Abstract：
:Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes such as the coating. In this context, there is an urgent need for approaches to overcome the occurrences of capping and lamination. In the present study, a novel lower punch vibration technique was used to decrease the capping or lamination tendency of different powder formulations. Different microcrystalline cellulose types, as well as an API (acetaminophen), were selected as model powders. The powders were investigated regarding their powder flow, density, particle morphology, and surface area. Moreover, the manufactured tablets were characterized regarding their tablet weight, tensile strength, and capping or lamination indices. It was shown that the capping or lamination tendency was strongly affected by the physical powder properties, the formulation composition, and the adjusted turret speed. In addition, the application of externally applied lower punch vibration led to a pronounced decrease of the capping or lamination tendency and improved mechanical stability of the manufactured tablets.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Kalies A,Heinrich T,Leopold CSdoi
10.1016/j.ijpharm.2020.119195subject
Has Abstractpub_date
2020-04-30 00:00:00pages
119195eissn
0378-5173issn
1873-3476pii
S0378-5173(20)30179-4journal_volume
580pub_type
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