Abstract:
:Distribution of PLGA-microparticles in porcine skin, after its topical application, was studied in vitro using microparticles containing rhodamine as a fluorescent probe. PLGA-microparticles loaded with rhodamine were prepared using a solvent evaporation technique. Skin distribution of fluorescent microparticles was performed, by horizontal and vertical slicing of frozen skin. Fluorescence photomicrographs revealed that PLGA-microparticles could penetrate through the stratum corneum and reach the epidermis. However, permeation experiments showed that these microparticles were not able to reach the receptor compartment of the diffusion cells, even in a period of 24 h. The carriers described in this work could be used as vehicles for topical drug delivery, in order to obtain a sustained drug release into the skin, improving therapy by reduction of time intervals between doses.
journal_name
Int J Pharmjournal_title
International journal of pharmaceuticsauthors
de Jalón EG,Blanco-Príeto MJ,Ygartua P,Santoyo Sdoi
10.1016/s0378-5173(01)00811-0keywords:
subject
Has Abstractpub_date
2001-09-11 00:00:00pages
181-4issue
1-2eissn
0378-5173issn
1873-3476pii
S0378517301008110journal_volume
226pub_type
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