Abstract：
:The blending process is a key step in the production of dry powder inhaler formulations, but only little is known about the influence of process parameters. This is especially true for high shear blending of ternary formulations. For this reason, this study aims to investigate the influence of high shear mixing process parameters (mixing time and rotation speed) on the fine particle fraction (FPF) of ternary mixtures when using budesonide as model drug, two different carrier materials and two different mixing orders. Prolonged mixing time and higher rotation speeds led to lower FPFs, possibly due to higher press-on forces acting on the active pharmaceutical ingredients (API). In addition, a clear correlation between the energy consumption of the blender (the energy input into the blend) and the reduction of the FPF could be shown. Furthermore blending the carrier and the fines before adding the API was also found to be favorable.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Hertel M,Schwarz E,Kobler M,Hauptstein S,Steckel H,Scherließ Rdoi
10.1016/j.ijpharm.2017.10.033subject
Has Abstractpub_date
2017-12-20 00:00:00pages
242-250issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)31012-8journal_volume
534pub_type
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