当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery.

Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery.

Abstract：

:Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymers (PEOz-PLLA). PEOz-PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170 nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4-5). At 37 degrees C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24 h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72 h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Hsiue GH,Wang CH,Lo CL,Wang CH,Li JP,Yang JL

doi

10.1016/j.ijpharm.2006.03.002

subject

Has Abstract

pub_date

2006-07-06 00:00:00

pages

69-75

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(06)00197-9

journal_volume

317

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Inhalable co-amorphous budesonide-arginine dry powders prepared by spray drying.

    abstract：:Spray drying is a well-established technology to produce inhalable dry powders. However, the amorphous nature of the particles typically obtained from the process can lead to physically and chemically unstable products. The purpose of this study was to investigate whether spray-drying could be used as a manufacturing ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.04.036

    authors： Lu W,Rades T,Rantanen J,Yang M

    更新日期：2019-06-30 00:00:00

  • Glycyrrhizic acid as a multifunctional drug carrier - From physicochemical properties to biomedical applications: A modern insight on the ancient drug.

    abstract：:Glycyrrhizic acid is the main active component of Licorice root which has been known in traditional Chinese and Japanese medicine since ancient times. In these cultures glycyrrhizic acid (GA) is one of the most frequently used drugs. However, only in 21-st century a novel unusual property of the GA to enhance the acti...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2019.01.047

    authors： Selyutina OY,Polyakov NE

    更新日期：2019-03-25 00:00:00

  • Applications of NIR spectroscopy to monitoring and analyzing the solid state during industrial crystallization processes.

    abstract：:Fiber-optic near infrared (NIR) spectroscopy was used to investigate several key features of the polymorphic transitions observed during the crystallization and the filtration of SaC, an Active Pharmaceutical Ingredient (API) produced by Sanofi-Synthelabo. Using few samples, the spectroscopic data were calibrated to p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.003

    authors： Févotte G,Calas J,Puel F,Hoff C

    更新日期：2004-04-01 00:00:00

  • Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination.

    abstract：:This work reports a novel approach to the assessment of the surface properties of compacts used in Surface Dissolution Imaging (SDI). SDI is useful for determining intrinsic dissolution rate (IDR), an important parameter in early stage drug development. Surface topography, post-compaction and post-SDI run, have been m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.07.053

    authors： Ward A,Walton K,Box K,Østergaard J,Gillie LJ,Conway BR,Asare-Addo K

    更新日期：2017-09-15 00:00:00

  • The influence of buffer composition on tissue integrity during permeability experiments "in vitro".

    abstract：:A well-balanced incubation saline is necessary for permeability experiments with the rat jejunal tissue in the diffusion chambers. At the same time the investigated substance must be chemically stable and sufficiently soluble in this incubation saline. To investigate whether the absence of some ions in incubation sali...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2003.12.014

    authors： Zakelj S,Legen I,Veber M,Kristl A

    更新日期：2004-03-19 00:00:00

  • Characterization and antimicrobial activity of a pharmaceutical microemulsion.

    abstract：:The characterization of a pharmaceutical microemulsion system with glycerol monolaurate as oil, ethanol as cosurfactant, Tween 40 as surfactant, sodium diacetate and water, and the antimicrobial activities against Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Candida albicans, Aspergillus niger and Penic...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.05.022

    authors： Zhang H,Cui Y,Zhu S,Feng F,Zheng X

    更新日期：2010-08-16 00:00:00

  • Solid lipid nanoparticles as potential tools for gene therapy: in vivo protein expression after intravenous administration.

    abstract：:Naked plasmid DNA is a powerful tool for gene therapy, but it is rapidly eliminated from the circulation after intravenous administration. Therefore, the development of optimized DNA delivery systems is necessary for its successful clinical use. Solid lipid nanoparticles (SLNs) have demonstrated transfection capacity ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.10.020

    authors： del Pozo-Rodríguez A,Delgado D,Solinís MA,Pedraz JL,Echevarría E,Rodríguez JM,Gascón AR

    更新日期：2010-01-29 00:00:00

  • Phase behavior of itraconazole-phenol mixtures and its pharmaceutical applications.

    abstract：:The aims of this study were to examine the phase behavior of itraconazole-phenol mixtures and assess the feasibility of topical formulations of itraconazole using eutectic mixture systems. Itraconazole-phenol eutectic mixtures were characterized using differential scanning calorimetry, Fourier transform infrared spect...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.07.054

    authors： Park CW,Mansour HM,Oh TO,Kim JY,Ha JM,Lee BJ,Chi SC,Rhee YS,Park ES

    更新日期：2012-10-15 00:00:00

  • Polymeric nanoparticles encapsulating betamethasone phosphate with different release profiles and stealthiness.

    abstract：:The purpose of this study was to engineer nanoparticles with various sustained profiles of drug release and prolonged circulation by blending poly(D,L-lactic acid)/poly(D,L-lactic/glycolic acid) (PLA/PLGA) homopolymers and poly(ethylene glycol) (PEG)-block-PLA/PLGA copolymers encapsulating betamethasone disodium 21-ph...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.04.001

    authors： Ishihara T,Kubota T,Choi T,Takahashi M,Ayano E,Kanazawa H,Higaki M

    更新日期：2009-06-22 00:00:00

  • Liposomes encapsulating native and cyclodextrin enclosed paclitaxel: Enhanced loading efficiency and its pharmacokinetic evaluation.

    abstract：:Combination strategy involving cyclodextrin (CD) complexation and liposomal system was investigated for Paclitaxel (PTX) to improve loading. Complexation was done using 2,6-di-O-methylbetacyclodextrin (DMβCD). Sterically stabilized double loaded PEGylated liposomes (DLPLs) containing PTX and PTX-DMβCD complex were pre...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2017.11.048

    authors： Bhatt P,Lalani R,Vhora I,Patil S,Amrutiya J,Misra A,Mashru R

    更新日期：2018-01-30 00:00:00

  • Photodynamic ultradeformable liposomes: Design and characterization.

    abstract：:Hydrophobic ([tetrakis(2,4-dimetil-3-pentyloxi)-phthalocyaninate]zinc(II)) (ZnPc) and hydrophilic ([tetrakis(N,N,N-trimethylammoniumetoxi)-phthalocyaninate]zinc(II) tetraiodide) (ZnPcMet) phthalocyanines were synthesized and loaded in ultradeformable liposomes (UDL) of soybean phosphatidylcholine and sodium cholate (6...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.11.015

    authors： Montanari J,Perez AP,Di Salvo F,Diz V,Barnadas R,Dicelio L,Doctorovich F,Morilla MJ,Romero EL

    更新日期：2007-02-07 00:00:00

  • Optical surface roughness study of starch acetate compacts.

    abstract：:Optical surface roughness of starch acetate compacts was investigated by specular reflection of a laser beam as a function of angle of incidence. The intensity data was fitted using the model of Gaussian and Lorentzian curves to solve numerical values for optical surface roughness which was observed to be order of 1 m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00077-0

    authors： Silvennoinen R,Peiponen KE,Hyvärinen V,Raatikainen P,Paronen P

    更新日期：1999-05-25 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract：:Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.05.001

    authors： Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期：2014-08-25 00:00:00

  • Characterisation and stability studies of a hydrophilic decapeptide in different adjuvant drug delivery systems: a comparative study of PLGA nanoparticles versus chitosan-dextran sulphate microparticles versus DOTAP-liposomes.

    abstract：:Poly[lactic-co-glycolide] (PLGA) nanoparticles, chitosan-dextran sulphate microparticles, and DOTAP-liposomes were prepared as vaccine adjuvants and drug carriers for a small hydrophilic model peptide, and their different physico-chemical properties (size, PDI, zeta-potential, pH-value and peptide loading) were invest...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.09.011

    authors： Wieber A,Selzer T,Kreuter J

    更新日期：2011-12-12 00:00:00

  • Development of Ussing model coupled with artificial membrane for predicting intestinal absorption mechanisms of drugs.

    abstract：:The absorption mechanisms of drugs play an important role on development and various application of drugs. However, the present methods of absorption mechanisms are not perfect enough. Hence, exploring a novel method to accurately predict the absorption mechanisms is necessary. In this study, we developed an Ussing mo...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119170

    authors： Huang S,Huang Y,Yin X,Wang D,Xiang W,Wang M,Xia Z

    更新日期：2020-04-15 00:00:00

  • Development and characterisation of novel poly (vinyl alcohol)/poly (vinyl pyrrolidone)-based hydrogel-forming microneedle arrays for enhanced and sustained transdermal delivery of methotrexate.

    abstract：:Methotrexate (MTX) is one of the mainstays of treatment for rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) and it is mainly administered either orally or by subcutaneous (SC) injection, which are not so satisfactory. While orally administered MTX is associated with variable bioavailability and cause...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119580

    authors： Tekko IA,Chen G,Domínguez-Robles J,Thakur RRS,Hamdan IMN,Vora L,Larrañeta E,McElnay JC,McCarthy HO,Rooney M,Donnelly RF

    更新日期：2020-08-30 00:00:00

  • Functionalized single-walled carbon nanotubes: cellular uptake, biodistribution and applications in drug delivery.

    abstract：:The unique properties of single-walled carbon nanotubes (SWNTs) enable them to play important roles in many fields. One of their functional roles is to transport cargo into cell. SWNTs are able to traverse amphipathic cell membranes due to their large surface area, flexible interactions with cargo, customizable dimens...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.03.017

    authors： Li Z,de Barros ALB,Soares DCF,Moss SN,Alisaraie L

    更新日期：2017-05-30 00:00:00

  • Nutlin-3 loaded nanocarriers: Preparation, characterization and in vitro antineoplastic effect against primary effusion lymphoma.

    abstract：:In this investigation, Nutlin-3 (Nut3), a novel antitumor drug with low water solubility (<0.1mg/L at 25°C), was loaded into liposomes (Lipo-Nut3), polymeric nanoparticles (NPs-Nut3) and nanoparticles engineered with an antibody direct against Syndecan-1/CD 138 (Syn-NPs-Nut3) to obtain carriers targeted to PEL (primar...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.05.029

    authors： Belletti D,Tosi G,Riva G,Lagreca I,Galliania M,Luppi M,Vandelli MA,Forni F,Ruozi B

    更新日期：2015-07-25 00:00:00

  • Design of a fluid energy single vessel powder processor for pharmaceutical use.

    abstract：:This study introduces a motionless novel single vessel powder processor designed to carry out all of the unit operations in the preparation of powders for tableting. The processor used controllable fluid dynamics to provide the energy for each unit operation. The vessel design was evaluated using a computational fluid...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00033-2

    authors： Kay GR,Staniforth JN,Tobyn MJ,Horrill MD,Newnes LB,MacGregor SA,Li M,Atherton G,Lamming RC,Hajee DW

    更新日期：1999-04-30 00:00:00

  • Insulin containing polyethylenimine-dextran sulfate nanoparticles.

    abstract：:An aqueous nanoparticle delivery system has been developed which employs the oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS) with zinc as a stabilizer. It is found that the pH of PEI solutions, the weight ratio of the two polymers, and zinc sulfate concentrations all play significant roles ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(03)00055-3

    authors： Tiyaboonchai W,Woiszwillo J,Sims RC,Middaugh CR

    更新日期：2003-04-14 00:00:00

  • Poly(ε-caprolactone)/triclosan loaded polylactic acid nanoparticles composite: A long-term antibacterial bionanocomposite with sustained release.

    abstract：:In this study, the antibacterial bionanocomposites of poly(ε-caprolactone) (PCL) with different concentrations of triclosan (TC) loaded polylactic acid (PLA) nanoparticles (30wt% triclosan) (LATC30) were fabricated via a melt mixing process in order to lower the burst release of PCL and to extend the antibacterial act...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.05.009

    authors： Kaffashi B,Davoodi S,Oliaei E

    更新日期：2016-07-11 00:00:00

  • Dry powder inhalation of colistin sulphomethate in healthy volunteers: A pilot study.

    abstract：BACKGROUND:Pulmonary administration of the antimicrobial drugs colistin sulphomethate and tobramycin has been shown to be effective in slowing down pulmonary deterioration in cystic fibrosis (CF) patients. Both drugs are administered by liquid nebulisation, a technique known to have disadvantages. Dry powder inhalation...

    journal_title：International journal of pharmaceutics

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ijpharm.2006.11.021

    authors： Westerman EM,de Boer AH,Le Brun PPH,Touw DJ,Frijlink HW,Heijerman HGM

    更新日期：2007-04-20 00:00:00

  • Degradable dextran microspheres for the controlled release of liposomes.

    abstract：:A novel delivery concept based on the encapsulation of liposomes in biodegradable dextran microspheres was developed. The microspheres were prepared using a two-phase system, consisting of water/poly(ethylene glycol), and water/methacrylated dextran. Liposomes were encapsulated almost quantitatively and in their intac...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(00)00625-6

    authors： Stenekes RJ,Loebis AE,Fernandes CM,Crommelin DJ,Hennink WE

    更新日期：2001-02-19 00:00:00

  • Biopharmaceutic evaluation of novel anthelmintic (1H-benzimidazol-5(6)-yl)carboxamide derivatives.

    abstract：:Benzimidazole 2-carbamates, such as albendazole (ABZ) and mebendazole (MBZ), used for the treatment of helmintic infections, have low aqueous solubility and poor bioavailability, both of which lead to high interindividual variability when used for human systemic helmintiosis; therefore, it is necessary to search for n...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.05.013

    authors： Rivera JC,Yépez-Mulia L,Hernández-Campos A,Moreno-Esparza R,Castillo R,Navarrete-Vázquez G,Fuentes-Noriega I,Jung-Cook H

    更新日期：2007-10-01 00:00:00

  • Induction of immunogenic cell death of cancer cells through nanoparticle-mediated dual chemotherapy and photothermal therapy.

    abstract：:The use of nanomedicines to induce immunogenic cell death is a new strategy that aims to increase tumor immunogenicity and thereby prime tumors for further immunotherapies. In this study, we developed a nanoparticle formulation for combinatory chemotherapy and photothermal therapy based only on materials previously us...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119787

    authors： Heshmati Aghda N,Abdulsahib SM,Severson C,Lara EJ,Torres Hurtado S,Yildiz T,Castillo JA,Tunnell JW,Betancourt T

    更新日期：2020-09-06 00:00:00

  • New studies on leachables in commercial scale protein drug filling lines using stir bar sorptive extraction coupled with TD-GC-MS and UPLC/QTOF-MS/MS analytics.

    abstract：:The increasing application of Single-Use Systems (SUSs) in pharmaceutical manufacturing lines poses a potential risk of polymer-related impurities leaching into the process stream and persisting through the manufacturing process. To minimize any potential toxicity and impairment to the product's quality, safety thresh...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2018.11.033

    authors： Scherer N,Marcseková K,Posset T,Winter G

    更新日期：2019-01-30 00:00:00

  • Physicochemical characterisation of liposomes with encapsulated local anaesthetics.

    abstract：:Local anaesthetics may be added to intravenous o/w emulsions of propofol to reduce the initial pain of injection. Due to incompatibility problems of the emulsion on the addition of a local anaesthetic solution, prior encapsulation of the drug within liposomes is suggested. The liposomes were prepared with the sonicati...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.01.015

    authors： Müller M,Mackeben S,Müller-Goymann CC

    更新日期：2004-04-15 00:00:00

  • Preparation and characterisation of hexamidine salts.

    abstract：:Hexamidine diisethionate (HEX D) has been used in the personal care industry and in a number of over-the-counter (OTC) drug products as an antimicrobial agent since the 1950's. Recently, the compound has also been investigated for its beneficial effects on skin health. Surprisingly, there is only limited information d...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2015.07.071

    authors： Parisi N,Matts PJ,Lever R,Hadgraft J,Lane ME

    更新日期：2015-09-30 00:00:00

  • Evolution of Cyclodextrin Nanosponges.

    abstract：:Cyclodextrin-based nanosponges (CD-NSs) are insoluble, highly cross-linked 3D network polymers used in several scientific and technological fields, the main area of investigation concerns the pharmaceutical applications, in which CD-NSs have been mostly employed as drug delivery systems. CD-NSs can be generally groupe...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2017.06.072

    authors： Caldera F,Tannous M,Cavalli R,Zanetti M,Trotta F

    更新日期：2017-10-15 00:00:00

  • Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods.

    abstract：:We report the preparation and evaluation of flurbiprofen loaded-poly-epsilon-caprolactone nanospheres obtained by solvent displacement method. Characterization by thermal methods, infrared spectroscopy and X-ray diffraction analysis can reveal the dispersion state of the drug inside the nanospheres. Such information p...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(98)00381-0

    authors： Gamisans F,Lacoulonche F,Chauvet A,Espina M,García ML,Egea MA

    更新日期：1999-03-01 00:00:00