当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres.

pH-sensitive and mucoadhesive thiolated Eudragit-coated chitosan microspheres.

Abstract：

:The aim of this study was using Eudragit-cysteine conjugate to coat on chitosan microspheres (CMs) for developing an oral protein drug delivery system, having mucoadhesive and pH-sensitive property. Bovine serum albumin (BSA) as a protein model drug was loaded in thiolated Eudragit-coated CMs (TECMs) to study the release character of the delivery system. After thiolated Eudragit coating, it was found that the release rate of BSA from BSA-loaded TECMs was observably suppressed at pH 2.0 PBS solution, while at pH 7.4 PBS solution the BSA can be sustainingly released for several hours. The structural integrity of BSA released from BSA-loaded TECMs was guaranteed by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and circular dichroism (CD) spectroscopy. The mucoadhesive property of TECMs was evaluated and compared with CMs and Eudragit-coated chitosan microspheres (ECMs). It was confirmed that after coating thiolated Eudragit, the percentage of TECMs remained on the isolated porcine intestinal mucosa surface was significantly higher than those of CMs and ECMs. Likewise, gamma camera imaging of Tc-99m labeled microsphere distribution in rats after oral administration also suggested that TECMs had comparatively stronger mucoadhesive characters. Therefore, our results indicated that TECMs have potentials to be an oral protein drug carrier.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Quan JS,Jiang HL,Kim EM,Jeong HJ,Choi YJ,Guo DD,Yoo MK,Lee HG,Cho CS

doi

10.1016/j.ijpharm.2008.04.003

subject

Has Abstract

pub_date

2008-07-09 00:00:00

pages

205-10

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(08)00277-9

journal_volume

359

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Inhalation treatment of idiopathic pulmonary fibrosis with curcumin large porous microparticles.

    abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high mortality and poor prognosis. Curcumin shows anti-inflammatory effect by suppressing pro-inflammatory cytokines and inhibiting NF-κB mediated inflammation. Here, we developed inhalable curcumin-loaded poly(lactic-co-glycolic)acid ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.09.031

    authors： Hu Y,Li M,Zhang M,Jin Y

    更新日期：2018-11-15 00:00:00

  • Zinc delivery from non-woven fibres within a therapeutic nipple shield.

    abstract：:A Therapeutic Nipple Shield (TNS) was previously developed to respond to the global need for new infant therapeutic delivery technologies. However, the release efficiency for the same Active Pharmaceutical Ingredient (API) from different therapeutic matrices within the TNS formulation has not yet been investigated. To...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.12.042

    authors： Maier T,Scheuerle RL,Markl D,Bruggraber S,Zeitler A,Fruk L,Slater NKH

    更新日期：2018-02-15 00:00:00

  • The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers.

    abstract：:The aim of this study was to establish a correlation between carrier characteristics and the dispersibility of drug from the blend. The influence of the roughness of a commonly used carrier material, lactose monohydrate, on the adhesion, dose uniformity, and aerodynamic properties of a model drug, terbutaline sulphate...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.02.002

    authors： Flament MP,Leterme P,Gayot A

    更新日期：2004-05-04 00:00:00

  • Physico-chemical characterisation and transfection efficiency of lipid-based gene delivery complexes.

    abstract：:Cationic liposomes spontaneously interact with negatively charged plasmid DNA to form a transfection competent complex capable of promoting the expression of a therapeutic gene. This work aims to improve the understanding of the poorly defined mechanisms and structural rearrangements associated with the lipid-DNA inte...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00117-9

    authors： Birchall JC,Kellaway IW,Mills SN

    更新日期：1999-06-25 00:00:00

  • Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action.

    abstract：:This paper examines a perspective to use newly engineered nanomaterials as effective and safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers (PAMAM, phosphorus, and carbosilane) were complexed with anticancer siRNA and the biophysical properties of the dendriplexes created were anal...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.03.034

    authors： Dzmitruk V,Szulc A,Shcharbin D,Janaszewska A,Shcharbina N,Lazniewska J,Novopashina D,Buyanova M,Ionov M,Klajnert-Maculewicz B,Gómez-Ramirez R,Mignani S,Majoral JP,Muñoz-Fernández MA,Bryszewska M

    更新日期：2015-05-15 00:00:00

  • Preparation and characterization of the ion-fixed mixed micelles with superior stability.

    abstract：:The inherent instability of micelles remains a main challenge for antitumor drug delivery, the objective of this study is to prepare and characterize the ion-fixed mixed micelles with significantly improved stability. The mixed micelles and ion-fixed mixed micelles combining the carboxy-containing PLA (PLA-COO(-)) and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.011

    authors： Li Y,Fu Y,Guo H,Zhang L,Huang L,Yang L

    更新日期：2015-07-15 00:00:00

  • Interaction of biodegradable nanoparticles with intestinal cells: the effect of surface hydrophilicity.

    abstract：:The aim of the present work was to study the influence of surface hydrophilicity of biodegradable polymeric nanoparticles on cellular uptake by Caco-2 cells. Poly(D,L-lactide-co-glycolide acid) particles loaded with a fluorescent dye, 3,3'-dioctadecyloxacarbo-cyanine perchlorate (DiO), were prepared by the emulsion-ev...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.10.008

    authors： Gaumet M,Gurny R,Delie F

    更新日期：2010-05-05 00:00:00

  • Predicting the solubility-permeability interplay when using cyclodextrins in solubility-enabling formulations: model validation.

    abstract：:Although the extraordinary solubility advantage afforded by cyclodextrins has led to their widespread use as pharmaceutical solubilizers, several reports have emerged that cyclodextrins may also reduce the apparent permeability of the drug. With the purpose to investigate this solubility-permeability interplay, we hav...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.03.017

    authors： Miller JM,Dahan A

    更新日期：2012-07-01 00:00:00

  • Amino Acid-functionalized hollow mesoporous silica nanospheres as efficient biocompatible drug carriers for anticancer applications.

    abstract：:Herein, a series of new amino acid-functionalized hollow mesoporous silica nanospheres (HMSNs) by post-grafting methods were prepared. These new materials were characterized by different techniques and were studied as matrices for the antineoplastic drug (cisplatin) transport and delivery. The results demonstrate that...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118709

    authors： Ezzati N,Mahjoub AR,Abolhosseini Shahrnoy A,Syrgiannis Z

    更新日期：2019-12-15 00:00:00

  • Correlation between the stability constant and pH for β-cyclodextrin complexes.

    abstract：:In drug formulations, cyclodextrins are used to increase aqueous solubility and chemical stability of drugs via formation of inclusion complexes. For ionizable drug molecules, the complexation strength depends on pH. Increased ionization leads to a more soluble drug, but also results in destabilization of cyclodextrin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118523

    authors： Samuelsen L,Holm R,Lathuile A,Schönbeck C

    更新日期：2019-09-10 00:00:00

  • Penetration of topical and oral ofloxacin into the aqueous and vitreous humor of inflamed rabbit eyes.

    abstract：PURPOSE:This study aimed to investigate the penetration of topical and oral ofloxacin into aqueous humor and vitreous humor in post-traumatic endophthalmitis model in rabbits. METHODS:A standardized intraocular infection after penetrating injury was made in the right eyes of 16 rabbits. Intraocular infection was induc...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00482-8

    authors： Oztürk F,Kurt E,Inan UU,Kortunay MC,Ilker SS,Başci NE,Bozkurt A

    更新日期：2000-08-25 00:00:00

  • Optimisation of glutathione conjugation to liposomes quantified with a validated HPLC assay.

    abstract：:Glutathione (GSH) grafted onto nanoliposomes (GSH-liposomes) have the potential to enhance drug delivery into the brain. GSH is known to be an unstable tripeptide, however, despite widespread use to promote active transport its stability has been largely ignored to date. Therefore this study focuses on the optimisatio...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118451

    authors： Reginald-Opara JN,Svirskis D,O'Carroll SJ,Sreebhavan S,Dean JM,Wu Z

    更新日期：2019-08-15 00:00:00

  • In vitro simulation of drug intestinal absorption.

    abstract：:In this work, a simple set-up was designed, realized and tested to evaluate the effect of intestinal absorption on the in vitro drug release studies. The conventional USP-approved dissolution apparatus 2 was equipped with an hollow fibers filter, along with the necessary tubing and pumps, to simulate the two-fluids re...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.10.012

    authors： Lamberti G,Cascone S,Iannaccone M,Titomanlio G

    更新日期：2012-12-15 00:00:00

  • Composite scaffold obtained by electro-hydrodynamic technique for infection prevention and treatment in bone repair.

    abstract：:Bone infection is a devastating condition resulting from implant or orthopaedic surgery. Therapeutic strategies are extremely complicated and may result in serious side effects or disabilities. The development of enhanced 3D scaffolds, able to promote efficient bone regeneration, combined with targeted antibiotic rele...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.12.002

    authors： Aragón J,Feoli S,Irusta S,Mendoza G

    更新日期：2019-02-25 00:00:00

  • Novel combination of non-invasive morphological and solid-state characterisation of drug-loaded core-shell electrospun fibres.

    abstract：:In recent years, core-shell nanofibrous drug delivery systems have received increasing attention due to their ability to incorporate two or more active pharmaceutical ingredients (APIs) individually into the desired layer (either core or sheath) and thereby finely tune the release profiles of even incompatible drugs i...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119706

    authors： Kazsoki A,Farkas A,Balogh-Weiser D,Mancuso E,Sharma PK,Lamprou DA,Zelkó R

    更新日期：2020-09-25 00:00:00

  • Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: An in vivo study.

    abstract：:Topical preparations of capsaicin, the major pungent ingredient of hot pepper, are being used for management of pain and inflammatory disorders. Purpose of this study was to use nanoemulsion as an effective topical drug carrier for in vivo delivery of capsaicin. An oil-in-water nanoemulsion containing capsaicin was pr...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.01.043

    authors： Ghiasi Z,Esmaeli F,Aghajani M,Ghazi-Khansari M,Faramarzi MA,Amani A

    更新日期：2019-03-25 00:00:00

  • Structure elucidation and formation mechanistic study of a methylene-bridged pregabalin dimeric degradant in pregabalin extended-release tablets.

    abstract：:During the pharmaceutical development of pregabalin extended-release tablets, an unknown degradant at a relative retention time (RRT) of 11.7 was observed and its nominal amount exceeded the ICH identification threshold in an accelerated stability study. The aim of this study is to identify the structure and investiga...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.118910

    authors： Tian Y,Lin J,Chen F,Wang S,Li D,Kuang Z,Zhu W,Li Y,Zheng T,Cao W,Zhu B,Tsai E,Fu L,Li M

    更新日期：2020-02-15 00:00:00

  • Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.

    abstract：:The purpose of this study was to engineer nanoparticles with various sustained profiles of drug release and prolonged circulation by blending poly(D,L-lactic acid)/poly(D,L-lactic/glycolic acid) (PLA/PLGA) homopolymers and poly(ethylene glycol) (PEG)-block-PLA/PLGA copolymers encapsulating betamethasone disodium 21-ph...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.001

    authors： Ishihara T,Kubota T,Choi T,Takahashi M,Ayano E,Kanazawa H,Higaki M

    更新日期：2009-06-22 00:00:00

  • Solid lipid nanoparticles as drug carriers for topical glucocorticoids.

    abstract：:Recent investigations both in vitro and in human subjects proved the benefit/risk ratio of prednicarbate (PC) to exceed those of halogenated topical glucocorticoids about 2-fold. To obtain a further highly desired increase by drug targeting to viable epidermis, PC was incorporated into solid lipid nanoparticles (SLN)....

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00413-5

    authors： Maia CS,Mehnert W,Schäfer-Korting M

    更新日期：2000-03-10 00:00:00

  • Enhancing effect of surfactants on fexofenadine.HCl transport across the human nasal epithelial cell monolayer.

    abstract：:The effect of various surfactants (sodium cholate, sodium taurocholate, Tween 80 and Poloxamer F68) on enhancing the transepithelial permeability of fexofenadine.HCl was evaluated in a human nasal epithelial cell monolayer model. The cytotoxicity of the surfactants on the human nasal epithelial cells was evaluated by ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.043

    authors： Lin H,Gebhardt M,Bian S,Kwon KA,Shim CK,Chung SJ,Kim DD

    更新日期：2007-02-07 00:00:00

  • Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

    abstract：:The purpose of the study is to screen the interactions of fourth generation fluoroquinolone-gatifloxacin with efflux pumps, i.e., P-gp, MRP2 and BCRP. Mechanism of gatifloxacin interaction with efflux transporters may explain its acquired resistance. Such clarification may lead to the development of strategies to over...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.05.027

    authors： Kwatra D,Vadlapatla RK,Vadlapudi AD,Pal D,Mitra AK

    更新日期：2010-08-16 00:00:00

  • Marinosomes, marine lipid-based liposomes: physical characterization and potential application in cosmetics.

    abstract：:Marinosomes are liposomes based on a natural marine lipid extract containing a high polyunsaturated fatty acid (PUFA) ratio. They were prepared and characterized in conditions that mimic that of topical application in terms of pH, temperature and calcium. Marinosomes were stable in storage conditions for 1 month. At l...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00217-x

    authors： Moussaoui N,Cansell M,Denizot A

    更新日期：2002-08-21 00:00:00

  • Combination of PLGA nanoparticles with mucoadhesive guar-gum films for buccal delivery of antihypertensive peptide.

    abstract：:Oral administration of proteins and peptides still is a challenging task to overcome due to low permeability through absorptive epithelia, degradation and metabolism that lead to poor bioavailability. Attempting to overcome such limitations, an antihypertensive peptide derived from whey protein, with KGYGGVSLPEW seque...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.05.051

    authors： Castro PM,Baptista P,Madureira AR,Sarmento B,Pintado ME

    更新日期：2018-08-25 00:00:00

  • 3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach.

    abstract：:Three-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate integration into healthcare, non-destructive characterisation techniques are required to ensure final product quality. Here, the us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.08.002

    authors： Trenfield SJ,Goyanes A,Telford R,Wilsdon D,Rowland M,Gaisford S,Basit AW

    更新日期：2018-10-05 00:00:00

  • Solid-state compatibility studies using a high-throughput and automated forced degradation system.

    abstract：:As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is capable of handling more compounds in shorter times. In this paper, the establishment of a high-throughput automated powder compatibility testing system is reported. The integrated robotic system automatica...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.002

    authors： Wakasawa T,Sano K,Hirakura Y,Toyo'oka T,Kitamura S

    更新日期：2008-05-01 00:00:00

  • Carrier mediated uptake of L-tyrosine and its competitive inhibition by model tyrosine linked compounds in a rabbit corneal cell line (SIRC)--strategy for the design of transporter/receptor targeted prodrugs.

    abstract：:The objective of this study was to investigate the presence of amino acid transporters on the corneal epithelium and to enhance corneal drug absorption through prodrug modification targeted to the amino acid transporters. SIRC was used as a model cell line representing the corneal epithelium. Uptake studies were carri...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00405-2

    authors： Balakrishnan A,Jain-Vakkalagadda B,Yang C,Pal D,Mitra AK

    更新日期：2002-10-24 00:00:00

  • The place of dosage form innovation and the OTC market: the price to pay.

    abstract：AIMS AND OBJECTIVES:The aims and objectives of this article are to provide a background to the innovations that are made in over the counter market and to outline the time and costs involved in these activities. ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.042

    authors： Goggin PL

    更新日期：2014-08-05 00:00:00

  • The application of STEP-technology® for particle and protein dispersion detection studies in biopharmaceutical research.

    abstract：:Particle detection and analysis techniques are essential in biopharmaceutical industries to evaluate the quality of various parenteral formulations regarding product safety, product quality and to meet the regulations set by the authority agencies. Several particle analysis systems are available on the market, but for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.03.050

    authors： Gross-Rother J,Herrmann N,Blech M,Pinnapireddy SR,Garidel P,Bakowsky U

    更新日期：2018-05-30 00:00:00

  • Dipeptide prodrug approach to evade efflux pumps and CYP3A4 metabolism of lopinavir.

    abstract：:Oral absorption of lopinavir (LPV) is limited due to P-glycoprotein (P-gp) and multidrug resistance-associated protein2 (MRP2) mediated efflux by intestinal epithelial cells. Moreover, LPV is extensively metabolized by CYP3A4 enzymes. In the present study, dipeptide prodrug approach was employed to circumvent efflux p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.09.035

    authors： Patel M,Sheng Y,Mandava NK,Pal D,Mitra AK

    更新日期：2014-12-10 00:00:00

  • Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication.

    abstract：:Organic solvent extraction/evaporation from an o/w-dispersion has been widely used for the fabrication of PLGA microparticles. The purpose of this work was to elucidate the kinetics of the solvent extraction/evaporation process. A mathematical diffusion model was developed and applied to predict the duration of the so...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.015

    authors： Katou H,Wandrey AJ,Gander B

    更新日期：2008-11-19 00:00:00