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Thermosensitive glycol chitosan-based hydrogel as a topical ocular drug delivery system for enhanced ocular bioavailability.

Abstract：

:In the present study, we developed and evaluated an in situ gelling system based on hexanoyl glycol chitosan (H-GCS) for enhanced ocular bioavailability. An aqueous solution of H-GCS exhibited a typical sol-gel transition at 32 °C. The formed H-GCS hydrogel was characterized by rheology and scanning electron microscopy (SEM). H-GCS had minimal in vitro cytotoxicity against L-929 and HCEC cells over a concentration range of 0-0.8 mg/mL. Additionally, the H-GCS hydrogel exhibited good ocular tolerance and biocompatibility after a single instillation. Moreover, H-GCS hydrogel significantly prolonged the precorneal retention of fluorescein sodium compared with its aqueous solution. An in vivo pharmacokinetic study demonstrated that the levofloxacin-loaded H-GCS hydrogel could provide a significantly higher Cmax and AUC0-12h compared with the levofloxacin aqueous solution, thus increasing ocular bioavailability. Overall, the proposed H-GCS hydrogel acts as an in situ gelling system that might represent a promising vehicle for topical ocular drug delivery.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Shi H,Wang Y,Bao Z,Lin D,Liu H,Yu A,Lei L,Li X,Xu X

doi

10.1016/j.ijpharm.2019.118688

subject

Has Abstract

pub_date

2019-10-30 00:00:00

pages

118688

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(19)30733-1

journal_volume

570

pub_type

杂志文章

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