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Influence of surface charge and inner composition of porous nanoparticles to cross blood-brain barrier in vitro.

Abstract：

:The aim of these studies was to evaluate the binding, uptake and transcytosis of 60 nm porous nanoparticles (NPs) that differed in their surface charge and inner composition on the blood-brain barrier (BBB). They were prepared from maltodextrins derived with or without a cationic ligand. In the cationic NPs an anionic lipid was inserted in their core to give DPPG-NPs. The data showed that at 4 degrees C the three NPs bind in different areas on endothelial cells: cationic NPs were found mainly around the paracellular area, while neutral NPs were mainly on the cell surface and DPPG-NPs binding was found at both paracellular areas and on the surface of the cells. At 37 degrees C neutral and cationic NPs had similar degrees of binding and uptake and were transcytosed. Filipin treatment increased their binding and uptake suggesting that sterols are implied in their efflux. Neutral NPs transcytosis was also inhibited by filipin. This inhibition shows that neutral NPs, like LDL in this model, use the caveolae pathway. Neutral and cationic 60 nm porous NPs are potential candidates for drug delivery to the brain.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Jallouli Y,Paillard A,Chang J,Sevin E,Betbeder D

doi

10.1016/j.ijpharm.2007.06.023

subject

Has Abstract

pub_date

2007-11-01 00:00:00

pages

103-9

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(07)00499-1

journal_volume

344

pub_type

杂志文章

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