Abstract:
:The unique properties of single-walled carbon nanotubes (SWNTs) enable them to play important roles in many fields. One of their functional roles is to transport cargo into cell. SWNTs are able to traverse amphipathic cell membranes due to their large surface area, flexible interactions with cargo, customizable dimensions, and surface chemistry. The cargoes delivered by SWNTs include peptides, proteins, nucleic acids, as well as drug molecules for therapeutic purpose. The drug delivery functions of SWNTs have been explored over the past decade. Many breakthrough studies have shown the high specificity and potency of functionalized SWNT-based drug delivery systems for the treatment of cancers and other diseases. In this review, we discuss different aspects of drug delivery by functionalized SWNT carriers, diving into the cellular uptake mechanisms, biodistribution of the delivery system, and safety concerns on degradation of the carriers. We emphasize the delivery of several common drugs to highlight the recent achievements of SWNT-based drug delivery.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Li Z,de Barros ALB,Soares DCF,Moss SN,Alisaraie Ldoi
10.1016/j.ijpharm.2017.03.017subject
Has Abstractpub_date
2017-05-30 00:00:00pages
41-54issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(17)30193-Xjournal_volume
524pub_type
杂志文章,评审abstract::To examine whether the dietary lectin wheat germ agglutinin (WGA) can facilitate binding and uptake of protein drugs due to its cytoadhesive and cytoinvasive properties, conjugates were prepared by covalent coupling of fluorescein-labeled bovine serum albumin (F-BSA) to WGA using divinylsulfone for crosslinking. Incre...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/s0378-5173(02)00049-2
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abstract::Nanoparticles comprising copolymers of aminoethylcarbamoyl-beta-cyclodextrin (AEC-beta-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25-10.0% (w/w) water and 5.0% (w/w) surfactant (MO-3S...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
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doi:10.1016/j.ijpharm.2009.08.021
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journal_title:International journal of pharmaceutics
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abstract::Multiple sclerosis (MS) is the most common demyelinating disease. Despite the historical use of interferon-beta (IFN-β) for the treatment of patients with MS, concerns exist regarding the side effects of IFN-β. In this study, we designed a series of novel IFN-β fusion proteins containing galectin-9 (gal-9), which exer...
journal_title:International journal of pharmaceutics
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abstract::Topical aciclovir cream (ACV, Zovirax Cream) containing 40% propylene glycol (PG), the optimum found for skin penetration, is clinically effective in the treatment of recurrent herpes labialis. One hundred and thirty-nine ACV generic creams were analysed and 80% of these contained less than 20% PG. From this, we hypot...
journal_title:International journal of pharmaceutics
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doi:10.1016/j.ijpharm.2005.07.020
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abstract:UNLABELLED:The aim of this study is to validate the ability of the disappearance model to predict absorption rates of insulin aspart in pigs. The disappearance model is used as a screening tool to estimate absorption rates after subcutaneous injections in humans or pigs especially of insulin and insulin analogues. The ...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2006.09.004
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2000-04-20 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2009.06.034
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pub_type: 杂志文章
doi:10.1016/j.ijpharm.2020.119706
更新日期:2020-09-25 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/s0378-5173(02)00147-3
更新日期:2002-08-21 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2009.07.010
更新日期:2009-11-03 00:00:00
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更新日期:2020-06-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2013.02.022
更新日期:2013-04-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/s0378-5173(02)00542-2
更新日期:2003-01-16 00:00:00
abstract:PURPOSE:Application of spray-dried chitinosans as excipients for use in drug delivery systems was explored. METHODS:Spray- and tray-dried chitinosans previously N-deacetylated and depolymerized were used. Directly compressed tablets (200mg) containing tetracycline, chitinosan, and magnesium stearate were prepared. The...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/s0378-5173(02)00605-1
更新日期:2003-02-18 00:00:00
abstract::The development of sunscreens containing reduced concentration of chemical UV filters, even though, possessing broad spectrum effectiveness with the use of natural raw materials that improve and infer UV absorption is of great interest. Due to the structural similarities between polyphenolic compounds and organic UV f...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2008.06.031
更新日期:2008-11-03 00:00:00
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更新日期:2018-10-05 00:00:00
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2020-10-15 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2015.04.058
更新日期:2015-07-05 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00