PLGA microparticles: possible vehicles for topical drug delivery.

Abstract:

:Distribution of PLGA-microparticles in porcine skin, after its topical application, was studied in vitro using microparticles containing rhodamine as a fluorescent probe. PLGA-microparticles loaded with rhodamine were prepared using a solvent evaporation technique. Skin distribution of fluorescent microparticles was performed, by horizontal and vertical slicing of frozen skin. Fluorescence photomicrographs revealed that PLGA-microparticles could penetrate through the stratum corneum and reach the epidermis. However, permeation experiments showed that these microparticles were not able to reach the receptor compartment of the diffusion cells, even in a period of 24 h. The carriers described in this work could be used as vehicles for topical drug delivery, in order to obtain a sustained drug release into the skin, improving therapy by reduction of time intervals between doses.

journal_name

Int J Pharm

authors

de Jalón EG,Blanco-Príeto MJ,Ygartua P,Santoyo S

doi

10.1016/s0378-5173(01)00811-0

keywords:

subject

Has Abstract

pub_date

2001-09-11 00:00:00

pages

181-4

issue

1-2

eissn

0378-5173

issn

1873-3476

pii

S0378517301008110

journal_volume

226

pub_type

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