Abstract:
:pH-responsive polymer shell chitosan/poly (methacrylic acid) (CS-PMAA) was coated on mesoporous silica nanoparticles (MSN) through the facile in situ polymerization method. The resultant composite microspheres showed a flexible control over shell thickness, surface charges and hydrodynamic size by adjusting the feeding amount of MSN and the molar ratio of [-NH(2)]/MAA. The MSN/CS-PMAA composite microspheres were stable in the pH range of 5-8 as well as in the physiological saline (0.15M NaCl). Doxorubicin hydrochloride (DOX) was applied as a model drug to investigate the drug storage and release behavior. The results demonstrated that DOX could be effectively loaded into the composite microspheres. The cumulative release of DOX-loaded composite microspheres was pH dependent and the release rate was much faster at low pH (5.5) than that of pH 7.4. The cytotoxicity test by MTT assay showed that the blank carrier MSN/CS-PMAA microspheres were suitable as drug carriers. The cellular uptake of composite microspheres was investigated by confocal laser scanning microscopy (CLSM), which indicated that MSN/CS-PMAA could deliver the drugs into HeLa cell. The above results imply that the composite microspheres are a promising drug delivery system for cancer therapy.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
Tang H,Guo J,Sun Y,Chang B,Ren Q,Yang Wdoi
10.1016/j.ijpharm.2011.10.013subject
Has Abstractpub_date
2011-12-15 00:00:00pages
388-96issue
2eissn
0378-5173issn
1873-3476pii
S0378-5173(11)00908-2journal_volume
421pub_type
杂志文章abstract::The aim of this study was to compare the expression of organic cation transporters (OCTs) in normal and polyps nasal epithelium. Primary cell cultures of human nasal epithelium (polyps and normal tissues) were compared by investigating the uptake of a fluorescent organic cation, [4-dimethylaminostyryl-N-methylpyridini...
journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章,评审
doi:10.1016/j.ijpharm.2007.04.021
更新日期:2007-07-18 00:00:00
abstract::Current treatment for pelvic organ prolapse (POP) and stress urinary incontinence (SUI) involves transvaginal implantation of surgical mesh, conventionally made of polypropylene (PP). However, it has recently become apparent that the mechanical properties of PP are unsuitable, resulting in serious complications such a...
journal_title:International journal of pharmaceutics
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pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2012.04.074
更新日期:2012-08-20 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2017-09-15 00:00:00
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2006-06-06 00:00:00
abstract:UNLABELLED:To objectively evaluate the performance of new vaginal dosage forms, it is important to determine their time of residence and their distribution. This paper describes the in vivo characteristics of a reference and test product in this situation. METHOD:A randomised cross-over study was performed in the same...
journal_title:International journal of pharmaceutics
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2013-01-30 00:00:00
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pub_type: 杂志文章
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更新日期:2002-10-24 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
doi:10.1016/j.ijpharm.2018.07.061
更新日期:2018-10-05 00:00:00
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pub_type: 杂志文章
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journal_title:International journal of pharmaceutics
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:International journal of pharmaceutics
pub_type: 杂志文章
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pub_type: 杂志文章
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