当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF PHARMACEUTICS期刊下所有文献 > CombiCap: A novel drug formulation for the basel phenotyping cocktail.

CombiCap: A novel drug formulation for the basel phenotyping cocktail.

Abstract：

:Phenotyping of cytochrome P450 isoenzymes is used for metabolic profiling. Phenotyping cocktails are usually administered as individual marketed products, which are not designed for diagnostic applications. Therefore, a formulation strategy was developed, which can be applied to any phenotyping cocktail. The formulation was validated in vitro and in vivo in human volunteers using caffeine, efavirenz, flurbiprofen, metoprolol, midazolam, and omeprazole (Basel Cocktail). Spray dried di-calcium phosphate particles (Fujicalin) were used as an inert drug carrier for probe drugs. All drugs were successfully loaded into Fujicalin by a solvent evaporation method. Mini-tablets were produced and demonstrated good physical characteristics, expected drug content and immediate release profiles for all drug formulations. Mini-tablets were introduced into a capsule (CombiCap) and used for a pilot study in human volunteers. Plasma samples were collected and analyzed by liquid chromatography and mass spectrometry. Plasma concentration ratios between the parent drugs and the respective metabolites were equivalent for the novel CombiCap formulation and individually dosed Basel Cocktail drugs. We conclude that the CombiCap formulation platform can be easily adopted for different types of phenotyping cocktails due to its scalable and modular design, which allows a simple and convenient combination of variable doses of different probe drugs.

journal_name

Int J Pharm

journal_title

International journal of pharmaceutics

authors

Camblin M,Berger B,Haschke M,Krähenbühl S,Huwyler J,Puchkov M

doi

10.1016/j.ijpharm.2016.08.043

subject

Has Abstract

pub_date

2016-10-15 00:00:00

pages

253-261

issue

1

eissn

0378-5173

issn

1873-3476

pii

S0378-5173(16)30793-1

journal_volume

512

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF PHARMACEUTICS文献大全
  • Preparation, formula optimization and antitumor actions of mannitol coupling camptothecin nanoparticles.

    abstract：:The purpose of this work is to prepare a formulation using mannitol coupling Camptothecin (CPT) nanoparticles (CPT-NPs) to circumvent the difficult solubilization practice based on central composite experimental statistical design. CPT-NPs were prepared with a high-pressure homogenization technique method. The indepen...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.02.019

    authors： Wang Z,Li Q,Zhao X,Sun B,Zhu Q,Gao W,Hua C

    更新日期：2014-04-25 00:00:00

  • Combinatorial MAPLE deposition of antimicrobial orthopedic maps fabricated from chitosan and biomimetic apatite powders.

    abstract：:Chitosan/biomimetic apatite thin films were grown in mild conditions of temperature and pressure by Combinatorial Matrix-Assisted Pulsed Laser Evaporation on Ti, Si or glass substrates. Compositional gradients were obtained by simultaneous laser vaporization of the two distinct material targets. A KrF* excimer (λ=248n...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.07.015

    authors： Visan A,Stan GE,Ristoscu C,Popescu-Pelin G,Sopronyi M,Besleaga C,Luculescu C,Chifiriuc MC,Hussien MD,Marsan O,Kergourlay E,Grossin D,Brouillet F,Mihailescu IN

    更新日期：2016-09-10 00:00:00

  • Characterization, selection, and development of an orally dosed drug polymorph from an enantiotropically related system.

    abstract：:Solid-state characterization methods are used to study a dimorphic pharmaceutical compound and select a form for development. Polymorph screening found that [4-(4-chloro-3-fluorophenyl)-2-[4-(methyloxy)phenyl]-1,3-thiazol-5-yl] acetic acid can crystallize into two non-solvated polymorphs designated Forms 1 and 2. Phys...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2008.08.044

    authors： Katrincic LM,Sun YT,Carlton RA,Diederich AM,Mueller RL,Vogt FG

    更新日期：2009-01-21 00:00:00

  • N-terminal mono-PEGylation of growth hormone antagonist: correlation of PEG size and pharmacodynamic behavior.

    abstract：:Growth hormone antagonist (GHA), an analog of growth hormone (GH), can inhibit GH action and treat acromegaly. However, GHA suffers from a short plasma half-life of 15-20 min that has limited its clinical application. PEGylation, conjugation with polyethylene glycol (PEG), can increase the plasma half-life of GHA. Sin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2013.06.022

    authors： Wu L,Ho SV,Wang W,Gao J,Zhang G,Su Z,Hu T

    更新日期：2013-09-10 00:00:00

  • An industrial perspective on the design and development of medicines for older patients.

    abstract：:An increasing elderly population is leading to a change in the global demographics. This presents a new challenge to society and the pharmaceutical industry. This demographic shift is providing an opportunity for the pharmaceutical industry to meet the specific needs of the changing patient population. One issue that ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2016.03.008

    authors： Page S,Coupe A,Barrett A

    更新日期：2016-10-30 00:00:00

  • Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.

    abstract：:The purpose of this study was to construct isotretinoin-loaded SLN (IT-SLN) formulation with skin targeting for topical delivery of isotretinoin. PRECIROL ATO 5 was selected as the lipid of SLN. Tween 80 and soybean lecithin were used as the surfactants to stabilize SLN. The hot homogenization method was performed to ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.007

    authors： Liu J,Hu W,Chen H,Ni Q,Xu H,Yang X

    更新日期：2007-01-10 00:00:00

  • A therapeutic dose of primaquine can be delivered across excised human skin from simple transdermal patches.

    abstract：:This work investigated the permeation of primaquine across full-thickness excised human skin from two acrylate transdermal adhesives. Primaquine base was formulated with National Starch 387-2516 and 387-2287 to provide aluminium foil-backed 1-cm diameter patches, each loaded with 10 mg drug. Other patches were prepare...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(99)00215-x

    authors： Jeans CW,Heard CM

    更新日期：1999-10-28 00:00:00

  • In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate.

    abstract：:The purpose of this study was to develop Pluronic F127 (PF127) based formulations of timolol maleate (TM) aimed at enhancing its ocular bioavailability. The effect of isotonicity agents and PF127 concentrations on the rheological properties of the prepared formulations was examined. In an attempt to reduce the concent...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00234-x

    authors： El-Kamel AH

    更新日期：2002-07-08 00:00:00

  • Transdermal iontophoretic delivery of terbinafine hydrochloride: quantitation of drug levels in stratum corneum and underlying skin.

    abstract：:The objective of this study was to determine the effect of iontophoresis on the delivery of terbinafine hydrochloride (4%, w/w) into and across hairless rat skin. In vitro skin uptake and permeation studies were performed using Franz diffusion cells. Anodal iontophoresis was applied for 1h at current densities of 0.2,...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2009.12.029

    authors： Sachdeva V,Siddoju S,Yu YY,Kim HD,Friden PM,Banga AK

    更新日期：2010-03-30 00:00:00

  • Detection and characterization of protein aggregates by fluorescence microscopy.

    abstract：:Aggregation may compromise the stability as well as the biological activity of protein drugs. Detection of protein aggregates is needed in the process of protein characterization and during optimization of pharmaceutical formulations. This paper describes a technique, which consists of analysing protein aggregates by ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2006.08.024

    authors： Demeule B,Gurny R,Arvinte T

    更新日期：2007-02-01 00:00:00

  • Nanohybrid biodegradable scaffolds for TGF-β3 release for the chondrogenic differentiation of human mesenchymal stem cells.

    abstract：:An ideal scaffold for bone tissue engineering should have chondroinductive, biodegradable, and biocompatible properties, as well as the ability to absorb and slowly release the biological molecules. In order to develop such a system to support bone tissue regeneration, in the present study, we developed a three-dimens...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119248

    authors： Qasim M,Le NXT,Nguyen TPT,Chae DS,Park SJ,Lee NY

    更新日期：2020-05-15 00:00:00

  • Enhanced oral delivery of alendronate by sucrose fatty acids esters in rats and their absorption-enhancing mechanisms.

    abstract：:Oral delivery is the most fascinating route for interminable drug remedy. However, the intestinal absorption of alendronate (ALN), a bisphosphonate drug after oral administration is very poor. Absorption enhancers, which help to achieve the efficiency-safety balance, are considered one of the most promising agents for...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2016.10.046

    authors： Alama T,Katayama H,Hirai S,Ono S,Kajiyama A,Kusamori K,Katsumi H,Sakane T,Yamamoto A

    更新日期：2016-12-30 00:00:00

  • Distinct transduction modes of arginine-rich cell-penetrating peptides for cargo delivery into tumor cells.

    abstract：:The application of cell-penetrating peptides (CPPs) for delivering various cargo molecules with biological functions into cells has gained much attention in recent years. However, the internalization mechanisms and delivery properties of CPP-cargo remains controversial. In this study, low- and high-molecular-weight ca...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.08.001

    authors： Ma DX,Shi NQ,Qi XR

    更新日期：2011-10-31 00:00:00

  • Effect of cholesterol and temperature on the elastic properties of niosomal membranes.

    abstract：:The mechanical characteristics of non-ionic bilayer membranes composed of sorbitan monostearate, cholesterol and poly-24-oxyethylene cholesteryl were studied by measuring the modulus of surface elasticity (mu), a measure of membrane strength, as a function of cholesterol content and temperature. The modulus of surface...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.05.009

    authors： Nasseri B

    更新日期：2005-08-26 00:00:00

  • Interaction of gatifloxacin with efflux transporters: a possible mechanism for drug resistance.

    abstract：:The purpose of the study is to screen the interactions of fourth generation fluoroquinolone-gatifloxacin with efflux pumps, i.e., P-gp, MRP2 and BCRP. Mechanism of gatifloxacin interaction with efflux transporters may explain its acquired resistance. Such clarification may lead to the development of strategies to over...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2010.05.027

    authors： Kwatra D,Vadlapatla RK,Vadlapudi AD,Pal D,Mitra AK

    更新日期：2010-08-16 00:00:00

  • Preliminary pharmaceutical development of antimalarial-antibiotic cotherapy as a pre-referral paediatric treatment of fever in malaria endemic areas.

    abstract：:Artemether (AM) plus azithromycin (AZ) rectal co-formulations were studied to provide pre-referral treatment for children with severe febrile illnesses in malaria-endemic areas. The target profile required that such product should be cheap, easy to administer by non-medically qualified persons, rapidly effective again...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.04.023

    authors： Gaubert A,Kauss T,Marchivie M,Ba BB,Lembege M,Fawaz F,Boiron JM,Lafarge X,Lindegardh N,Fabre JL,White NJ,Olliaro PL,Millet P,Grislain L,Gaudin K

    更新日期：2014-07-01 00:00:00

  • Lecithin-linker formulations for self-emulsifying delivery of nutraceuticals.

    abstract：:Lecithin-linker microemulsions are formulations produced with soybean lecithin in combination with a highly lipophilic (lipophilic linker) and highly hydrophilic (hydrophilic linkers) surfactant-like additives. In this work, lecithin-linker systems were formulated to produce self-emulsifying delivery systems for β-car...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2014.05.001

    authors： Chu J,Cheng YL,Rao AV,Nouraei M,Zarate-Muñoz S,Acosta EJ

    更新日期：2014-08-25 00:00:00

  • Characterization of strain rate sensitivity in pharmaceutical materials using indentation creep analysis.

    abstract：:Understanding how a material's response to stress changes as the stress is applied at different rates is important in predicting performance of pharmaceutical powders during tablet compression. Widely used methods for determining strain rate sensitivity (SRS) are empirically based and can often provide inconsistent or...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2012.09.006

    authors： Katz JM,Buckner IS

    更新日期：2013-02-14 00:00:00

  • Curcumin nanoparticles containing poloxamer or soluplus tailored by high pressure homogenization using antisolvent crystallization.

    abstract：:Curcumin is a natural active constituent of Curcuma longa from Zingiberaceae family that shows many different pharmacological effects such as anticancer, antioxidant, anti-inflammatory, antimicrobial and antiviral effect. However, its bioavailability is profoundly limited by its poor water solubility. In this study an...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.03.038

    authors： Homayouni A,Amini M,Sohrabi M,Varshosaz J,Nokhodchi A

    更新日期：2019-05-01 00:00:00

  • Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer.

    abstract：:In spite of the high incidence of breast cancer worldwide, there are few strategies for its chemoprevention, and they have limited adherence mainly due to their serious adverse effects. As a new approach for local breast cancer chemoprevention, we developed and optimized microemulsions for topical delivery of celecoxi...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2019.02.011

    authors： Mojeiko G,de Brito M,Salata GC,Lopes LB

    更新日期：2019-04-05 00:00:00

  • Development of machine learning models of β-cyclodextrin and sulfobutylether-β-cyclodextrin complexation free energies.

    abstract：:A new set of 142 experimentally determined complexation constants between sulfobutylether-β-cyclodextrin and diverse organic guest molecules, and 78 observations reported in literature, were used for the development of the QSPR models by the two machine learning regression methods - Cubist and Random Forest. Similar m...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.03.065

    authors： Merzlikine A,Abramov YA,Kowsz SJ,Thomas VH,Mano T

    更新日期：2011-10-14 00:00:00

  • Influence of niacinamide containing formulations on the molecular and biophysical properties of the stratum corneum.

    abstract：:Niacinamide-containing moisturisers are known be efficacious in alleviating dry skin conditions and improving stratum corneum (SC) barrier function. However, the mechanisms of action of niacinamide at the molecular level in the SC are still not well understood. Previously, we have reported the development of novel met...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ijpharm.2012.11.043

    authors： Mohammed D,Crowther JM,Matts PJ,Hadgraft J,Lane ME

    更新日期：2013-01-30 00:00:00

  • Effect of preparation technique on the properties of liposomes encapsulating ketoprofen-cyclodextrin complexes aimed for transdermal delivery.

    abstract：:The combined approach of cyclodextrin complexation and entrapment in liposomes was investigated in order to develop an effective topical formulation of ketoprofen. Equimolar complex of drug and hydroxypropyl-beta-cyclodextrin (HPbetaCyd) was added at different concentrations to the aqueous phase of liposomes consistin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2005.12.047

    authors： Maestrelli F,González-Rodríguez ML,Rabasco AM,Mura P

    更新日期：2006-04-07 00:00:00

  • Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin.

    abstract：:The effects of vehicles and penetration enhancers on the in vitro permeation of tenoxicam from saturated solutions through dorsal hairless mouse skin were investigated. Various types of vehicles, including ester-, alcohol-, and ether-types and their mixtures, were used as vehicles, and then a series of fatty acids and...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/s0378-5173(02)00009-1

    authors： Gwak HS,Chun IK

    更新日期：2002-04-02 00:00:00

  • Approaches to determine the enthalpy of crystallisation, and amorphous content, of lactose from isothermal calorimetric data.

    abstract：:Amorphous lactose will crystallise rapidly if its glass transition temperature is reduced below its storage temperature. This is readily achieved by storing samples at ambient temperature and a relative humidity (RH) of greater than 50%. If the sample is monitored in an isothermal microcalorimeter as it crystallises, ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2004.07.016

    authors： Dilworth SE,Buckton G,Gaisford S,Ramos R

    更新日期：2004-10-13 00:00:00

  • Evaluation of the immunogenicity and in vivo toxicity of the antimicrobial peptide P34.

    abstract：:Immunogenicity and toxicity of antimicrobial peptide P34 were evaluated in vivo. BALB/c mice were inoculated intraperitoneally with peptide P34 alone and associated with Freund's adjuvant. For acute toxicity testing, different concentrations of the peptide P34 (82.5, 165.0, 247.5 and 330.0mg/kg) were orally administer...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.09.020

    authors： Vaucher Rde A,Velho Gewehr Cde C,Correa AP,Sant'Anna V,Ferreira J,Brandelli A

    更新日期：2011-12-12 00:00:00

  • Solid-state compatibility studies using a high-throughput and automated forced degradation system.

    abstract：:As the number of pharmaceutical candidate compounds increases, so does the need for development workflow that is capable of handling more compounds in shorter times. In this paper, the establishment of a high-throughput automated powder compatibility testing system is reported. The integrated robotic system automatica...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2007.12.002

    authors： Wakasawa T,Sano K,Hirakura Y,Toyo'oka T,Kitamura S

    更新日期：2008-05-01 00:00:00

  • Terahertz pulsed imaging as an advanced characterisation tool for film coatings--a review.

    abstract：:Solid dosage forms are the pharmaceutical drug delivery systems of choice for oral drug delivery. These solid dosage forms are often coated to modify the physico-chemical properties of the active pharmaceutical ingredients (APIs), in particular to alter release kinetics. Since the product performance of coated dosage ...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章,评审

    doi：10.1016/j.ijpharm.2013.03.053

    authors： Haaser M,Gordon KC,Strachan CJ,Rades T

    更新日期：2013-12-05 00:00:00

  • Fabrication and in vivo evaluation of ligand appended paclitaxel and artemether loaded lipid nanoparticulate systems for the treatment of NSCLC: A nanoparticle assisted combination oncotherapy.

    abstract：:The aim of present study was to develop folate appended PEGylated solid lipid nanoparticles(SLNs) of paclitaxel(FPS) and artemether(FAS). The SLNs were prepared by employing high pressure homogenization technique. The results of MTT assays revealed better cytotoxicity of FPS when given in combination with FAS on human...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2020.119386

    authors： Khatri H,Chokshi N,Rawal S,Patel BM,Badanthadka M,Patel MM

    更新日期：2020-06-15 00:00:00

  • Facile synthesis of pH sensitive polymer-coated mesoporous silica nanoparticles and their application in drug delivery.

    abstract：:pH-responsive polymer shell chitosan/poly (methacrylic acid) (CS-PMAA) was coated on mesoporous silica nanoparticles (MSN) through the facile in situ polymerization method. The resultant composite microspheres showed a flexible control over shell thickness, surface charges and hydrodynamic size by adjusting the feedin...

    journal_title：International journal of pharmaceutics

    pub_type： 杂志文章

    doi：10.1016/j.ijpharm.2011.10.013

    authors： Tang H,Guo J,Sun Y,Chang B,Ren Q,Yang W

    更新日期：2011-12-15 00:00:00