Abstract：
:Chitosan-based nanoparticles prepared by ionotropic gelation are prone to stability issues. The aim of this work is to chemically modify chitosan by grafting to succinate, phthalate, glutarate and phenylsuccinate moieties and to investigate the suitability of the resulting polymers as covalently-crosslinked nanocarriers. Corresponding nanoparticles (NPs) were formulated by ionotropic gelation using tripolyphosphate (TPP) anion then they were covalently crosslinked using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). Infrared and thermal analysis confirmed the formation of phosphoramide bonds within the NPs indicating the involvement of TPP in covalent crosslinking. This is the first time to report phosphormide covalent crosslinking within nanoparticles matrices. The resulting NPs were found to resist drastic pH and calcium ion conditions. Size analysis indicated the NPs to be spherical and less than 500nm in diameter. Loading studies using Safranine O showed enhanced NPs drug loading upon covalent crosslinking compared to ionotropic gelling. Doxorubicin-loaded NPs were of superior cytotoxic properties compared to free doxorubicin.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Dmour I,Taha MOdoi
10.1016/j.ijpharm.2017.06.061subject
Has Abstractpub_date
2017-08-30 00:00:00pages
15-31issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30569-0journal_volume
529pub_type
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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pub_type： 杂志文章
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更新日期：2008-06-05 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2006-08-17 00:00:00
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更新日期：2019-03-10 00:00:00
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更新日期：2006-02-17 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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更新日期：2007-04-20 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,随机对照试验
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