Abstract:
:Gravimetric water sorption experiments were performed to study the crystallization behavior of amorphous spray-dried lactose over a wide range of temperature and humidity conditions. Experiments performed at 25 degrees C between 48 and 60% relative humidity (RH) showed that the onset time to crystallization increased dramatically with decreasing humidity. At 55% RH and above, crystallization occurred in a single detectable step, while below a two-step process was observed. Experiments performed at 51% RH between 22 and 32 degrees C indicated the induction time to crystallization onset increased with decreasing temperature. Above 25 degrees C at 51% RH, crystallization occurred in one measurable step, while below crystallization occurred in two steps. The constant RH with varying temperature results were modeled to determine the crystallization mechanism. Above 25 degrees C a mechanism consisting of two competing reaction sequences fit the data with a 0.9997 correlation coefficient. Both reaction sequences have two steps: an auto-catalytic first step is followed by a three-dimensional diffusion controlled water loss step.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Burnett DJ,Thielmann F,Sokoloski T,Brum Jdoi
10.1016/j.ijpharm.2006.01.012keywords:
subject
Has Abstractpub_date
2006-04-26 00:00:00pages
23-8issue
1-2eissn
0378-5173issn
1873-3476pii
S0378-5173(06)00043-3journal_volume
313pub_type
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