Abstract:
:A substantial drug release from poly(lactic-co-glycolic) acid (PLGA) micro- and nanoparticles can occur in the first hours of immersion, which is referred to as burst release. A strong burst release (when not intentional) is to be avoided as it decreases the efficacy of the treatment and could be dangerous to the host. In this work we analyze the total amount of drug released during burst and respective kinetics in relation to formulations characteristics, experimental conditions and drug molecular properties in 154 drug release experiments with 41 different drugs by partial least squares (PLS) and decision tree regression. The model created enables to quantify to which degree the physicochemical parameters control the burst release from PLGA particles. Our analysis shows that the amount of drug released during burst is mostly influenced by the formulation characteristics and the synthesis parameters, whereas the drug release kinetics is also influenced by the molecular properties of the drug. The variables that significantly influence the amount and kinetics of the burst release are discussed in detail and compared with findings from other researchers. The final regression models are shown to predict the release profile of a new drug, opening the possibility to be applied to systematically manipulate the burst release by means of designing an optimized drug delivery system.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Rodrigues de Azevedo C,von Stosch M,Costa MS,Ramos AM,Cardoso MM,Danhier F,Préat V,Oliveira Rdoi
10.1016/j.ijpharm.2017.08.118subject
Has Abstractpub_date
2017-10-30 00:00:00pages
229-240issue
1eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30835-9journal_volume
532pub_type
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