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Anticancer siRNA cocktails as a novel tool to treat cancer cells. Part (B). Efficiency of pharmacological action.

Abstract：

:This paper examines a perspective to use newly engineered nanomaterials as effective and safe carriers for gene therapy of cancer. Three different groups of cationic dendrimers (PAMAM, phosphorus, and carbosilane) were complexed with anticancer siRNA and the biophysical properties of the dendriplexes created were analyzed. The potential of the dendrimers as nanocarriers for anticancer Bcl-xl, Bcl-2, Mcl-1 siRNAs and additionally a scrambled sequence siRNA has been explored. Dendrimer/siRNA complexes were characterised by various methods including fluorescence, zeta potential, dynamic light scattering, circular dichroism, gel electrophoresis and transmission electron microscopy. In this part of study, the transfection of complexes in HeLa and HL-60 cells was analyzed using both single apoptotic siRNAs and a mixture (cocktail) of them. Cocktails were more effective than single siRNAs, allowing one to decrease siRNAs concentration in treating cells. The dendrimers were compared as siRNA carriers, the most effective being the phosphorus-based ones. However, they were also the most cytotoxic on their own, so that in this regard the application of all dendrimers in anticancer therapy will be discussed.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Dzmitruk V,Szulc A,Shcharbin D,Janaszewska A,Shcharbina N,Lazniewska J,Novopashina D,Buyanova M,Ionov M,Klajnert-Maculewicz B,Gómez-Ramirez R,Mignani S,Majoral JP,Muñoz-Fernández MA,Bryszewska M

doi

10.1016/j.ijpharm.2015.03.034

subject

Has Abstract

pub_date

2015-05-15 00:00:00

pages

288-94

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(15)00250-1

journal_volume

485

pub_type

杂志文章

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