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Oral delivery of oleuropein-loaded lipid nanocarriers alleviates inflammation and oxidative stress in acute colitis.

Abstract：

:Inflammation and oxidative stress pathways have emerged as novel targets in the management of inflammatory bowel diseases (IBD). Targeting the drug to the inflamed colon remains a challenge. Nanostructured lipid carriers (NLCs) have been reported to accumulate in inflamed colonic mucosa. The antioxidant/antiinflamatory polyphenol oleuropein (OLE) was loaded in NLCs (NLC-OLE). NLC-OLE showed to be more effective in decreasing the TNF-α secretion and intracellular reactive oxygen species (ROS) by activated macrophages (J774) compared to the conventional form of OLE. OLE efficacy was preserved within NLC-OLE ameliorating inflammation in a murine model of acute colitis: reduced levels of TNF-α and IL-6, decreased neutrophil infiltration and improved histopathology of the colon were reported. In addition, NLC-OLE enhanced the ROS scavenging activity of OLE in the colon after oral administration. These data suggest that the proposed NLC-OLE could be a promising drug delivery system for OLE in IBD treatment.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Huguet-Casquero A,Xu Y,Gainza E,Pedraz JL,Beloqui A

doi

10.1016/j.ijpharm.2020.119515

subject

Has Abstract

pub_date

2020-08-30 00:00:00

pages

119515

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(20)30499-3

journal_volume

586

pub_type

杂志文章

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