Abstract:
:The aims of this study were to examine the phase behavior of itraconazole-phenol mixtures and assess the feasibility of topical formulations of itraconazole using eutectic mixture systems. Itraconazole-phenol eutectic mixtures were characterized using differential scanning calorimetry, Fourier transform infrared spectroscopy, (1)H-nuclear magnetic resonance, and powder X-ray diffractometry. The skin permeation rates of itraconazole-phenol eutectic formulations were determined using Franz diffusion cells fitted with excised hairless mouse skins. Itraconazole can form eutectic compounds with phenol, and the hydrogen-bonding interactions between the carbonyl group in the itraconazole and hydroxyl group in phenol play a major role in itraconazole-phenol eutectic formation. Despite its high molecular weight and hydrophobicity, the drug (i.e., itraconazole) can be permeated through excised hairless mouse skins from itraconazole-phenol eutectic formulations. The findings of this study emphasize the capabilities of the topical application of itraconazole via external preparations.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Park CW,Mansour HM,Oh TO,Kim JY,Ha JM,Lee BJ,Chi SC,Rhee YS,Park ESdoi
10.1016/j.ijpharm.2012.07.054subject
Has Abstractpub_date
2012-10-15 00:00:00pages
652-8issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(12)00775-2journal_volume
436pub_type
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