Abstract：
:Tuberculosis (TB) remains a major global health problem as it is the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). Conventional treatments fail either because of poor patient compliance to the drug regimen or due to the emergence of multidrug-resistant tuberculosis. The aim of this review is to give an update on the information available on tuberculosis, its pathogenesis and current antitubercular chemotherapies. Direct lung delivery of anti-TB drugs using pulmonary delivery systems is then reviewed since it appears as an interesting strategy to improve first and second line drugs. A particular focus is place on research performed on inhalable dry powder formulations of antitubercular drugs to target alveolar macrophages where the bacteria develop. Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release. Treatments of infected animals show a significant reduction of the number of viable bacteria as well as a decrease in tissue damage. These new formulations appear as interesting alternatives to deliver directly drugs to the lungs and favor efficient TB treatment.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Pham DD,Fattal E,Tsapis Ndoi
10.1016/j.ijpharm.2014.12.009subject
Has Abstractpub_date
2015-01-30 00:00:00pages
517-29issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(14)00897-7journal_volume
478pub_type
杂志文章,评审abstract：:Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed betwee...
journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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pub_type： 杂志文章,评审
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2011.01.041
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pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2011-11-25 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2010.04.021
更新日期：2010-06-30 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2012.03.044
更新日期：2012-07-01 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2017.04.027
更新日期：2017-06-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2018-08-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/s0378-5173(99)00368-3
更新日期：2000-01-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2016-09-25 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2001-10-09 00:00:00
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journal_title：International journal of pharmaceutics
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2000-04-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2014-11-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章,评审
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更新日期：2018-01-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2001-06-04 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2010.03.061
更新日期：2010-06-15 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2014-11-20 00:00:00
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journal_title：International journal of pharmaceutics
pub_type： 杂志文章
doi：10.1016/j.ijpharm.2017.05.061
更新日期：2017-08-07 00:00:00
abstract：:Regional drug delivery via dry powder inhalers offers many advantages in the management of pharmaceutical compounds for the prevention and treatment of respiratory diseases. In the present study, doxorubicin (DOX)-loaded nanoparticles were incorporated as colloidal drug delivery system into inhalable carrier particles...
journal_title：International journal of pharmaceutics
pub_type： 杂志文章
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更新日期：2006-08-17 00:00:00
