Abstract：
:Various biomacromolecules (BMs) such as proteins, DNA, and carbohydrates are extremely difficult to be dissolved in a single organic solvent phase for sustained release or targeted delivery formulation. In this study, three different BMs could be solubilized in selected organic solvents by forming poly(ethylene glycol) (PEG)-assisted nano-complexes while maintaining their structural integrity. Dynamic light scattering (DLS) and atomic force microscopy (AFM) analysis revealed that proteins, DNA, and carbohydrate polymers could be nano-complexed with PEG in various organic solvents. The diameter of nano-complexes decreased roughly from approximately 600 nm to approximately 100 nm with increasing weight ratio of PEG/BM. The present solubilization technique could be potentially applied for sustained release formulations of various therapeutic biological drugs.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Mok H,Kim HJ,Park TGdoi
10.1016/j.ijpharm.2008.01.033subject
Has Abstractpub_date
2008-05-22 00:00:00pages
306-13issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(08)00017-3journal_volume
356pub_type
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