can be encapsulated within the core or amongst the lipid ...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpharm.2019.118817

    authors: Fernández-García R,Lalatsa A,Statts L,Bolás-Fernández F,Ballesteros MP,Serrano DR

    更新日期:2020-01-05 00:00:00

  • Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: in vitro and in vivo evaluation in healthy volunteers.

    abstract::Phenoporlamine hydrochloride is a novel compound that is used for the treatment of hypertension. The purpose of this study was to develop a sustained release tablet for phenoporlamine hydrochloride because of its short biological half-life. Three floating matrix formulations of phenoporlamine hydrochloride based on ga...

    journal_title:International journal of pharmaceutics

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.ijpharm.2005.12.003

    authors: Xu X,Sun M,Zhi F,Hu Y

    更新日期:2006-03-09 00:00:00

  • Structure elucidation and formation mechanistic study of a methylene-bridged pregabalin dimeric degradant in pregabalin extended-release tablets.

    abstract::During the pharmaceutical development of pregabalin extended-release tablets, an unknown degradant at a relative retention time (RRT) of 11.7 was observed and its nominal amount exceeded the ICH identification threshold in an accelerated stability study. The aim of this study is to identify the structure and investiga...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.118910

    authors: Tian Y,Lin J,Chen F,Wang S,Li D,Kuang Z,Zhu W,Li Y,Zheng T,Cao W,Zhu B,Tsai E,Fu L,Li M

    更新日期:2020-02-15 00:00:00

  • Molecular expression and functional activity of sodium dependent multivitamin transporter in human prostate cancer cells.

    abstract::Nutrient transporters expressed on cell membrane have been targeted for enhancing bioavailability of poorly permeable drugs. Sodium dependent multivitamin transporter (SMVT) is once such carrier system, utilized for improving drug targeting to specific tissues. Therefore, the main objective of this study is to charact...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.06.011

    authors: Patel M,Vadlapatla RK,Shah S,Mitra AK

    更新日期:2012-10-15 00:00:00

  • Delivery of drugs to intracellular organelles using drug delivery systems: Analysis of research trends and targeting efficiencies.

    abstract::Targeting of drug delivery systems (DDSs) to specific intracellular organelles (i.e., subcellular targeting) has been investigated in numerous publications, but targeting efficiency of these systems is seldom reported. We searched scientific publications in the subcellular DDS targeting field and analyzed targeting ef...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpharm.2015.10.053

    authors: Maity AR,Stepensky D

    更新日期:2015-12-30 00:00:00

  • Type of pH sensitive linker reveals different time-dependent intracellular localization, in vitro and in vivo efficiency in alpha-fetoprotein receptor targeted doxorubicin conjugate.

    abstract::Despite the presence of a variety of modern anticancer drugs at the market, doxorubicin (Dox) is still widely used in antineoplastic therapy, although its administration causes severe side effects. To enhance specific activity of such molecules, various approaches have been exploited: targeted moieties like monoclonal...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2018.12.073

    authors: Mollaev M,Gorokhovets N,Nikolskaya E,Faustova M,Zabolotsky A,Zhunina O,Sokol M,Zamulaeva I,Severin E,Yabbarov N

    更新日期:2019-03-25 00:00:00

  • Comparative study of liposomes, ethosomes and transfersomes as carriers for enhancing the transdermal delivery of diflunisal: In vitro and in vivo evaluation.

    abstract::The current study aimed to develop an effective transdermal nanovesicular carrier of diflunisal that provides enhanced delivery through the skin. Two types of nanovesicles, ethosomes and transfersomes, were investigated and compared to conventional liposomes. Ethosomes with variable ethanol contents (10, 30 and 50%) a...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.04.001

    authors: Abd El-Alim SH,Kassem AA,Basha M,Salama A

    更新日期:2019-05-30 00:00:00

  • Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.

    abstract::A drug carrier of colloidal lipid particles with improved payloads and enhanced storage stability was investigated. Based on the experiences with hard fats nanoparticles, a new type of solid lipid nanoparticles (SLN) has been developed by incorporating triglyceride containing oils in the solid core of said particle. T...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(00)00378-1

    authors: Jenning V,Thünemann AF,Gohla SH

    更新日期:2000-04-20 00:00:00

  • Cationic solid lipid nanoparticles enhance ocular hypotensive effect of melatonin in rabbit.

    abstract::The study was aimed at evaluating whether the ocular hypotensive effect of melatonin (MEL) was enhanced by its encapsulation in cationic solid lipid nanoparticles (cSLN), as well as at determining the tolerability of these formulations on the ocular surface. MEL was loaded in cSLN that had already been shown to be sui...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2014.11.032

    authors: Leonardi A,Bucolo C,Drago F,Salomone S,Pignatello R

    更新日期:2015-01-15 00:00:00

  • Efficient gene delivery to primary human retinal pigment epithelial cells: The innate and acquired properties of vectors.

    abstract::The purpose of this study is designing non-viral gene delivery vectors for transfection of the primary human retinal pigment epithelial cells (RPE). In the design process of gene delivery vectors, considering physicochemical properties of vectors alone does not seem to be enough since they interact with constituents o...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2016.12.048

    authors: Tasharrofi N,Kouhkan F,Soleimani M,Soheili ZS,Atyabi F,Akbari Javar H,Abedin Dorkoosh F

    更新日期:2017-02-25 00:00:00

  • Nanosuspensions for the formulation of aphidicolin to improve drug targeting effects against leishmania infected macrophages.

    abstract::A series of labdans and their derivatives have been identified as novel potential antileishmanial drugs using an in vitro test system against extracellular promastigotes and intracellular amastigotes of Leishmania donovani in murine macrophages (Kayser, O., Kiderlen, A.F., 1998. In vitro activity of leishmanicidal lab...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(99)00434-2

    authors: Kayser O

    更新日期:2000-03-10 00:00:00

  • Determination of bisphenol A in water and the medical devices used in hemodialysis treatment.

    abstract::Bisphenol A (BPA) is an endocrine disruptor found in food containers and plastic beverages and also in medical devices such as dialyzers. The aim of this study is while taking into account the BPA originating in medical devices and the water used in dialysate production, to provide the first published investigation of...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2016.03.003

    authors: Bacle A,Thevenot S,Grignon C,Belmouaz M,Bauwens M,Teychene B,Venisse N,Migeot V,Dupuis A

    更新日期:2016-05-30 00:00:00

  • Experimental and computational study of the effect of breath-actuated mechanism built in the NEXThaler® dry powder inhaler.

    abstract::The breath-actuated mechanism (BAM) is a mechanical unit included in NEXThaler® with the role of delaying the emission of the drug until the inhalation flow rate of the patient is sufficiently high to detach the drug particles from their carriers. The main objective of this work was to analyse the effect of the presen...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2017.09.057

    authors: Farkas Á,Lewis D,Church T,Tweedie A,Mason F,Haddrell AE,Reid JP,Horváth A,Balásházy I

    更新日期:2017-11-25 00:00:00

  • Photodynamic ultradeformable liposomes: Design and characterization.

    abstract::Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2006.11.015

    authors: Montanari J,Perez AP,Di Salvo F,Diz V,Barnadas R,Dicelio L,Doctorovich F,Morilla MJ,Romero EL

    更新日期:2007-02-07 00:00:00

  • Formation, characterization and pH dependence of rifampicin: heptakis(2,6-di-O-methyl)-β-cyclodextrin complexes.

    abstract::Rifampicin (Rif) is a broad spectrum antibiotic used as a first line agent in the treatment of mycobacterial infections. However, its low solubility and reduced stability in water limit its bioavailability, thus requiring the use of complex formulations. Here, we present a systematic study of Rif in complex with a met...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2017.06.015

    authors: Angiolini L,Agnes M,Cohen B,Yannakopoulou K,Douhal A

    更新日期:2017-10-15 00:00:00

  • Investigation of the parameters used in fused deposition modeling of poly(lactic acid) to optimize 3D printing sessions.

    abstract::This study assesses the feasibility of printing implantable devices using 3D printing Fused deposition modeling (FDM) technology. The influence of the deposition temperature, the deposition rate and the layer thickness on the printing process and the physical properties of the devices were evaluated. The filaments wer...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.05.008

    authors: Carlier E,Marquette S,Peerboom C,Denis L,Benali S,Raquez JM,Amighi K,Goole J

    更新日期:2019-06-30 00:00:00

  • Combined effect of liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate in rat skin.

    abstract::In this report, we investigated the combined effect of drug liposomalization and addition of glycerol on the transdermal delivery of isosorbide 5-nitrate (ISN) in rat abdominal skin in vitro. Occlusive application of both liposomal and aqueous ISN solution, with and without addition of 5% glycerol, showed that drug li...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2008.01.052

    authors: Barichello JM,Yamakawa N,Kisyuku M,Handa H,Shibata T,Ishida T,Kiwada H

    更新日期:2008-06-05 00:00:00

  • Simultaneous determination of amiloride and furosemide in pharmaceutical formulations by first digital derivative spectrophotometry.

    abstract::This work presents a simple and fast method for the simultaneous determination of amiloride and furosemide by digital derivative spectrophotometry. HCl 1 x 10(-2) mol/l dissolved in ethanol was used as solvent and to extract drugs from formulations. Subsequently the samples were evaluated directly by first digital der...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(02)00482-9

    authors: Inés Toral M,Pope S,Quintanilla S,Richter P

    更新日期:2002-12-05 00:00:00

  • Developability assessment of clinical drug products with maximum absorbable doses.

    abstract::Maximum absorbable dose refers to the maximum amount of an orally administered drug that can be absorbed in the gastrointestinal tract. Maximum absorbable dose, or D(abs), has proved to be an important parameter for quantifying the absorption potential of drug candidates. The purpose of this work is to validate the us...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.02.003

    authors: Ding X,Rose JP,Van Gelder J

    更新日期:2012-05-10 00:00:00

  • Synthesis and evaluation of styrene-maleic acid copolymer conjugated amphotericin B.

    abstract::Amphotericin B (AmB), which plays a central role in the treatment of systemic fungal infections, is difficult to formulate because it's sparingly soluble in water and organic solvents. We previously prepared AmB-loaded micelles using styrene-maleic acid copolymer (SMA). Although solubilization was achieved by this for...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2019.118719

    authors: Banshoya K,Kaneo Y,Tanaka T,Yamamoto S,Maeda H

    更新日期:2019-12-15 00:00:00

  • A high throughput platform for understanding the influence of excipients on physical and chemical stability.

    abstract::The present study puts forward a miniaturized high-throughput platform to understand influence of excipient selection and processing on the stability of a given drug compound. Four model drugs (sodium naproxen, theophylline, amlodipine besylate and nitrofurantoin) and ten different excipients were selected. Binary phy...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.08.025

    authors: Raijada D,Cornett C,Rantanen J

    更新日期:2013-08-30 00:00:00

  • Colloidal particles containing labeling agents and cyclodextrins for theranostic applications.

    abstract::This review aims to give to the reader some new light on cyclodextrin (CD)-based theranostic agents in order to complete our recently published review dedicated to CD-particles conjugates in drug delivery systems (Zafar et al., 2014). CDs are biocompatible sugar-based macrocycles used in a wide range of biomedical app...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章,评审

    doi:10.1016/j.ijpharm.2014.06.004

    authors: Zafar N,Fessi H,Elaissari A

    更新日期:2014-09-10 00:00:00

  • Multifunctional nanogels with dual temperature and pH responsiveness.

    abstract::Over the last 10 years, the development of intelligent biomaterials for medical and pharmaceutical applications has attracted growing interest by combining interdisciplinary efforts. Between them nanogels represent one of the most attractive carriers for innovative drug delivery systems. In the present investigation n...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2016.10.017

    authors: Nita LE,Chiriac AP,Diaconu A,Tudorachi N,Mititelu-Tartau L

    更新日期:2016-12-30 00:00:00

  • Effective melanoma cancer suppression by iontophoretic co-delivery of STAT3 siRNA and imatinib using gold nanoparticles.

    abstract::Co-delivery of chemotherapeutic agents improve anti-tumor efficacy and reduce cancer resistance. Here, we report development of layer-by-layer assembled gold nanoparticles (LbL-AuNP) containing anti-STAT3 siRNA and imatinib mesylate (IM) to treat melanoma. The combination treatment with STAT3 siRNA and IM in B16F10 me...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2017.03.087

    authors: Labala S,Jose A,Chawla SR,Khan MS,Bhatnagar S,Kulkarni OP,Venuganti VVK

    更新日期:2017-06-20 00:00:00

  • Ultrasonic real-time in-die monitoring of the tablet compaction process-a proof of concept study.

    abstract::The mechanical properties of a drug tablet can affect its performance (e.g., dissolution profile and its physical robustness. An ultrasonic system for real-time in-die tablet mechanical property monitoring during compaction has been demonstrated. The reported set-up is a proof of concept compaction monitoring system w...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2012.09.014

    authors: Stephens JD,Kowalczyk BR,Hancock BC,Kaul G,Cetinkaya C

    更新日期:2013-02-14 00:00:00

  • Direct quantification of unencapsulated doxorubicin in liposomal doxorubicin formulations using capillary electrophoresis.

    abstract::To understand the quality, efficacy, and safety of liposomal drugs, it is necessary to develop a robust and accurate method for the separation and the quantification of unencapsulated and liposome-associated drugs (or liposomal encapsulated drugs). Conventional methods involve separation of unencapsulated and liposome...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/j.ijpharm.2018.07.019

    authors: Ansar SM,Jiang W,Mudalige T

    更新日期:2018-10-05 00:00:00

  • Dehydration behavior of nedocromil magnesium pentahydrate.

    abstract::The dehydration of nedocromil magnesium (NM) pentahydrate proceeds in two steps, corresponding to the loss of four water molecules in the first step and one water molecule in the second step. The effects of temperature, particle size, sample weight, water vapor pressure and dehydration-rehydration cycle on both the ki...

    journal_title:International journal of pharmaceutics

    pub_type: 杂志文章

    doi:10.1016/s0378-5173(00)00700-6

    authors: Zhu H,Grant DJ

    更新日期:2001-03-14 00:00:00