Flurbiprofen-loaded nanospheres: analysis of the matrix structure by thermal methods.

abstract：:A new class of surfactants with glycerate headgroups, that form viscous lyotropic liquid crystalline phases in excess water, have been investigated for their potential to provide sustained release matrices for depot drug delivery. Oleyl glycerate and phytanyl glycerate were used as representative surfactants of this n...

journal_title：International journal of pharmaceutics

authors： Boyd BJ,Whittaker DV,Khoo SM,Davey G

更新日期：2006-02-17 00:00:00

abstract：:Telmisartan (TEL) belongs to BCS class II (low solubility/high permeability) and exhibits the pH-dependent drug release. Since 3-aminopropyl functionalized magnesium phyllosilicate (aminoclay) can intercalate or adsorb the negatively charged molecules via the electrostatic interaction, TEL-aminoclay complex was synthe...

journal_title：International journal of pharmaceutics

authors： Yang L,Shao Y,Han HK

更新日期：2014-08-25 00:00:00

abstract：:With the increasing number of misuse and abuse of opioids, the resistance to tampering becomes an important attribute for transdermal opioid patches. In this study, drug-containing geopolymer granules were integrated into an adhesive matrix to improve the resistance of fast drug release against some common abuse techn...

journal_title：International journal of pharmaceutics

authors： Cai B,Engqvist H,Bredenberg S

更新日期：2015-07-05 00:00:00

abstract：:This work presents a simple and fast method for the simultaneous determination of amiloride and furosemide by digital derivative spectrophotometry. HCl 1 x 10(-2) mol/l dissolved in ethanol was used as solvent and to extract drugs from formulations. Subsequently the samples were evaluated directly by first digital der...

journal_title：International journal of pharmaceutics

authors： Inés Toral M,Pope S,Quintanilla S,Richter P

更新日期：2002-12-05 00:00:00

abstract：:HL235 is a new cathepsin K inhibitor designed and synthesized to treat osteoporosis. Since HL235 has poor aqueous solubility, a self-microemulsifying drug delivery system (SMEDDS) was formulated to enhance its oral bioavailability. A solubility study of HL235 was performed to select a suitable oil, surfactant and cosu...

journal_title：International journal of pharmaceutics

authors： Visetvichaporn V,Kim KH,Jung K,Cho YS,Kim DD

更新日期：2020-01-05 00:00:00

abstract：:Nanoparticles comprising copolymers of aminoethylcarbamoyl-beta-cyclodextrin (AEC-beta-CD) and ethylene glycol diglycidyl ether (EGDGE) are prepared by an interfacial polyaddition reaction in a miniemulsion system. Polymers are formed in a W/O emulsion containing 0.25-10.0% (w/w) water and 5.0% (w/w) surfactant (MO-3S...

journal_title：International journal of pharmaceutics

authors： Eguchi M,Du YZ,Ogawa Y,Okada T,Yumoto N,Kodaka M

更新日期：2006-03-27 00:00:00

abstract：:Cyclosporin A (CyA) is a lipophilic, cyclic polypeptide drug with anti-inflammatory properties. It is used in topical treatment of dry eyes and is now commercially available in oil based surfactant containing eye drops. Surfactants can irritate the eye surface causing burning, itching and irritation of the conjunctiva...

journal_title：International journal of pharmaceutics

authors： Jóhannsdóttir S,Jansook P,Stefánsson E,Loftsson T

更新日期：2015-09-30 00:00:00

abstract：:A new system for prediction of drug absorption that takes into account drug dissolution and pH change in the gastro-intestinal tract was developed. In this new system, a drug (solid form) is added into a drug-dissolving vessel (pH 1.0) and the dissolved drug is transferred to a pH adjustment vessel (pH 6.0). Then the ...

journal_title：International journal of pharmaceutics

authors： Kobayashi M,Sada N,Sugawara M,Iseki K,Miyazaki K

更新日期：2001-06-19 00:00:00

abstract：:The concept of skin-specific drug delivery with a spatio-temporal control has just recently received concerns in dermatology. Inspired by the progress in smart materials and their perspective application in medicine science, development of stimuli responsive drug delivery systems with skin-specificity has become possi...

journal_title：International journal of pharmaceutics

authors： Chen Y,Chen N,Feng X

更新日期：2021-01-05 00:00:00

abstract：:Calcium phosphate nanoparticles present a unique class of non-viral vectors, which can serve as efficient and alternative DNA carriers for targeted delivery of genes. In this study we report the design and synthesis of ultra-low size, highly monodispersed DNA doped calcium phosphate nanoparticles of size around 80 nm ...

journal_title：International journal of pharmaceutics

authors： Roy I,Mitra S,Maitra A,Mozumdar S

更新日期：2003-01-02 00:00:00

abstract：:Multimodal imaging-guided multistage targeted synergistic combination therapy possesses many advantages including increased tumoricidal effect, reduced toxicity, and retarded drug resistance. Herein, we have elaborately developed a core-interlayer-shell structure Fe3O4@mSiO2@lipid-PEG-methotrexatenanoparticle(FMLM), i...

journal_title：International journal of pharmaceutics

authors： Liu G,Ma J,Li Y,Li Q,Tan C,Song H,Cai S,Chen D,Hou Z,Chen Q,Zhu X

更新日期：2017-04-15 00:00:00

abstract：:In the present study, we developed and evaluated an in situ gelling system based on hexanoyl glycol chitosan (H-GCS) for enhanced ocular bioavailability. An aqueous solution of H-GCS exhibited a typical sol-gel transition at 32 °C. The formed H-GCS hydrogel was characterized by rheology and scanning electron microscop...

journal_title：International journal of pharmaceutics

authors： Shi H,Wang Y,Bao Z,Lin D,Liu H,Yu A,Lei L,Li X,Xu X

更新日期：2019-10-30 00:00:00

abstract：:The kinetics of degradation of the new anti-tumor drug, 4-dedimethylamino sancycline (col-3) in aqueous solution at 25oC were investigated by high-pressure liquid chromatography (HPLC) over the pH-range of 2-10. The influences of pH, buffer concentration, light, temperature, and some additives on the degradation rate ...

journal_title：International journal of pharmaceutics

authors： Pinsuwan S,Alvarez-Núñez FA,Tabibi ES,Yalkowsky SH

更新日期：1999-04-20 00:00:00

abstract：:A bilayer tablet, which consisted of telmisartan and amlodipine besylate, was formulated based on a Quality by Design (QbD) approach. The control and response factors were determined based on primary knowledge and the target values of the control tablet (Twynsta®). A D-optimal mixture design was used to obtain the opt...

journal_title：International journal of pharmaceutics

authors： Lee AR,Kwon SY,Choi DH,Park ES

更新日期：2017-12-20 00:00:00

abstract：:Although parabens have several features of ideal preservatives, different studies have shown that they may affect human health due to their estrogenic activity. Therefore, various strategies have been applied to reduce their skin penetration. However, the effect of paraben combinations on transdermal permeation has no...

journal_title：International journal of pharmaceutics

authors： Caon T,Costa AC,de Oliveira MA,Micke GA,Simões CM

更新日期：2010-05-31 00:00:00

abstract：:This paper describes the effect on Sun Protection Factor (SPF) of the combination of inorganic and organic filters in sunscreen products as determined by an in vitro method. O/W emulsions containing inorganic filters, such as titanium dioxide and zinc oxide, combined with 18 EU-authorized UV-B organic filters were tes...

journal_title：International journal of pharmaceutics

authors： El-Boury S,Couteau C,Boulande L,Paparis E,Coiffard LJ

更新日期：2007-08-01 00:00:00

abstract：:To evaluate the intestinal permeability of poorly water-soluble compounds, it is of importance to completely dissolve them in a medium and to avoid precipitation during experiments. This study was undertaken to find an agent possessing a high-solubilizing capacity and exhibiting minimal modulating impact on membrane i...

journal_title：International journal of pharmaceutics

authors： Oda M,Saitoh H,Kobayashi M,Aungst BJ

更新日期：2004-08-06 00:00:00

abstract：:Cell replacement therapy is a widely discussed novel concept of medical treatment. The increased knowledge in the stem cell field, particularly pluripotent stem cells, potentially provides powerful tools for this therapeutic concept. A large number of disease characterized by the loss of functional cells are potential...

journal_title：International journal of pharmaceutics

authors： Preynat-Seauve O,Burkhard PR,Villard J,Zingg W,Ginovart N,Feki A,Dubois-Dauphin M,Hurst SA,Mauron A,Jaconi M,Krause KH

更新日期：2009-11-03 00:00:00

abstract：:Spray dried dispersions (SDDs) of glipizide, a BCS Class II model drug, were prepared using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) and copovidone S-630 as carriers. The SDDs appeared as a single amorphous phase with up to 60% drug loading level as revealed by X-ray powder diffractio...

journal_title：International journal of pharmaceutics

authors： Lu Z,Yang Y,Covington RA,Bi YV,Dürig T,Ilies MA,Fassihi R

更新日期：2016-09-25 00:00:00

abstract：:Chitosan microparticles as carriers for GRA-1 protein vaccine were prepared and characterized with respect to loading efficiency and GRA-1 stability after short-term storage. Chitosan nanoparticles as carriers for GRA-1 pDNA vaccine were prepared and characterized with respect to size, zeta potential, and protection o...

journal_title：International journal of pharmaceutics

authors： Bivas-Benita M,Laloup M,Versteyhe S,Dewit J,De Braekeleer J,Jongert E,Borchard G

更新日期：2003-11-06 00:00:00

abstract：:Design of a pH sensitive alginate-guar gum hydrogel crosslinked with glutaraldehyde was done for the controlled delivery of protein drugs. Alginate is a non-toxic polysaccharide with favorable pH sensitive properties for intestinal delivery of protein drugs. Drug leaching during hydrogel preparation and rapid dissolut...

journal_title：International journal of pharmaceutics

authors： George M,Abraham TE

更新日期：2007-04-20 00:00:00

abstract：:Amorphous lactose will crystallise rapidly if its glass transition temperature is reduced below its storage temperature. This is readily achieved by storing samples at ambient temperature and a relative humidity (RH) of greater than 50%. If the sample is monitored in an isothermal microcalorimeter as it crystallises, ...

journal_title：International journal of pharmaceutics

authors： Dilworth SE,Buckton G,Gaisford S,Ramos R

更新日期：2004-10-13 00:00:00

abstract：:Aptamers, nucleic acid ligands that are specific against their corresponding targets are increasingly employed in a variety of applications including diagnostics and therapeutics. The specificity of the aptamers against their targets is also used as the basis for the formulation of the aptamer-based drug delivery syst...

journal_title：International journal of pharmaceutics

authors： Citartan M,Kaur H,Presela R,Tang TH

更新日期：2019-08-15 00:00:00

abstract：:This study focuses on evaluating the potential of transferring from a batch process to continuous process for manufacturing of the extended release formulation. Metformin hydrochloride (HCl) was used in the model formulation which was intended to contain the high amount of hydrophilic drug. The effects of barrel tempe...

journal_title：International journal of pharmaceutics

authors： Kim SH,Hwang KM,Cho CH,Nguyen TT,Seok SH,Hwang KM,Kim JY,Park CW,Rhee YS,Park ES

更新日期：2017-08-30 00:00:00

abstract：:The aim of this work was to prepare and characterize inclusion complexes between a synthetic curcumin analog (dibenzalacetone, DBA) and beta-cyclodextrin (β-CD); and to evaluate their in vitro antileishmanial activity. DBA was synthetized and characterized by spectroscopic methods and the inclusion complexes were obta...

journal_title：International journal of pharmaceutics

authors： Pinto LMA,Adeoye O,Thomasi SS,Francisco AP,Carvalheiro MC,Cabral-Marques H

更新日期：2020-08-25 00:00:00

abstract：:The objectives of this study were to describe the pharmacokinetics and tissue distribution of superparamagnetic iron oxide nanoparticle (SPIO) stabilized with alginate (SPIO-alginate), and investigate its potential in detecting liver cancers as a newly developed magnetic resonance (MR) contrast agent. Pharmacokinetics...

journal_title：International journal of pharmaceutics

authors： Ma HL,Xu YF,Qi XR,Maitani Y,Nagai T

更新日期：2008-04-16 00:00:00

abstract：:In this work calcium stearate (CaSt) multi-particulates loaded with codeine phosphate (COP) were developed in an attempt to provide extended release (ER) combined with alcohol dose dumping (ADD) resistance. The pellets were prepared via wet/extrusion spheronization and ER characteristics were obtained after fluid bed ...

journal_title：International journal of pharmaceutics

authors： Schrank S,Jedinger N,Wu S,Piller M,Roblegg E

更新日期：2016-07-25 00:00:00

abstract：:The short half-life and bitter taste of carbinoxamine maleate2 (CAM) lead to poor compliance by pediatric patients who are being treated for allergic rhinitis. To address these issues, carbinoxamine-resin complexes3 (CRCs) were prepared by ion exchange and then coated with Kollicoat SR 30D. The resultant microencapsul...

journal_title：International journal of pharmaceutics

authors： Deng Y,Wang T,Li J,Sun W,He H,Gou J,Wang Y,Yin T,Zhang Y,Tang X

更新日期：2020-10-15 00:00:00

abstract：:Molar refraction as well as refractive index has many uses. Beyond confirming the identity and purity of a compound, determination of molecular structure and molecular weight, molar refraction is also used in other estimation schemes, such as in critical properties, surface tension, solubility parameter, molecular pol...

journal_title：International journal of pharmaceutics

authors： Dredán J,Zelkó R,Dávid AZ,Antal I

更新日期：2006-03-09 00:00:00

abstract：:Formulations of ultra-deformable liposomes containing bleomycin (Bleosome) have previously been described and proposed for topical treatment of skin cancer [Lau, K.G., Chopra, S., Maitani, Y., 2003. Entrapment of bleomycin in ultra-deformable liposomes. S. T. P. Pharm. Sci. 13, 237-239]. In this study, the stability o...

journal_title：International journal of pharmaceutics

authors： Lau KG,Hattori Y,Chopra S,O'Toole EA,Storey A,Nagai T,Maitani Y

更新日期：2005-08-26 00:00:00